Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Edward J. Mroszczak"'
Autor:
Claudia VanSaders, Alice B. Gottlieb, Daniela Jabes, Ellen Kelly, Edward J. Mroszczak, Mary Beth Dorr, Giorgio Mosconi, Kathleen C. M. Campbell, Anton Leighton
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:940-945
Fifty-two healthy adult male and female volunteers were enrolled in this double-blind study to determine the maximum tolerated dose, characterize the pharmacokinetics, and obtain serum bactericidal activity (SBA) data for intravenous dalbavancin. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7089bad9c7761333115e2d3c55c18d
https://doi.org/10.1128/aac.48.3.940-945.2004
https://doi.org/10.1128/aac.48.3.940-945.2004
Autor:
Daniel Combs, Yuen Tam, Irene Tsina, Edward J. Mroszczak, Thomas Tarnowski, Aileen E. Boyd, Melvin Chaplin, Cynthia Rocha, Linval Depass, John A. Young
Publikováno v:
Journal of clinical pharmacology. 36(6)
It has been shown that the analgesic and cyclooxygenase inhibitor activity of ketorolac tromethamine (KT), which is marketed as the racemic mixture of (-)S and (+)R enantiomers, resides primarily with (-)S ketorolac and that the ulcerogenic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935bbb1dd77fae51b0b1540791f280a
https://pubmed.ncbi.nlm.nih.gov/8809637
https://pubmed.ncbi.nlm.nih.gov/8809637
Publikováno v:
Journal of clinical pharmacology. 30(1)
The elderly are likely candidates to receive analgesics for pain from a variety of etiologies. Ketorolac tromethamine is a nonsteroidal, analgesic, anti-inflammatory, antipyretic investigational drug with anti-prostaglandin synthetase activity. Sixte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18e0fc8bd431680798008d749dad6e
https://pubmed.ncbi.nlm.nih.gov/2303585
https://pubmed.ncbi.nlm.nih.gov/2303585
Publikováno v:
International Journal of Pharmaceutics. 7:245-260
The absorption of a 75 mg dose of tiopinac, a non-steroidal anti-inflammatory agent, given orally as: (a) a solution; (b) capsules containing milled tiopinac; (c) capsules containing coarse topinac; and (d) capsules containing the sodium salt was eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d1be2669824690cbf8f9de11d3604f
https://doi.org/10.1016/0378-5173(81)90109-5
https://doi.org/10.1016/0378-5173(81)90109-5
Autor:
Sidney Riegelman, Edward J. Mroszczak
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 3:303-327
The biliary excretion and disposition of diethylstilbestrol-14C was studied in an adult male rhesus monkey surgically prepared for chronic use with indwelling arterial-venous catheters as well as permanent catheters to the common bile duct and duoden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a6eebcb2d6cb6d8161b1b5c39e8562
https://doi.org/10.1007/bf01082304
https://doi.org/10.1007/bf01082304
Autor:
Edward J. Mroszczak, Uwe Goebelsmann, Isao Miyakawa, Richard Runkel, Milan R. Henzl, Teck L. Ling, Frank Z. Stanczyk
Publikováno v:
Contraception. 28:241-251
Twenty-four normal adult female volunteers were dosed orally with a solution and tablet formulation containing the contraceptive combination of norethindrone (NET, 1.0 mg) and ethinylestradiol (EE2, 0.12 mg) in a crossover bioequivalence study. Blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3388dc80a90e31e5fa0ef247594dcd36
https://doi.org/10.1016/0010-7824(83)90065-3
https://doi.org/10.1016/0010-7824(83)90065-3
Publikováno v:
Drug Development and Industrial Pharmacy. 3:507-522
A chemical compound in early drug development was used in its radio-labeled form to provide a relation to the physical dosage form characteristics and bioavailability. The 14C-labeled compound, a dibenzthiepin acetic acid derivative, was recrystalliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f755978506b2b606b3b20005d5318f
https://doi.org/10.3109/03639047709055630
https://doi.org/10.3109/03639047709055630
Autor:
Edward J. Mroszczak, Sidney Riegelman
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 6:339-354
The biliary excretion of diethylstilbestrol in the bile fistula rhesus monkey was investigated during exogenous taurocholate- and taurodehydrocholate-induced choleresis. Following intravenous administration, 36% of the dose was excreted into the bile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4e7b51a15f2839a250535894e2d3e6
https://doi.org/10.1007/bf01060097
https://doi.org/10.1007/bf01060097
Publikováno v:
Pharmaceutical Research. :62-65
Ketorolac tromethamine (KT), a potent analgesic with cyclooxygenase inhibitory activity, was administered in an open, randomized, single-dose study of Latin-square design to 12 healthy male volunteers. Doses of 30 mg oral (po) and 30, 60, and 90 mg i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472ce1ac764b06f6e35f4329886a38d7
https://doi.org/10.1023/a:1015803803650
https://doi.org/10.1023/a:1015803803650
Autor:
Sidney Riegelman, Edward J. Mroszczak
Publikováno v:
Clinical Chemistry. 18:987-991
An assay is presented for total bile salts in bile. The procedure involves one precipitation and extraction step and then treatment with concentrated sulfuric acid to produce fluorescent products, which are then measured at an excitation wavelength o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3f32be4bbfb5b1563fbdddf8dce70d
https://doi.org/10.1093/clinchem/18.9.987
https://doi.org/10.1093/clinchem/18.9.987