Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Edward J. Victoria"'
Autor:
Andrej Sali, G. Michael Iverson, Marc A. Marti-Renom, Steven A. Krilis, Stephen W. Reddel, Ying-Xia Wang, David M. Marquis, Keith A. Cockerill, Matthew D. Linnik, Edward J. Victoria
Publikováno v:
The Journal of Immunology. 169:7097-7103
Autoantibodies against β2-glycoprotein I (β2GPI) appear to be a critical feature of the antiphospholipid syndrome (APS). As determined using domain deletion mutants, human autoantibodies bind to the first of five domains present in β2GPI. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d73a219833e57ab55a5cefd423fa298
https://doi.org/10.4049/jimmunol.169.12.7097
https://doi.org/10.4049/jimmunol.169.12.7097
Autor:
Christina A. Gamino, Huong-Thu Ton-Nu, Matthew D. Linnik, Edward J. Victoria, Stephen M. Coutts, M. E. Randow, G. M. Iverson, David S. Jones
Publikováno v:
Bioconjugate Chemistry. 10:480-488
Antibodies which bind beta2-glycoprotein I (beta2GPI) are associated with antiphospholipid syndrome. Synthetic peptide mimotopes have been discovered which compete with beta2GPI for binding to selected anti-beta2GPI. A thiol-containing linker was att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5712ea4f17b9ae2379315fd5e534bcf6
https://doi.org/10.1021/bc9801373
https://doi.org/10.1021/bc9801373
Autor:
Edward J. Victoria, Brian L. Baker, Daniel S. Sem, Stephen Coutts, Joshua Parks, Lin Yu, David S. Jones, David M. Marquis
Publikováno v:
Biochemistry. 37:16069-16081
The presence of high titers of anti-cardiolipin antibodies (ACA's) of autoimmune origin, which are known to bind to plasma beta2-glycoprotein I (aka apolipoprotein H), correlates clinically with autoimmune recurrent thrombosis. Soluble beta2-glycopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324104882921ce7fe80eb1a4c94d662a
https://doi.org/10.1021/bi9807207
https://doi.org/10.1021/bi9807207
Autor:
Martina E Randow, Christina A. Gamino, David S. Jones, Lin Yu, Edward J. Victoria, Stephen Coutts
Publikováno v:
Tetrahedron Letters. 39:6107-6110
Thioether cyclized peptide analogue, 1 , was synthesized using solid phase FMOC chemistry on HMPB-MBHA resin. α-Methylproline was introduced as an FMOC-alanyl-α-methylproline dipeptide, and the thioether was incorporated as FMOC-protected thioether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07eebc38a39ea5e5c032a975cfbd28b7
https://doi.org/10.1016/s0040-4039(98)01292-1
https://doi.org/10.1016/s0040-4039(98)01292-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2129-2132
A series of mechanism-based inhibitors of phospholipase A2 (SIBLINKS) were synthesized. These new SIBLINKS are phospholipid analogues that contain a para-substituted phenyl 3,3-dimethylglutaryl group in the place of the sn-2 acyl chain. The effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f24e41c83db1bb32682f3f9adfde99b
https://doi.org/10.1016/s0960-894x(98)00378-3
https://doi.org/10.1016/s0960-894x(98)00378-3
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 343(1-2)
Understanding so-called anticardiolipin autoantibodies has been the focus of significant interest due to their accepted role in the pathology of antiphospholipid syndrome (APS). How these antibodies contribute to thrombosis, stroke and recurrent feta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac8f1119f2818e69786d380799ddbc2
https://pubmed.ncbi.nlm.nih.gov/15115676
https://pubmed.ncbi.nlm.nih.gov/15115676
Autor:
Merle S. Hayag, Edward J. Victoria, Eric M. Smith, Michael J. Branks, Matthew D. Linnik, Mary-Ann Campbell, David S. Jones, Keith A. Cockerill
Publikováno v:
International immunopharmacology. 3(12)
This study investigated the use of well-defined bioconjugate molecules to suppress antigen-specific B cell responses to domain I (DI) of human beta(2)-glycoprotein I (beta(2)GPI) in rats. DI is the dominant target of pathogenic autoimmune antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6790f76983fccdf6fd9eee908024ea19
https://pubmed.ncbi.nlm.nih.gov/14555291
https://pubmed.ncbi.nlm.nih.gov/14555291
Publikováno v:
Journal of autoimmunity. 18(4)
(Beta2-glycoprotein I (beta2GPI) is a plasma protein that plays an important role in the antigenic specificity of antiphospholipid autoantibodies (aPL). These antibodies are associated with an increased risk for thrombosis and recurrent foetal loss i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9a20d71c50251d10f2283f46b4369f
https://pubmed.ncbi.nlm.nih.gov/12144810
https://pubmed.ncbi.nlm.nih.gov/12144810
Autor:
Patricia A. McNeeley, Merle S. Hayag, Keith A. Cockerill, Christina A. Gamino, Jeffrey R. Hammaker, David S. Jones, G. Michael Iverson, Matthew D. Linnik, Edward J. Victoria, and Huong-Thu Ton-Nu, Martina E. Tedder
Publikováno v:
Bioconjugate chemistry. 12(6)
LJP 993, a tetravalent conjugate of the amino-terminal domain (domain 1) of beta2GPI, was synthesized, and studies were carried out to explore the ability of LJP 993 to bind anti-beta2GPI antibodies and to function as a B cell toleragen. Domain 1 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5b3014bee005d8a341ff39270499f4
https://pubmed.ncbi.nlm.nih.gov/11716694
https://pubmed.ncbi.nlm.nih.gov/11716694
Anticardiolipin (aCL) autoantibodies are associated with thrombosis, recurrent fetal loss, and thrombocytopenia. Only aCL found in autoimmune disease require the participation of the phospholipid binding plasma protein beta2 glycoprotein I (beta2GPI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585447a80dbd2b057392ff87394781bd
https://europepmc.org/articles/PMC28079/
https://europepmc.org/articles/PMC28079/
