Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Edward J. Natoli"'
Autor:
Tibor Keler, Lawrence J. Thomas, Colleen Patterson, Edward J. Natoli, Russell A. Hammond, Joel Goldstein, Laura Mills-Chen, Taylor Mathieu, Jeffrey Weidlick, Michael B. Murphy, Crystal Sisson, Diego Alvarado, Eric Forsberg, James M. Boyer, Li-Zhen He, Linda Crew, Jay S. Lillquist, Jenifer Widger, Thomas O'Neill, Henry March, Andrea Crocker, Amelia Fields, Anna Wasiuk, April R. Baronas, Laura Vitale
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Axl is a member of the TAM (Tyro3/Axl/MerTK) family of receptor tyrosine kinases and a negative regulator of innate immunity. Activation of Axl through its ligand Gas6 leads to suppression of myeloid cell activity, while its activation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5894ba27b16d12cef0d11b14ce02d5
https://doaj.org/article/c5b3f02237404c0b84026e473386f585
https://doaj.org/article/c5b3f02237404c0b84026e473386f585
Autor:
Tibor Keler, Colleen Patterson, Laura Mills-Chen, James L. Boyer, Thomas O'Neill, Anna Wasiuk, Diego Alvarado, Andrea Crocker, Michael T. Murphy, Joel Goldstein, Lawrence J. Thomas, Linda Crew, Jay S. Lillquist, Jenifer Widger, Edward J. Natoli, Henry C. Marsh, Jeff Weidlick, Laura Vitale
Publikováno v:
Cancer Research. 81:1865-1865
Activation of innate immunity using targeted therapies has become an attractive approach to stimulate antitumor responses. Dual inhibition of receptors that suppress myeloid and T cell compartments through the generation of bispecific antibodies (bsA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7b3817e4b60b31879adf5e36e81fc0
https://doi.org/10.1158/1538-7445.am2021-1865
https://doi.org/10.1158/1538-7445.am2021-1865
Autor:
Sangwon Lee, Diego Alvarado, Jay S. Lillquist, Gwenda F. Ligon, Edward J. Natoli, Yaron R. Hadari, Joseph Amick, Joseph Schlessinger, Etienne B Greenlee
ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231fbe8e10bf4d048f380dff10a0a5b7
https://europepmc.org/articles/PMC4629334/
https://europepmc.org/articles/PMC4629334/
Autor:
Edward J. Natoli, Gwenda F. Ligon, Xiarong Shi, Irit Lax, Ewa Folta-Stogniew, Joseph Schlessinger, Andrey V. Reshetnyak, Jay S. Lillquist, Diego Alvarado, Murat Gunel, Phillip B. Murray
Publikováno v:
Science Signaling. 8
Anaplastic lymphoma kinase (ALK) is one of the few remaining "orphan" receptor tyrosine kinases (RTKs) in which the ligands are unknown. Ligand-mediated activation of RTKs is important throughout development. ALK is particularly relevant to the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c7d90cd088b481b277dec5579eb096
https://doi.org/10.1126/scisignal.2005916
https://doi.org/10.1126/scisignal.2005916
Publikováno v:
Current Protocols in Toxicology
Oxygen consumption measurements provide information on the activity of the mitochondrial electron transport chain and such measurements can be carried out on both isolated mitochondria and whole cells. Additional information is available on glycolyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d12f94be97d53a10ffa6d89d8349163
https://doi.org/10.1002/0471140856.tx0216s40
https://doi.org/10.1002/0471140856.tx0216s40
Publikováno v:
Cytokine. 3:277-283
Tenidap is a new antiarthritic drug of novel chemical structure. This study shows the effects of tenidap on the in vitro synthesis of interleukin 1 (IL-1). IL-1 production by murine peritoneal macrophages was induced either by stimulation with lipopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136568586cb3c0761598eaeec3573ac
https://doi.org/10.1016/1043-4666(91)90495-y
https://doi.org/10.1016/1043-4666(91)90495-y
Autor:
Diego Alvarado, Theresa LaVallee, Sangwon Lee, Jay S. Lillquist, Etienne B Greenlee, Joseph Schlessinger, Edward J. Natoli, Gwenda F. Ligon
Publikováno v:
Cancer Research. 75:1672-1672
ErbB3 signaling plays an important role in the progression of a number of solid tumor types, and is the target of several therapeutic monoclonal antibodies. In cancer, ErbB3 activation can be driven by its ligand Neuregulin, or in its absence, throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8874ea4832b173d1e0c7fc608fb70eea
https://doi.org/10.1158/1538-7445.am2015-1672
https://doi.org/10.1158/1538-7445.am2015-1672
Autor:
H. Wang, Carol B. Donovan, Robbin Alpert, Ronald P. Gladue, Vahe Bedian, Joseph P. Gardner, Edward J. Natoli, Timothy Joseph Paradis, Richard M. Shepard, J. Wentland
Publikováno v:
Journal of Clinical Oncology. 24:2539-2539
2539 Background: CD40 is expressed on B-cells, monocytes, dendritic cells, other normal tissues and tumors. Previous studies showed that CD40 stimulation enhances antigen presentation, breaks tolerance, bypasses T-cell help, and induces apoptosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ca79306a2740f9d5763b6c75e35b09
https://doi.org/10.1200/jco.2006.24.18_suppl.2539
https://doi.org/10.1200/jco.2006.24.18_suppl.2539
Autor:
Herbert F. Oettgen, Philip O. Livingston, Lloyd J. Old, Elisabeth Stockert, Michele Jones Calves, Edward J. Natoli
Publikováno v:
Proceedings of the National Academy of Sciences. 84:2911-2915
GM2, GD2, and GD3 gangliosides are expressed on the surface of human melanoma cells and represent potential targets for immunological control of melanoma growth by monoclonal antibodies and active immunization. The immunogenicity of GM2 was investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e2013d1dab93f325dc1c1177787ec
https://doi.org/10.1073/pnas.84.9.2911
https://doi.org/10.1073/pnas.84.9.2911