Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Edward L. Bolt"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/4f4f8762a53e435fad4176983727f957
Autor:
Liu He, Rebecca Lever, Andrew Cubbon, Muhammad Tehseen, Tabitha Jenkins, Alice O Nottingham, Anya Horton, Hannah Betts, Martin Fisher, Samir M Hamdan, Panos Soultanas, Edward L Bolt
Publikováno v:
Nucleic Acids Research. 51:1740-1749
DNA strand breaks are repaired by DNA synthesis from an exposed DNA end paired with a homologous DNA template. DNA polymerase delta (Pol δ) catalyses DNA synthesis in multiple eukaryotic DNA break repair pathways but triggers genome instability unle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd33cf03a1543691511a3ee856e40cb4
https://doi.org/10.1093/nar/gkad032
https://doi.org/10.1093/nar/gkad032
Autor:
Liu He, Rebecca Lever, Andrew Cubbon, Muhammad Tehseen, Tabitha Jenkins, Alice O. Nottingham, Anya Horton, Hannah Betts, Martin Fisher, Samir M. Hamdan, Panos Soultanas, Edward L. Bolt
DNA strand breaks can be repaired by base-pairing with unbroken homologous DNA, forming a template for new DNA synthesis that patches over the break site. In eukaryotes multiple DNA break repair pathways utilize DNA polymerase δ (Pol δ) to synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::724c651d95ce5903d246d676163f812d
https://doi.org/10.1101/2022.10.02.510506
https://doi.org/10.1101/2022.10.02.510506
Publikováno v:
Biochemical Journal
The DNA helicase Large helicase-related (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair but in a context that is not known. Our data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c000b6f1313302ea52742cca938a5e
http://europepmc.org/articles/PMC7437997
http://europepmc.org/articles/PMC7437997
Publikováno v:
eLife, Vol 4 (2015)
The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements. The fundamental basis of the system is the ability to capture small pieces of foreign DNA for incorporation into the genome at the CRIS
Externí odkaz:
https://doaj.org/article/b4516b779c584d51bd450c2b733bcee2
Autor:
Tabitha Jenkins, Sarah J. Northall, Rebecca Lever, Panos Soultanas, Christopher D.O. Cooper, Andrew Cubbon, Denis Ptchelkine, Hannah Betts, Vincenzo Taresco, Peter J. McHugh, Edward L. Bolt
Publikováno v:
NAR Cancer
Genome instability is a characteristic enabling factor for carcinogenesis. HelQ helicase is a component of human DNA maintenance systems that prevent or reverse genome instability arising during DNA replication. Here, we provide details of the molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a302c643896100694713f42ec0efef4
https://doi.org/10.1093/narcan/zcaa043
https://doi.org/10.1093/narcan/zcaa043
Autor:
Zoe Jelić Matošević, Branimir Bertoša, Liu He, Marija Matković, Dora Markulin, Ivana Ivančić-Baće, Damjan Mitić, Edward L. Bolt, Tom Killelea
Publikováno v:
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2848, p 2848 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2848, p 2848 (2021)
Cas3 is a ssDNA-targeting nuclease-helicase essential for class 1 prokaryotic CRISPR immunity systems, which has been utilized for genome editing in human cells. Cas3-DNA crystal structures show that ssDNA follows a pathway from helicase domains into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0420405703fc0094d74d6c2555d1927f
http://fulir.irb.hr/6905/
http://fulir.irb.hr/6905/
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61442 (2013)
Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of
Externí odkaz:
https://doaj.org/article/bd4901aa710d4234a1cc6185ab57c939
Publikováno v:
Genes
Genes, Vol 11, Iss 458, p 458 (2020)
Genes, Vol 11, Iss 458, p 458 (2020)
Phenotypic complementation of gene knock-outs is an essential step in establishing function. Here we describe a simple strategy for ‘gold standard’ complementation in which the mutant allele is replaced in situ with a wild type (WT) allele in a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8398a9f8bb484f12c4f29f3c57707c4c
https://doi.org/10.20944/preprints202003.0321.v1
https://doi.org/10.20944/preprints202003.0321.v1
Publikováno v:
Genes
Genes, Vol 11, Iss 2, p 208 (2020)
Genes, Vol 11, Iss 2, p 208 (2020)
Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f376b1264ecfd044ecdf5f4295cca410
https://doi.org/10.3390/genes11020208
https://doi.org/10.3390/genes11020208