Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Edward L Briggs"'
Autor:
Edward L. Briggs
Publikováno v:
Organic Syntheses. 100:186-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e54ef16cf2fec96b935f8a6a604e31
https://doi.org/10.15227/orgsyn.0100.0186
https://doi.org/10.15227/orgsyn.0100.0186
Autor:
Juan J. Rojas, Rosemary A. Croft, Alistair J. Sterling, Edward L. Briggs, Daniele Antermite, Daniel C. Schmitt, Luka Blagojevic, Peter Haycock, Andrew J. P. White, Fernanda Duarte, Chulho Choi, James J. Mousseau, James A. Bull
Publikováno v:
Nature Chemistry. 14:160-169
Bioisosteres provide valuable design elements for medicinal chemists to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisosteres for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb10e763271769c5461744accae7ca1
https://doi.org/10.1038/s41557-021-00856-2
https://doi.org/10.1038/s41557-021-00856-2
Autor:
Ulrich Lücking, Andrew J. P. White, Edward L. Briggs, Fahima I M Idiris, James A. Bull, Stephanie Greed
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for additional directional interactions. Here, we present the first modular enantioselective synthesis of sulfonimidamides, including the first stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884b277664c8dc6424ffb370b85287ac
https://doi.org/10.1002/chem.202002265
https://doi.org/10.1002/chem.202002265
Autor:
Bruno Linclau, Jean-Baptiste Vendeville, Clement Q. Fontenelle, Robert Szpera, Mark E. Light, Ramakrishna Kuppala, Edward L Briggs, David E Wheatley, Neil J. Wells
Protein-carbohydrate interactions are implicated in many biochemical/biological processes that are fundamental to life and to human health. Fluorinated carbohydrate analogues play an important role in the study of these interactions and find applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7084be9f42955cdf4ef449719b539715
https://eprints.soton.ac.uk/450092/
https://eprints.soton.ac.uk/450092/
Autor:
David E, Wheatley, Clement Q, Fontenelle, Ramakrishna, Kuppala, Robert, Szpera, Edward L, Briggs, Jean-Baptiste, Vendeville, Neil J, Wells, Mark E, Light, Bruno, Linclau
Publikováno v:
The Journal of organic chemistry. 86(11)
Protein-carbohydrate interactions are implicated in many biochemical/biological processes that are fundamental to life and to human health. Fluorinated carbohydrate analogues play an important role in the study of these interactions and find applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de605cea69bd18ea52ed43c7397e7b94
https://pubmed.ncbi.nlm.nih.gov/34029099
https://pubmed.ncbi.nlm.nih.gov/34029099
Autor:
James A. Bull, Stephanie Greed, Hannah R Cudmore, Charlotte M Zammit, Charlotte Leinfellner, Gregory B. Craven, Ruth R Tweedy, Alexander McDermott, Renzo Luisi, Edward L. Briggs, Dominic P. Affron, Alan Armstrong
Vinyl sulfones and sulfonamides are valued for their use as electrophilic warheads in covalent protein inhibitors. Conversely, the S(VI) aza-isosteres thereof, vinyl sulfoximines and sulfonimidamides, are far less studied and have yet to be applied t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ed71366eee5439b33e03cebdbd8799
http://hdl.handle.net/10044/1/89673
http://hdl.handle.net/10044/1/89673
Autor:
Juan J, Rojas, Rosemary A, Croft, Alistair J, Sterling, Edward L, Briggs, Daniele, Antermite, Daniel C, Schmitt, Luka, Blagojevic, Peter, Haycock, Andrew J P, White, Fernanda, Duarte, Chulho, Choi, James J, Mousseau, James A, Bull
Publikováno v:
Nature chemistry. 14(2)
Bioisosteres provide valuable design elements that medicinal chemists can use to adjust the structural and pharmacokinetic characteristics of bioactive compounds towards viable drug candidates. Aryl oxetane amines offer exciting potential as bioisost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13357918576733615269561f43d59721
https://pubmed.ncbi.nlm.nih.gov/35087219
https://pubmed.ncbi.nlm.nih.gov/35087219
Autor:
Stephanie Greed, Edward L. Briggs, Fahima Idiris, Andrew J. P. White, Ulrich Lücking, James Bull
Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for additional directional interactions. Here we present the first modular enantioselective synthesis of sulfonimidamides, including the first stereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad784c0b69d00b1838565afc2ae90267
http://hdl.handle.net/10044/1/80122
http://hdl.handle.net/10044/1/80122
Autor:
Leonardo Degennaro, James A. Bull, Michelle Afonso, Edward L. Briggs, Arianna Tota, Gala Ogalla Estévez, Sahra St John-Campbell, Renzo Luisi
Publikováno v:
Organic Letters. 20:2599-2602
Aryl thiols can be selectively converted to sulfonimidates or sulfonamides with three new S-X connections being made selectively in one pot. Using hypervalent iodine reagents in the presence of ammonium carbamate, NH- and O-groups are transferred und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1e521f7e83f04cdfce84548c333b05
https://doi.org/10.1021/acs.orglett.8b00788
https://doi.org/10.1021/acs.orglett.8b00788
Autor:
James A. Bull, Renzo Luisi, Edward L. Briggs, Leonardo Degennaro, Marco Colella, Arianna Tota
Sulfonimidamides are intriguing new motifs for medicinal and agrochemistry, and provide attractive bioisosteres for sulfonamides. However, there remain few operationally simple methods for their preparation. Here, for the first time the synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a99d05768c25e91192d1da64a0a3a8
http://hdl.handle.net/10044/1/72388
http://hdl.handle.net/10044/1/72388