Zobrazeno 1 - 10
of 850
pro vyhledávání: '"Edward M, Brown"'
Autor:
Polina Yarova, Donald T. Ward, Dolores Shoback, Daniela Riccardi, Katie Leach, Fadil Hannan, Arthur Conigrave, Wenhan Chang, Edward M. Brown, Hans Bräuner-Osborne, Daniel Bikle
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
This set contains class C 'orphan' G protein coupled receptors where the endogenous ligand(s) is not known.
Autor:
Polina Yarova, Daniel D. Bikle, Donald T. Ward, Edward M. Brown, Dolores M. Shoback, Fadil Hannan, Hans Bräuner-Osborne, Daniela Riccardi, Arthur D. Conigrave, Katie Leach, Wenhan Chang
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and
Autor:
Chen Zhang, Nagaraju Mulpuri, Fadil M Hannan, M Andrew Nesbit, Rajesh V Thakker, Donald Hamelberg, Edward M Brown, Jenny J Yang
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113622 (2014)
The Ca(2+)-sensing receptor (CaSR) regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)]o) and amino acids. Mutations at the hinge region of the N-terminal Venus flytrap domain (VFTD) produce either receptor
Externí odkaz:
https://doaj.org/article/4d37cc14efa74f3ba3cd8251071ff027
Autor:
Conall M O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A Catharina Brockhaus, Marcus E Kleber, Anubha Mahajan, Florian D Ernst, Vilmundur Gudnason, Lenore J Launer, Aurelien Mace, Eric Boerwinckle, Dan E Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S Siscovick, Bruce M Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M Brown, Karol Estrada, Jingzhong Ding, Tamara B Harris, Stefania Bandinelli, Dena Hernandez, Andrew B Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M Starr, John C Chambers, Bernhard O Boehm, Bernhard R Winkelmann, Jie Huang, Federico Murgia, Sarah H Wild, Harry Campbell, Andrew P Morris, Oscar H Franco, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So-Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, SUNLIGHT Consortium, GEFOS Consortium, Patricia B Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D Spector, Albert V Smith, Igor Rudan, James F Wilson, Ozren Polasek, Ian J Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S Kooner, Jacqueline C M Witteman, Matthias Nauck, W H Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S Fox, Murielle Bochud
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003796 (2013)
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis
Externí odkaz:
https://doaj.org/article/9cfd19b7bfd44ee7bca72436fdaf0f47
Autor:
Hans Bräuner-Osborne, Edward M. Brown, Daniel D. Bikle, Fadil Hannan, Wenhan Chang, Donald T. Ward, Arthur D. Conigrave, Dolores M. Shoback, Polina Yarova, Daniela Riccardi, Katie Leach
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2020
The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [46] and subsequently updated [76]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:550-556
Context\ud While therapy with immune checkpoint inhibitors such as nivolumab have substantially improved survival in several types of cancer, increased attention has been given to adverse immune events associated with their use, including the develop
Autor:
Daniel D. Bikle, Hans Bräuner-Osborne, Arthur D. Conigrave, Edward M. Brown, Dolores M. Shoback
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
This set contains class C 'orphan' G protein coupled receptors where the endogenous ligand(s) is not known.
Autor:
Katie Leach, Donald T. Ward, Arthur D. Conigrave, Polina Yarova, Daniel D. Bikle, Fadil Hannan, Daniela Riccardi, Dolores M. Shoback, Edward M. Brown, Hans Bräuner-Osborne, Wenhan Chang
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [44]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino
Autor:
Michael T. Collins, John P. Bilezikian, Peter L. Lakatos, Edward M. Brown, Anatoly F. Romanischen, Michael Mannstadt, Bart L. Clarke, Rajesh V. Thakker, Michael A. Levine, Harald Jüppner
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 101:2284-2299
Hypoparathyroidism is a disorder characterized by hypocalcemia due to insufficient secretion of PTH. Pseudohypoparathyroidism is a less common disorder due to target organ resistance to PTH. This report summarizes the results of the findings and reco