Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Edward K Mandell"'
Autor:
Diana J Uribe, Edward K Mandell, Adam Watson, Jesse D Martinez, Jonathan A Leighton, Sourav Ghosh, Carla V Rothlin
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179979 (2017)
The receptor tyrosine kinases (RTKs) TYRO3, AXL and MERTK (TAM) have well-described oncogenic functions in a number of cancers. Notwithstanding, TAM RTKs are also potent and indispensable inhibitors of inflammation. The combined deletion of Axl and M
Externí odkaz:
https://doaj.org/article/d5f73fbd5390456c828b1d487687d6ba
Autor:
Raymond B. Runyan, Christopher M. Cox, Ruifeng Lu, Sourav Ghosh, Andre L.P. Tavares, Sarah D. McCarter, Debra L. Johnson, Jean M. Wilson, Edward K. Mandell, Lorraine Stewart
Publikováno v:
Molecular Biology of the Cell
It was shown previously that endotubin, an integral membrane protein of endosomes, regulates the trafficking of tight junction proteins between endosomes and the tight junctions. Here it is shown that endotubin regulates YAP localization on endosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a153beb55a39f2deb3f7327e61d6780f
https://doi.org/10.1091/mbc.e15-04-0224
https://doi.org/10.1091/mbc.e15-04-0224
Autor:
Edward K. Mandell, Sourav Ghosh, Ruifeng Lu, Dogukan Dalgalan, Jean M. Wilson, Sara S. Parker
Publikováno v:
Molecular Biology of the Cell
PKCι has an essential role in epithelial polarity. Its knockdown increases epithelial barrier through control of the trafficking of claudin-2. PKCι interacts directly with the small GTPase Rab14, and these proteins colocalize in cells. It is propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4dfb7475e10af3973c2d7423b73d82
http://europepmc.org/articles/PMC4395131
http://europepmc.org/articles/PMC4395131
Autor:
Adam W. Watson, Jonathan A. Leighton, Diana J. Uribe, Sourav Ghosh, Carla V. Rothlin, Jesse D. Martinez, Edward K. Mandell
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0179979 (2017)
PLoS ONE, Vol 12, Iss 7, p e0179979 (2017)
The receptor tyrosine kinases (RTKs) TYRO3, AXL and MERTK (TAM) have well-described oncogenic functions in a number of cancers. Notwithstanding, TAM RTKs are also potent and indispensable inhibitors of inflammation. The combined deletion of Axl and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793d5ecfe0848f847c4ce9836ff89436
http://europepmc.org/articles/PMC5519024
http://europepmc.org/articles/PMC5519024
Publikováno v:
Genetics. 193:715-725
Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3cdf28482efa7be362cfc1d4bb5310
https://doi.org/10.1534/genetics.112.147801
https://doi.org/10.1534/genetics.112.147801
Autor:
Frank Porreca, Alec Okun, Ohannes K. Melemedjian, Theodore J. Price, Irina Y. Maskaykina, Gregory Dussor, Edward K. Mandell, Chaoling Qu, Tamara King, Edita Navratilova, Sourav Ghosh
Publikováno v:
Pain. 153:1263-1273
Injuries can induce adaptations in pain processing that result in amplification of signaling. One mechanism may be analogous to long-term potentiation and involve the atypical protein kinase C, PKMζ. The possible contribution of PKMζ-dependent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dd937163746cebb6d42cd84c815c13
https://doi.org/10.1016/j.pain.2012.03.006
https://doi.org/10.1016/j.pain.2012.03.006
Publikováno v:
Nucleic Acids Research
The Est3 subunit of yeast telomerase, which adopts a predicted OB-fold, is essential for telomere replication. To assess the possible contributions that Est3 might make to enzyme catalysis, we compared telomerase activity from wild type and est3-Delt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb1dc5e14dd415a44bc9959d2e21728
https://doi.org/10.1093/nar/gkp1173
https://doi.org/10.1093/nar/gkp1173
Autor:
Eugenio Antonio Carrera-Silva, Anthony S. Perry, Daniel Gibbs, Michael E. Berens, Kenneth Aldape, Andrea Emilse Errasti, Weiwei Yang, Zhimin Lu, Justin Dietrich, Yael Kusne, Edward K. Mandell, Elisabeth J. Rushing, Christopher Hulme, Joseph C. Loftus, Sourav Ghosh, Nader Sanai, Carla V. Rothlin
Publikováno v:
Science signaling. 7(338)
Grade IV glioblastoma is characterized by increased kinase activity of epidermal growth factor receptor (EGFR); however, EGFR kinase inhibitors have failed to improve survival in individuals with this cancer because resistance to these drugs often de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330b66e5b04ab9780090e5bbb772d502
https://pubmed.ncbi.nlm.nih.gov/25118327
https://pubmed.ncbi.nlm.nih.gov/25118327
Autor:
Marina N. Asiedu, Dipti V. Tillu, Jamie K. Moy, Theodore J. Price, Sourav Ghosh, Gregory Dussor, Ohannes K. Melemedjian, Edward K. Mandell
Publikováno v:
Molecular Pain
Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1657733e190b677b3f5cc945f1ba5330
https://pubmed.ncbi.nlm.nih.gov/24993495
https://pubmed.ncbi.nlm.nih.gov/24993495
Autor:
Sophie M. Hapak, Paul A. St. John, Irina Y. Maskaykina, Ji Young Kim, Sara S. Parker, Jamie K. Moy, Yael Kusne, Theodore J. Price, Sourav Ghosh, Jean M. Wilson, Katalin M. Gothard, Edward K. Mandell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(35)
Atypical protein kinase C (aPKC) isoforms ζ and λ interact with polarity complex protein Par3 and are evolutionarily conserved regulators of cell polarity. Prkcz encodes aPKC-ζ and PKM-ζ, a truncated, neuron-specific alternative transcript, and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891cbc4bc0db83c4a4e89b1e1dcb11fa
https://pubmed.ncbi.nlm.nih.gov/23940317
https://pubmed.ncbi.nlm.nih.gov/23940317