Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Edward L. Ezell"'
Autor:
Jianbo Wu, Derek A. Leas, Yuxiang Dong, Xiaofang Wang, Edward L. Ezell, Douglas E. Stack, Jonathan L. Vennerstrom
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11362-11367 (2018)
Externí odkaz:
https://doaj.org/article/16b4b3e459e34c02900c2840a6baa13b
Autor:
Derek A. Leas, Jianbo Wu, Edward L. Ezell, Jered C. Garrison, Jonathan L. Vennerstrom, Yuxiang Dong
Publikováno v:
ACS Omega, Vol 3, Iss 1, Pp 781-787 (2018)
Externí odkaz:
https://doaj.org/article/6dec1e77f9704f7f9eb8ee9b92ec6340
Autor:
Huihua Xing, Alison Rodger, Jeffrey Comer, Agustín S. Picco, Cristián Huck-Iriart, Edward L. Ezell, Martin Conda-Sheridan
Publikováno v:
ACS applied bio materials. 5(10)
Hydrogen bonding plays a critical role in the self-assembly of peptide amphiphiles (PAs). Herein, we studied the effect of replacing the amide linkage between the peptide and lipid portions of the PA with a urea group, which possesses an additional h
Autor:
Jayapal Reddy Mallareddy, Edward L. Ezell, Jacob I. Contreras, Smitha Kizhake, Yogesh A. Sonawane, Sandeep Rana, John Victor Napoleon, Christabelle Rajesh, Prakash Radhakrishnan, Sarbjit Singh, Satish Sagar, Amarnath Natarajan, Jered C. Garrison
Publikováno v:
Eur J Med Chem
Genetic models validated Inhibitor of nuclear factor (NF) kappa B kinase beta (IKKβ) as a therapeutic target for KRAS mutation associated pancreatic cancer. Phosphorylation of the activation loop serine residue (S(177), S(181)) IKKβ is a key event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0179ffb6b1a28f61169bb40baf72101f
https://europepmc.org/articles/PMC8373685/
https://europepmc.org/articles/PMC8373685/
Autor:
Edward L. Ezell, Jonathan L. Vennerstrom, Derek A. Leas, Jianbo Wu, Jered C. Garrison, Yuxiang Dong
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 1, Pp 781-787 (2018)
ACS Omega, Vol 3, Iss 1, Pp 781-787 (2018)
We describe a new 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU)-mediated coupling reaction to produce 2-imino benzo[e]-1,3-oxazin-4-ones from salicylic acids and anilines. Mechanistic studies su
Autor:
Xiaodong Cheng, Yogesh A. Sonawane, Edward L. Ezell, Muhammad Zahid, Jered C Garrison, Yingmin Zhu, Amarnath Natarajan
Publikováno v:
ACS Medicinal Chemistry Letters
EPAC proteins are therapeutic targets for the potential treatment of cardiac hypertrophy and cancer metastasis. Several laboratories use a tetrahydroquinoline analog, CE3F4, to dissect the role of EPAC1 in various disease states. Here, we report SAR
Autor:
Hannah M. King, Edward L. Ezell, Smitha Kizhake, Muhammad Zahid, Sydney P. Kubica, Michael J. Naldrett, Jayapal Reddy Mallareddy, Amarnath Natarajan, Henry C.-H. Law, Sophie Alvarez, Nicholas T. Woods, Sandeep Rana
Publikováno v:
Bioorg Med Chem Lett
Cyclin-dependent kinase 9 (CDK9) is a member of the cyclin-dependent kinase (CDK) family which is involved in transcriptional regulation of several genes, including the oncogene Myc, and is a validated target for pancreatic cancer. Here we report the
Autor:
Edward L. Ezell, Jered C. Garrison, Xiaofang Wang, Yuxiang Dong, James P. Hagen, Jonathan L. Vennerstrom, James K. Wood
Publikováno v:
Tetrahedron. 73:2972-2976
A number of new polybrominated adamantanes were formed by rearrangements and bromination of 2,2,6,6-tetrabromoadamantane under Friedel-Crafts conditions. Protoadamantane-4,10-dione, 10-acetoxyprotoadamantan-4-one, 1,2,6-triacetoxyadamantane and 5,6-d
Autor:
Xiaofang Wang, Douglas E. Stack, Yuxiang Dong, Edward L. Ezell, Derek A. Leas, Jianbo Wu, Jonathan L. Vennerstrom
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 9, Pp 11362-11367 (2018)
ACS Omega, Vol 3, Iss 9, Pp 11362-11367 (2018)
2-Azaadamantan-6-one and its Boc and ethylene ketal derivatives were synthesized from 9-oxo endo-bicyclo[3.3.1]non-6-ene-3-carboxylic acid. Similarly, the Cbz, Boc, and ethylene ketal derivatives of 2-azaadamantan-4-one were synthesized from endo-bic
Autor:
Neka A. Simms, Yuxiang Dong, Haizhen A. Zhong, Wang Wang, Jonathan L. Vennerstrom, Michael G. Brattain, Dima A. Sabbah, Edward L. Ezell
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:7175-7183
This work describes our efforts to optimize the lead PI3Kα inhibitor N-benzyl 4-hydroxy-2-quinolone-3-carboxamide using structure-based design and molecular docking. We identified a series of N-phenyl 4-hydroxy-2-quinolone-3-carboxamides as selectiv