Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Edward J. Shillitoe"'
Autor:
Edward J. Shillitoe
Publikováno v:
Critical reviews in oncogenesis. 23(3-4)
The pathogenesis of oral cancer is complex, and not all relevant factors involved in it have been determined. In particular, the role of the microbiota is not well understood because of difficulties in isolating and culturing its organisms. However,
Autor:
Edward J. Shillitoe
Publikováno v:
Oral Oncology. 45:351-355
The development of squamous cell carcinomas of the oropharyngeal mucosa may involve many factors, including viruses. This review examines the evidence that viruses could be involved in the etiology of oral cancer, and shows that the evidence for a ro
Publikováno v:
International Journal of Cancer. 119:2113-2118
Electroporation-based mono-gene therapy has received great interest in recent years but coadministration of different therapeutic genes for treatment of tumors has not been well explored. We hypothesize that electroporation is capable of delivering m
Autor:
Sandra Gibson, Edward J. Shillitoe
Publikováno v:
Journal of Oral Pathology and Medicine. 35:146-154
Background: Cancer cells can resist apoptosis that is induced by stimuli such as detachment or differentiation, but may be more susceptible to apoptosis when exposed to chemotherapeutic drugs. The pattern of gene expression that produces this phenoty
Autor:
Adel K. El-Naggar, John F. Ensley, George H. Yoo, Edward J. Shillitoe, Jeffrey N. Myers, Abelardo Meneses-García, Haven Baker, Vyomesh Patel, William S. Hancock, Jorge S. Gutkind, Alfredo A. Molinolo
Publikováno v:
Oral Oncology. 41:183-199
Remarkable progress has been made to identify genes expressed in squamous cell carcinomas of the head and neck (HNSCC). However, limited information is available on their corresponding protein products, whose expression, post-translational modificati
Publikováno v:
Oral Diseases. 9:305-312
Objective The murine AT-84 orthotopic model of oral cancer was assessed to find how similar it is to human oral cancer. This was done because testing of new treatments for oral cancer requires the use of a realistic animal model. Materials and method
Publikováno v:
Journal of Oral Pathology & Medicine. 31:125-133
In normal oral epithelium the cells divide, mature, differentiate, and die. This sequence is not normally followed in oral cancer. Instead, the death of the cells is somehow prevented, although the pathways toward cell death in normal oral epithelium
Autor:
M. May, Edward J. Shillitoe, Jorge S. Gutkind, Vyomesh Patel, John F. Ensley, R.L. Strausberg, C. Lethanakul
Publikováno v:
Oral Oncology. 36:8-16
The Cancer Genome Anatomy Project (CGAP) is a large cooperative effort sponsored by the US National Institutes of Health designed to find, catalog and annotate genes that are expressed during cancer development. In the past 2 years, the CGAP has sequ
Publikováno v:
Journal of Virology. 73:5326-5332
A mutagenesis system was developed for the in vivo study of the fidelity of DNA replication mediated by wild-type herpes simplex virus type 1 (HSV-1) strain KOS and its polymerase (Pol) mutant derivatives PAA r 5, Y7, and YD12. The pHOS1 shuttle plas
Publikováno v:
Oral Oncology. 35:326-332
The herpes simplex virus type-1 (HSV-1) might be useful in treatment of oral cancer because it is strongly cytolytic, and its natural target tissue is the source of oral squamous cell carcinomas. Use of a wild-type virus would be limited by its sprea