Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Edward M Behrens"'
Autor:
Kapish Gupta, Jimmy P Xu, Tamir Diamond, Iris E M de Jong, Andrew Glass, Jessica Llewellyn, Neil D Theise, Orith Waisbourd-Zinman, Jeffrey D Winkler, Edward M Behrens, Clementina Mesaros, Rebecca G Wells
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301824 (2024)
Biliary atresia is a neonatal disease characterized by damage, inflammation, and fibrosis of the liver and bile ducts and by abnormal bile metabolism. It likely results from a prenatal environmental exposure that spares the mother and affects the fet
Externí odkaz:
https://doaj.org/article/74507efcbeca4a1daf62e83fff6e33fb
Autor:
Catherine A Chapin, Thomas M Burn, Tamir Diamond, Kathleen M Loomes, Estella M Alonso, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286394 (2023)
A distinct phenotype of pediatric acute liver failure (PALF) has been identified, labeled activated T-cell hepatitis. These patients, previously included within the indeterminate group, have evidence of systemic immune activation and liver biopsy spe
Externí odkaz:
https://doaj.org/article/9d4b7210c09a457e93765223814102db
Autor:
Catherine A Chapin, Sarah A Taylor, Padmini Malladi, Katie Neighbors, Hector Melin‐Aldana, Portia A Kreiger, Nina Bowsher, Matthew J Schipma, Kathleen M Loomes, Edward M Behrens, Estella M Alonso
Publikováno v:
Hepatology Communications, Vol 5, Iss 8, Pp 1373-1384 (2021)
Many patients with indeterminate pediatric acute liver failure (PALF) have evidence of T‐cell driven immune injury; however, the precise inflammatory pathways are not well defined. We have characterized the hepatic cytokine and transcriptional sign
Externí odkaz:
https://doaj.org/article/3907a2ec2a3144ef8b11941980ffb8a2
Autor:
Tamir Diamond, Thomas N Burn, Mailyn A Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A Kreiger, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269553 (2022)
Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known t
Externí odkaz:
https://doaj.org/article/0fcb53d025e74ae28392b294f706d544
Autor:
Chhanda Biswas, Sheila Rao, Katharine Slade, David Hyman, Devin Dersh, Adriana R Mantegazza, Philip W Zoltick, Michael S Marks, Yair Argon, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200913 (2018)
Toll like receptors (TLRs) share a conserved structure comprising the N-terminal ectodomain, a transmembrane segment and a C-terminal cytoplasmic Toll/IL-1 receptor (TIR) domain. Proper assembly of the TIR domain is crucial for signal transduction; h
Externí odkaz:
https://doaj.org/article/5066fcd817d84380a96d6b72376484d7
Autor:
Mobin A Karimi, Eric Lee, Michael H Bachmann, Ana Maria Salicioni, Edward M Behrens, Taku Kambayashi, Cynthia L Baldwin
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89357 (2014)
The chromium-release assay developed in 1968 is still the most commonly used method to measure cytotoxicity by T cells and by natural killer cells. Target cells are loaded in vitro with radioactive chromium and lysis is determined by measuring chromi
Externí odkaz:
https://doaj.org/article/f454915f48d64953b6280e0c5bec48b3
Autor:
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2
Externí odkaz:
https://doaj.org/article/a888480056e0487995e0516acf1b06ce
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 18, Iss 1, Pp 1-5 (2020)
Abstract Background Severe vitamin C deficiency, or scurvy, encompasses a syndrome of multisystem abnormalities due to defective collagen synthesis and antioxidative functions. Among the more common presentations is a combination of oral or subcutane
Externí odkaz:
https://doaj.org/article/7985d06998554569a7435c90f72b2f06
Autor:
Julia E. Rood, Ayman Rezk, Jennifer Pogoriler, Laura S. Finn, Jon M. Burnham, Maureen B. Josephson, Amit Bar-Or, Edward M. Behrens, Scott W. Canna
Publikováno v:
Journal of Clinical Immunology. 43:101-108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9752c1dd9b05be1ea0750154ca0f3e49
https://doi.org/10.1007/s10875-022-01353-y
https://doi.org/10.1007/s10875-022-01353-y
Autor:
Laura A, Adang, Francesco, Gavazzi, Russell, D'Aiello, David, Isaacs, Nowa, Bronner, Zehra Serap, Arici, Zaida, Flores, Amanda, Jan, Carly, Scher, Omar, Sherbini, Edward M, Behrens, Raphaela, Goldbach-Mansky, Timothy S, Olson, Michele P, Lambert, Kathleen E, Sullivan, David T, Teachey, Char, Witmer, Adeline, Vanderver, Justine, Shults
Publikováno v:
Molecular Genetics and Metabolism. 136:324-329
Because of the broad clinical spectrum, heritable autoinflammatory diseases present a management and therapeutic challenge. The most common genetic interferonopathy, Aicardi Goutières Syndrome (AGS), is associated with early onset neurologic disabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1495f2fa9b47d0a0bd410818f06d89cf
https://doi.org/10.1016/j.ymgme.2022.06.003
https://doi.org/10.1016/j.ymgme.2022.06.003