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pro vyhledávání: '"Edward J. Moticka"'
Autor:
Edward J. Moticka
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedic
Autor:
Edward J. Moticka
Cells of the innate host defense mechanism must differentiate potential pathogens from nonpathogenic material as well as from self. Ilya Metchnikov demonstrated that the macrophage is the initial cell that interacts with foreign material. During the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5a7f6a415f4eb37f7724b1a56dc523
https://doi.org/10.1016/b978-0-12-398381-7.00015-0
https://doi.org/10.1016/b978-0-12-398381-7.00015-0
Autor:
Edward J. Moticka
The adaptive immune system responds specifically to a large number of different antigenic determinants. F. Macfarlane Burnet proposed the clonal selection theory of antibody formation in 1959. One postulate of this theory is that antibody-forming lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff2c2591bfb00c0f57505ad28376eff
https://doi.org/10.1016/b978-0-12-398381-7.00018-6
https://doi.org/10.1016/b978-0-12-398381-7.00018-6
Autor:
Edward J. Moticka
Physicians manipulate the adaptive immune responses to assist patients in overcoming immune-mediated pathologies and to protect against potential pathogenic microorganisms. Even before the discovery of microorganisms, medical practitioners developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f370e2cd71ea6f33a771d5671cb1da
https://doi.org/10.1016/b978-0-12-398381-7.00038-1
https://doi.org/10.1016/b978-0-12-398381-7.00038-1
Autor:
Edward J. Moticka
Thymus-derived lymphocytes perform a variety of functions in the adaptive immune response. These include activating the inflammatory response, helping B lymphocytes produce antibodies, rejecting foreign grafts, eliminating virally infected cells, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::246175e6c026a603c40b26f13e5cd039
https://doi.org/10.1016/b978-0-12-398381-7.00023-x
https://doi.org/10.1016/b978-0-12-398381-7.00023-x
Autor:
Edward J. Moticka
The adaptive immune system functions efficiently to eliminate potential pathogens that escape innate host defenses. Unfortunately, defects of the adaptive system can result in overwhelming infections with a variety of microorganisms. These defects ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e319f5d19ae8423949b68446e7ab53
https://doi.org/10.1016/b978-0-12-398381-7.00032-0
https://doi.org/10.1016/b978-0-12-398381-7.00032-0
Autor:
Edward J. Moticka
Bruce Glick discovered that the bursa of Fabricius, a hindgut, lymphoepithelial structure in chickens, is responsible for the development of antibody-producing B lymphocytes. Glick published his results in 1956; however, they remained obscure for ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b78ecbe6f5375030e0f9adf774f097af
https://doi.org/10.1016/b978-0-12-398381-7.00010-1
https://doi.org/10.1016/b978-0-12-398381-7.00010-1
Autor:
Edward J. Moticka
Physicians have long considered the transplantation of tissue and organs to individuals with various pathologies to be the Holy Grail. Initially they were faced with technical issues such as maintaining viability in organs removed from donors and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0901fd0cb67203a25c031273c41d3f
https://doi.org/10.1016/b978-0-12-398381-7.00036-8
https://doi.org/10.1016/b978-0-12-398381-7.00036-8
Autor:
Edward J. Moticka
The production of antibody and the activation of specifically sensitized T lymphocytes comprise the two mechanisms used by the adaptive immune system to eliminate potentially pathogenic microorganisms. Antibodies bind specifically to structural confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70cce02c778cadbac7f258540faf7c7d
https://doi.org/10.1016/b978-0-12-398381-7.00026-5
https://doi.org/10.1016/b978-0-12-398381-7.00026-5
Autor:
Edward J. Moticka
A tenet of F. Macfarlane Burnet's clonal selection theory is that a potential antibody-forming cell is genetically preprogrammed to synthesize antibodies of a single specificity. Gus Nossal, one of Burnet's colleagues, proposed that the theory could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4f28be9172b67b7d0f2b6d0e9813fc
https://doi.org/10.1016/b978-0-12-398381-7.00007-1
https://doi.org/10.1016/b978-0-12-398381-7.00007-1