Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Edward Kazyanskaya"'
Autor:
Nathan Haseley, Michael Fitzgerald, Raymond M. Nietupski, Matthew Thompson, Melanie R. Silvis, Noriaki Iwase, Sarah Schmidt Grant, Carl N. Wivagg, Katherine Gordon, Edward Kazyanskaya, Deborah T. Hung, Tomohiko Kawate, Ashlee M. Earl, Samantha Wellington, Christopher A. Desjardins
Publikováno v:
Cell Chemical Biology. 23(6):666-677
Summary Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least 6 months. Interestingly, many of the antibiotics used to treat M. tuberculosis are prodrugs that require intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359c0b0aa02d83c310de090fff30f40
Autor:
Tomohiko Kawate, John Aquadro, Huanqin Dai, Motohisa Shimizu, Lixin Zhang, Aaron Golas, Michael Fitzgerald, Carl N. Wivagg, Deborah T. Hung, Edward Kazyanskaya, Melanie R. Silvis, Sarah A. Stanley, Sarah Schmidt Grant, Noriaki Iwase
Publikováno v:
ACS Chemical Biology. 7:1377-1384
Despite the urgent need for new antitubercular drugs, few are on the horizon. To combat the problem of emerging drug resistance, structurally unique chemical entities that inhibit new targets will be required. Here we describe our investigations usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d97f73399aa52c5b21613b2a6ebac3
https://doi.org/10.1021/cb300151m
https://doi.org/10.1021/cb300151m
Publikováno v:
Organic Letters. 14:4534-4536
Epidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a0baec5be2b28cbd32d7b83cbf135
https://doi.org/10.1021/ol3020094
https://doi.org/10.1021/ol3020094
Publikováno v:
Tetrahedron Letters. 52:2262-2264
A formal total synthesis of the epidithiodiketopiperazine natural product, dehydrogliotoxin (2), utilizing an intramolecular ring closure to form key intermediate 5 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2125f69ca92a1585f3a45af2cf89b51d
https://doi.org/10.1016/j.tetlet.2011.01.138
https://doi.org/10.1016/j.tetlet.2011.01.138
Autor:
Michael Fitzgerald, Partha P. Nag, Sang-Hyun Cho, Sarah A. Stanley, Deborah T. Hung, Raymond M. Nietupski, Katherine Gordon, Sarah Schmidt Grant, Melanie R. Silvis, Scott G. Franzblau, Edward Kazyanskaya, Tomohiko Kawate, Aaron Golas
Publikováno v:
ACS chemical biology. 8(10)
During Mycobacterium tuberculosis infection, a population of bacteria is thought to exist in a non-replicating state, refractory to antibiotics, which may contribute to the need for prolonged antibiotic therapy. The identification of inhibitors of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8d2ec4b5acfa3819d2d66a265f16e5
https://pubmed.ncbi.nlm.nih.gov/23898841
https://pubmed.ncbi.nlm.nih.gov/23898841
Autor:
Deborah T. Hung, Noriaki Iwase, Sarah A. Stanley, Motohisa Shimizu, Edward Kazyanskaya, Tomohiko Kawate, Samantha Wellington
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(22)
In an effort to develop new and potent agents for therapy against tuberculosis, a high-throughput screen was performed against Mycobacterium tuberculosis strain H37Rv. Two 6-aryl-5,7-dimethyl-4-phenylcoumarin compounds 1a and 1b were found with modes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337aabac689d0ac7ba52d9b1eec5fa6f
https://pubmed.ncbi.nlm.nih.gov/24103299
https://pubmed.ncbi.nlm.nih.gov/24103299
Autor:
Tomohiko Kawate, Anne E. Clatworthy, Sarah A. Stanley, Motohisa Shimizu, Thomas R. Ioerger, Noman Siddiqi, Noriaki Iwase, James C. Sacchettini, Edward Kazyanskaya, Deborah T. Hung, Sarah Schmidt Grant, John Aquadro, Eric J. Rubin, Shoko Minami
Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to combat the global tuberculosis pandemic; however, the development of new small molecules is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f031abd627b91987de37b3dce16488c0
https://europepmc.org/articles/PMC3710825/
https://europepmc.org/articles/PMC3710825/
