X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

Autor: Qiming Yang, Te-Wen Lo, Katjuša Brejc, Caitlin Schartner, Edward J Ralston, Denise M Lapidus, Barbara J Meyer

Publikováno v: eLife, Vol 12 (2023)

An evolutionary perspective enhances our understanding of biological mechanisms. Comparison of sex determination and X-chromosome dosage compensation mechanisms between the closely related nematode species Caenorhabditis briggsae (Cbr) and Caenorhabd

Externí odkaz: https://doaj.org/article/526018a47b764e0889330ab11462566c

Author response: X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

Autor: Te-Wen Lo, Qiming Yang, Katjuša Brejc, Caitlin Schartner, Edward J Ralston, Denise M Lapidus, Barbara J Meyer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0987506a22ea0848fc3b1fa3ba45a48a
https://doi.org/10.7554/elife.85413.sa2

Combinatorial clustering of distinct DNA motifs directs synergistic binding ofCaenorhabditis elegansdosage compensation complex to X chromosomes

Autor: Nicholas J. Fuda, Katjuša Brejc, William S. Kruesi, Edward J. Ralston, Rachel Bigley, Aram Shin, Miki Okada, Barbara J. Meyer

Publikováno v: Proceedings of the National Academy of Sciences. 119

Organisms that count X-chromosome number to determine sex utilize dosage compensation mechanisms to balance X-gene expression between sexes. Typically, a regulatory complex is recruited to X chromosomes of one sex to modulate gene expression. A major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96516524fc59f629a48660c8f5981503
https://doi.org/10.1073/pnas.2211642119

Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions

Autor: Edward J. Ralston, Qian Bian, Caitlin M. Schartner, Catherine S. Pickle, Mark Gurling, Jennifer A. Doudna, Te Wen Lo, Barbara J Meyer, Steven Lin

Publikováno v: Lo, TW; Pickle, CS; Lin, S; Ralston, EJ; Gurling, M; Schartner, CM; et al.(2013). Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics, 195(2), 331-348. doi: 10.1534/genetics.113.155382. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/268787zz

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde63efb1a69deb51bc28eb8c1e664f1
https://doi.org/10.1534/genetics.113.155382

Sex and X-Chromosome-wide Repression in C. elegans

Autor: Edward J. Ralston, Barbara J Meyer, Patrick McDonel, Györgyi Csankovszki

Publikováno v: Cold Spring Harbor Symposia on Quantitative Biology. 69:1-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4e69a5bfec9bcaf6309cbbf7babc514
https://doi.org/10.1101/sqb.2004.69.45