Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Edward J. Modest"'
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 9, Pp 1866-1875 (1995)
We have isolated two mutant strains from the murine, macrophage-like cell line, RAW 264.7, that are resistant to the cytotoxic effects of the antineoplastic, platelet activating factor analogue, 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86506a19aff7af2fa961ebf1e9afb76e
http://www.sciencedirect.com/science/article/pii/S0022227520411058
http://www.sciencedirect.com/science/article/pii/S0022227520411058
Publikováno v:
Lipids. 28:189-192
The effect of a serum-free medium (TNB-100), compared to RPMI 1640 containing 10% fetal bovine serum (FBS), on the lipid composition of HL60 and K562 leukemic cells was investigated. The 10% FBS RPMI medium contained approximately three times more ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c370658c211560f83f18c30a2bd11320
https://doi.org/10.1007/bf02536638
https://doi.org/10.1007/bf02536638
Publikováno v:
International Journal of Cancer. 53:124-130
Ether-linked glycerophospholipids (ether lipids, EL) are membrane-interactive drugs selectively cytotoxic toward neoplastic cells compared with normal cells. No conclusive explanation has yet been provided for this selectivity. We now present data in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdcf3179ce8b036642c3d2f809bde7c
https://doi.org/10.1002/ijc.2910530123
https://doi.org/10.1002/ijc.2910530123
Publikováno v:
International Journal of Cancer. 49:409-413
Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ebf76f1c06f31caacce68fb5b3f2a2
https://doi.org/10.1002/ijc.2910490317
https://doi.org/10.1002/ijc.2910490317
Autor:
Fatma Gümüş, Steven Piantadosi, Canio J. Marasco, Jefferson R. Surles, Nathan Iyer, C. Anne Wallen, Louis S. Kucera, Edward J. Modest, Karen L. Meyer, Khalid S. Ishaq, Claude Piantadosi, Susan L. Morris-Natschke
Publikováno v:
Journal of Medicinal Chemistry. 34:1408-1414
Combinations of an amidoalkylphosphocholine, 8, and AZT have been found to cause an apparent synergistic action in suppressing infectious HIV-1 replication. In addition, amidoalkyl, oxyalkyl, and thioalkyl ether lipids have been chemically linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7309aeca611e35c6a407de936e12c1
https://doi.org/10.1021/jm00108a025
https://doi.org/10.1021/jm00108a025
Autor:
W. E. Berdel, W. Ralph Vogler, Susanne Danhauser-Riedl, Gabriela Steinhauser, Alessandro Noseda, Johann Rastetter, Edward J. Modest, Andreas W. Himmelmann, Raymonde Busch
Publikováno v:
Cancer Chemotherapy and Pharmacology. 26:437-443
The synthetic ether lipids ET-18-OCH3 and BM41.440 and a derivative, hexadecylphosphocholine, were tested for inhibition of [3H]-thymidine uptake into a Chinese hamster ovarian cell line (AUXBl) and its multidrug-resistant subline selected for colchi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b052b54544544f70d13e7d8650f97fe
https://doi.org/10.1007/bf02994095
https://doi.org/10.1007/bf02994095
Autor:
Edward J. Modest, Susan L. Morris-Natschke, Karen L. Meyer, Claude Piantadosi, Patrick L. Godwin, Canio J. Marasco, Fiona Rossi
Publikováno v:
Journal of Medicinal Chemistry. 33:1812-1818
Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell line. These compounds contain a positively charged quaternary amine functional group attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175c5f99f23a9d67a1c8a61037556c1d
https://doi.org/10.1021/jm00168a042
https://doi.org/10.1021/jm00168a042
Autor:
Eva S. Leake, Adam Raben, Edward J. Modest, Nathan Iyer, Louis S. Kucera, Larry W. Daniel, Claude Piantadosi
Publikováno v:
AIDS Research and Human Retroviruses. 6:491-501
A new class of membrane-active ether lipid (EL) analogs of platelet-activating factor were studied for in vitro anti-HIV-1 activity. Human T-cell (CEM-ss) monolayers or suspension cultures were used to determine effects of structural modifications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b412ed8ad2f51b3f8baf8ef7863866
https://doi.org/10.1089/aid.1990.6.491
https://doi.org/10.1089/aid.1990.6.491
Autor:
Marina Algeri, Maurizio D'Incalci, Mario Salmona, Luigi Imperatori, Giovanna Damia, Edward J. Modest, Luisa Diomede
Publikováno v:
International journal of cancer. 59(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cbc4e8c412405a536535068f298608
https://pubmed.ncbi.nlm.nih.gov/7960229
https://pubmed.ncbi.nlm.nih.gov/7960229
Publikováno v:
Lipids. 29(4)
The anticancer activity of synthetic ether lipids may depend in part upon their ability to activate cells of the monocyte/macrophage lineage. In the present study, we have sought to determine whether 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphochol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a766cab7f6643132425e771dc22b169e
https://pubmed.ncbi.nlm.nih.gov/8177017
https://pubmed.ncbi.nlm.nih.gov/8177017