Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Edward L, Huttlin"'
Autor:
Jonas D. Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H. Christensen, Joao A. Paulo, Robin Antrobus, Steven P. Gygi, Florian I. Schmidt, Edward L. Huttlin, Geoffrey L. Smith, Michael P. Weekes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral proteins
Externí odkaz:
https://doaj.org/article/c5eb5a2f13b44fa3a6446d25a2216f50
Autor:
Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impac
Externí odkaz:
https://doaj.org/article/cd1a101b49ee4dfbb34edecc65790389
Autor:
Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Federica Mescia, Laura Bergamaschi, Fernando J. Calero-Nieto, Robin Antrobus, James Williamson, Harriet Parsons, Edward L. Huttlin, Nathalie Kingston, Berthold Göttgens, John R. Bradley, Paul J. Lehner, Nicholas J. Matheson, Kenneth G.C. Smith, Mark R. Wills, Paul A. Lyons, Michael P. Weekes
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112613- (2023)
Summary: Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mecha
Externí odkaz:
https://doaj.org/article/c7326025d3cb4f20b0a4a053867e6734
Autor:
Monica J. Bohmer, Jinhua Wang, Eva S. Istvan, Madeline R. Luth, Jennifer E. Collins, Edward L. Huttlin, Lushun Wang, Nimisha Mittal, Mingfeng Hao, Nicholas P. Kwiatkowski, Steven P. Gygi, Ratna Chakrabarti, Xianming Deng, Daniel E. Goldberg, Elizabeth A. Winzeler, Nathanael S. Gray, Debopam Chakrabarti
Publikováno v:
ACS Infectious Diseases. 9:1004-1021
Autor:
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Publikováno v:
eLife, Vol 8 (2019)
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, a
Externí odkaz:
https://doaj.org/article/d9cf04ffe19c4d6392dcfe47e0a4c2a3
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 2092-2104.e4 (2019)
Summary: Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous
Externí odkaz:
https://doaj.org/article/e6bdb40d5e5345cab18cd3481ab38e15
Publikováno v:
Bioinformatics. 39
SummaryThe BioPlex project has created two proteome scale, cell-line-specific protein–protein interaction (PPI) networks: the first in 293T cells, including 120k interactions among 15k proteins; and the second in HCT116 cells, including 70k interac
Autor:
Dylan C. Mitchell, Miljan Kuljanin, Jiaming Li, Jonathan G. Van Vranken, Nathan Bulloch, Devin K. Schweppe, Edward L. Huttlin, Steven P. Gygi
Publikováno v:
Nature Biotechnology.
Autor:
Brandon M. Gassaway, Jiaming Li, Ramin Rad, Julian Mintseris, Kyle Mohler, Tyler Levy, Mike Aguiar, Sean A. Beausoleil, Joao A. Paulo, Jesse Rinehart, Edward L. Huttlin, Steven P. Gygi
Publikováno v:
Nat Methods
Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role of protein phosphorylation, the field still lacks inexpensive, regenerable, and diverse ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52469f1062cd0a7b82f7270dbfda982
https://europepmc.org/articles/PMC9847208/
https://europepmc.org/articles/PMC9847208/
Autor:
Dylan C, Mitchell, Miljan, Kuljanin, Jiaming, Li, Jonathan G, Van Vranken, Nathan, Bulloch, Devin K, Schweppe, Edward L, Huttlin, Steven P, Gygi
Publikováno v:
Nature biotechnology.
Defining the cellular response to pharmacological agents is critical for understanding the mechanism of action of small molecule perturbagens. Here, we developed a 96-well-plate-based high-throughput screening infrastructure for quantitative proteomi