Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Edward J. Olhava"'
Autor:
Michael W.M. Kühn, Michael J. Hadler, Scott R. Daigle, Richard P. Koche, Andrei V. Krivtsov, Edward J. Olhava, Michael A. Caligiuri, Gang Huang, James E. Bradner, Roy M. Pollock, Scott A. Armstrong
Publikováno v:
Haematologica, Vol 100, Iss 5 (2015)
Externí odkaz:
https://doaj.org/article/dcb0db050f0649f7b220df543be1f0a0
Autor:
Scott R. Daigle, Kathrin M. Bernt, Stephen J. Blakemore, Robert A. Copeland, Jesse J. Smith, Roy M. Pollock, Edward J. Olhava, Nigel J. Waters, Taylor Yamauchi, Michael J. Maria, Ty M. Thomson, David A. Drubin, Jessica N. Haladyna, Carly T. Campbell
Contains the mechanism footprint gene list referenced by supplemental Table S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b27a0f3e74bce3707a37643b0d7252
https://doi.org/10.1158/1535-7163.22508665.v1
https://doi.org/10.1158/1535-7163.22508665.v1
Autor:
Scott R. Daigle, Kathrin M. Bernt, Stephen J. Blakemore, Robert A. Copeland, Jesse J. Smith, Roy M. Pollock, Edward J. Olhava, Nigel J. Waters, Taylor Yamauchi, Michael J. Maria, Ty M. Thomson, David A. Drubin, Jessica N. Haladyna, Carly T. Campbell
Contains supplemental methods, figures, and tables 1, 2, 3, and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e37128c2af18c9c04b6058c16e62d2
https://doi.org/10.1158/1535-7163.22508668
https://doi.org/10.1158/1535-7163.22508668
Autor:
Nigel J. Waters, Angelos Dovletoglou, Tyler B. Jensen, Scott R. Daigle, Edward J. Olhava, Brett Franklin Truitt, Aravind Basavapathruni, Carly T. Campbell, Kim Stickland, Roy M. Pollock, Bruce N. Rehlaender
Publikováno v:
Journal of Controlled Release. 220:758-765
Protein methyltransferases are emerging as promising drug targets for therapeutic intervention in human cancers. Pinometostat (EPZ-5676) is a small molecule inhibitor of the DOT1L enzyme, a histone methyltransferase that methylates lysine 79 of histo
Autor:
Edward J. Olhava, Nigel J. Waters, J. Joshua Smith, David A. Drubin, Kathrin M. Bernt, Jessica Haladyna, Taylor Yamauchi, Roy M. Pollock, Carly T. Campbell, Timothy M. Thomson, Stephen J. Blakemore, Robert A. Copeland, Michael J. Maria, Scott R. Daigle
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its ectopic methylation of histones associated with well-characterized leukemic genes. Pinometostat (EPZ-5676), a selective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491811da5d2182c90ac4d61fbdfb59f0
http://hdl.handle.net/10261/174363
http://hdl.handle.net/10261/174363
Autor:
J. Joshua Smith, L. Danielle Johnston, Edward J. Olhava, Carly A Campbell, Robert A. Copeland, Mikel P. Moyer, Margaret Porter Scott, Scott R. Daigle, Dorothy Iwanowicz, Alejandra Raimondi, Roy M. Pollock, Christine Klaus
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:646-656
EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol], a small-molecule inhibitor of the protein methyltransferase DOT1L, is cur
Autor:
Edward J. Olhava, Angelos Dovletoglou, Christina J. Allain, Nigel J. Waters, Richard Chesworth, Aravind Basavapathruni, Alejandra Raimondi, Roy M. Pollock, Carly A. Therkelsen, Paul G. Pearson, Lei Jin, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, P. Ann Boriack-Sjodin, Christine Klaus, Margaret Porter Scott, Scott R. Daigle
Publikováno v:
Biopharmaceutics & Drug Disposition. 35:237-252
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol (EPZ-5676) is a novel DOT1L histone methyltransferase inhibitor currently in clinical
Autor:
Carly A. Therkelsen, Alejandra Raimondi, Roy M. Pollock, Margaret Porter Scott, Scott R. Daigle, Robert A. Copeland, Mikel P. Moyer, Aravind Basavapathruni, Edward J. Olhava, Christina J. Allain, Lei Jin, Christine Klaus, Richard Chesworth, Nigel J. Waters, Victoria M. Richon, P. Ann Boriack-Sjodin
Publikováno v:
Blood. 122:1017-1025
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a pressing need for new therapies for this disease. Genetic and small m
Autor:
Carly T, Campbell, Jessica N, Haladyna, David A, Drubin, Ty M, Thomson, Michael J, Maria, Taylor, Yamauchi, Nigel J, Waters, Edward J, Olhava, Roy M, Pollock, Jesse J, Smith, Robert A, Copeland, Stephen J, Blakemore, Kathrin M, Bernt, Scott R, Daigle
Publikováno v:
Molecular cancer therapeutics. 16(8)
DOT1L is a protein methyltransferase involved in the development and maintenance of
Autor:
Natalie Warholic, Christina R. Majer, Christopher J. Sneeringer, Christina J. Allain, Edward J. Olhava, Mikel P. Moyer, Sarah K. Knutson, Heike Keilhack, J. Joshua Smith, Lei Jin, Joelle D. Sacks, Robert A. Copeland, Tim J. Wigle, Richard Chesworth, Margaret Porter Scott, Jeffrey Song, Alejandra Raimondi, Kevin Wayne Kuntz, Roy M. Pollock, Victoria M. Richon, Christine Klaus
Publikováno v:
Nature Chemical Biology. 8:890-896
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive H3K27 hypertrimethylation. Here we report the discovery of EPZ005687, a po