Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Edward L. LaGory"'
Autor:
Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon, Amato J. Giaccia
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways
Externí odkaz:
https://doaj.org/article/31c54fc7899d4d009ae61cd9a6805ec7
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Xingqi Chen, Ulrike M. Litzenburger, Yuning Wei, Alicia N. Schep, Edward L. LaGory, Hani Choudhry, Amato J. Giaccia, William J. Greenleaf, Howard Y. Chang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Cellular heterogeneity in cancer is complex and difficult to study. Here, the authors introduce Protein-indexed Assay of Transposase Accessible Chromatin (Pi-ATAC), which combines single cell chromatin and proteomic profiling to provide deep insight
Externí odkaz:
https://doaj.org/article/78bb993491fb4b9faed443f446fb2949
Autor:
Edward L. LaGory, Colleen Wu, Cullen M. Taniguchi, Chien-Kuang Cornelia Ding, Jen-Tsan Chi, Rie von Eyben, David A. Scott, Adam D. Richardson, Amato J. Giaccia
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 116-127 (2015)
Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabo
Externí odkaz:
https://doaj.org/article/c95910daf90d42c6b60482a36536d678
Autor:
Dadi Jiang, Edward L. LaGory, Daniela Kenzelmann Brož, Kathryn T. Bieging, Colleen A. Brady, Nichole Link, John M. Abrams, Amato J. Giaccia, Laura D. Attardi
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1096-1109 (2015)
The p53 tumor suppressor plays a key role in maintaining cellular integrity. In response to diverse stress signals, p53 can trigger apoptosis to eliminate damaged cells or cell-cycle arrest to enable cells to cope with stress and survive. However, th
Externí odkaz:
https://doaj.org/article/83a777ee595942b28dbf89a26e4abbef
Autor:
Edward L. LaGory, Colin Holbrook, Sang-Ging Ong, Chris Denning, Andrew H. Chang, John W. Day, Martin K. Childers, Alexandre J.S. Ribeiro, Honghui Wang, Alex C.Y. Chang, Gaspard Pardon, Joseph C. Wu, Kassie Koleckar, Sara Ancel, Helen M. Blau, David L. Mack, John Ramunas, Amato J. Giaccia, Asuka Eguchi, Haodi Wu, Beth L. Pruitt
Publikováno v:
Stem Cell Reports
Stem cell reports, vol 16, iss 9
Stem cell reports, vol 16, iss 9
Summary Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected proliferation-in
Autor:
Takamasa Kudo, Michael L. Zhao, Kyle Kovary, Edward L. LaGory, Markus W. Covert, Mary N. Teruel
Hypoxia-induced upregulation of HIF1α triggers adipose tissue dysfunction and insulin resistance in obese patients. HIF1α closely interacts with PPARγ, the master regulator of adipocyte differentiation and lipid accumulation, but there are conflic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe99a9b386a16d4650e6dfd3755433d
https://doi.org/10.1101/2022.05.17.492374
https://doi.org/10.1101/2022.05.17.492374
Autor:
Zhen Jiang, Selma Z. Elsarrag, Qiming Duan, Edward L. LaGory, Zhe Wang, Michael Alexanian, Sarah McMahon, Ingrid C. Rulifson, Sarah Winchester, Yi Wang, Christian Vaisse, Jonathan D. Brown, Mattia Quattrocelli, Charles Y. Lin, Saptarsi M. Haldar
Publikováno v:
Science Advances. 8
Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma c
Autor:
Dhanir Tailor, Angel Resendez, Alisha M. Birk, Vineet Kumar, George W. Sledge, Edward L. LaGory, Tanya Stoyanova, Rana P. Singh, Ali Ghoochani, Jiangbin Ye, Amato J. Giaccia, Arpit Dheeraj, Dhanya Nambiar, Catherine C. Going, Sanjay V. Malhotra, Quynh-Thu Le, Yang Li, Sharon J. Pitteri
Publikováno v:
British Journal of Cancer
Background To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions
Autor:
Yun Sheng Chen, Jianghong Rao, Weiping Zhu, Arvin M. Gouw, Jinghang Xie, Qihua Zhu, Zhi Yuan Wang, Leeann Hu, Liyang Cui, Elena A. Goun, Yao Tang, Ji Qi, Amato J. Giaccia, Zhou Gao, Dean W. Felsher, Shenghao Guo, Anne Le, Min Chen, Mingxi Fang, Kerriann M. Casey, Arkadiy A. Bazhin, Sanjiv S. Gambhir, Cissy Zhang, Nabeel Attarwala, Edward L. LaGory, Mark D. Pegram
Publikováno v:
Nature Biotechnology. 39:357-367
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are to