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pro vyhledávání: '"Edward J. Masoro"'
Autor:
Edward J. Masoro
Publikováno v:
Dose-Response, Vol 5 (2007)
Caloric restriction (CR) markedly extends the life of rats, mice and several other species, and it also modulates age-associated physiological deterioration and delays the occurrence and/or slows progression of age-associated diseases. The level of C
Externí odkaz:
https://doaj.org/article/05e495fe4816480c8f69896a0c5c0d39
Autor:
Edward J. Masoro, Steven N. Austad
The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper
Autor:
Edward J. Masoro, PhD
This volume provides the non-biologist an overview of what is known about the physiological bases of aging. The author examines the many basic theories and emerging hypotheses underlying the molecular, cellular, and systemic processes involved in sen
Autor:
Edward J. Masoro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:1040-1048
In 1935, Clive McCay and colleagues reported that decreasing the food intake of rats extends their life. This finding has been confirmed many times using rat and mouse models. The responsible dietary factor in rats is the reduced intake of energy; th
Publikováno v:
Aging Clinical and Experimental Research. 18:463-469
Autor:
Edward J. Masoro
Publikováno v:
The Gerontologist. 46:297-300
Autor:
Edward J. Masoro
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 61:14-19
It has long been held that food restriction extends the life span of rodents and other species by decreasing caloric intake and slowing the rate of aging. Recent findings challenge these concepts. This review assesses these controversial issues. The
Autor:
Edward J. Masoro
Publikováno v:
Mechanisms of Ageing and Development. 125:591-594
The deacetylase activity of sirtuin proteins may play a key role in the life extending action of caloric restriction in organisms ranging from yeast to mammals. Recent research has been focused on the possible afferent pathway by which caloric restri
Autor:
James F. Nelson, Randy Strong, Arlan Richardson, Edward J. Masoro, Hanyu Liang, C. Alex McMahan
Publikováno v:
Experimental Gerontology. 38:1353-1364
Since 1996, seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the ‘little mouse’ ( Ghrhr lit/lit ), mice null for either growth hormone receptor/binding protein ( GHR/BP −/− ) or p66 shc ( p6
Autor:
Edward J. Masoro
Publikováno v:
International Journal of Sport Nutrition and Exercise Metabolism. 11:S218-S222
Although physiological deterioration occurs with advancing adult age, the interpretation of cross-sectional and longitudinal studies of age-changes in physiological processes are often complicated by confounders unrelated to aging. Age-associated dis