Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Edward J. Lesnefsky"'
Autor:
Fibi Meshrkey, Kelly M. Scheulin, Christopher M. Littlejohn, Joshua Stabach, Bibhuti Saikia, Vedant Thorat, Yimin Huang, Thomas LaFramboise, Edward J. Lesnefsky, Raj R. Rao, Franklin D. West, Shilpa Iyer
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-appro
Externí odkaz:
https://doaj.org/article/da7822bfd6444abb9d4aa5595fa3c1d7
Autor:
Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100363- (2023)
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the
Externí odkaz:
https://doaj.org/article/ad9e745a75d64f8194bdbfb5527e40ba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury during ischemia (ISC)–reperfusion (REP) by improving mitochondrial functi
Externí odkaz:
https://doaj.org/article/511106f339f74ff489139d02367a3606
Autor:
Migdalia Iglesias, Hao Wang, Meredith Krause-Hauch, Di Ren, Linda Ines Zoungrana, Zehui Li, Jie Zhang, Jin Wei, Nikita Yadav, Kshama Patel, Mohammad Kasim Fatmi, Ruisheng Liu, Edward J. Lesnefsky, Ji Li
Publikováno v:
Cells, Vol 12, Iss 6, p 845 (2023)
Acute kidney injury (AKI) leads to acute cardiac injury and dysfunction in cardiorenal syndrome Type 3 (CRS3) through oxidative stress (OS). The stress-inducible Sestrin2 (Sesn2) protein reduces reactive oxygen species (ROS) accumulation and activate
Externí odkaz:
https://doaj.org/article/78fcdd80594b47158530d2535587dc83
Autor:
Jacob A. Goldsmith, Raymond E. Lai, Ryan S. Garten, Qun Chen, Edward J. Lesnefsky, Robert A. Perera, Ashraf S. Gorgey
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
BackgroundMitochondrial health is an important predictor of several health-related comorbidities including obesity, type 2 diabetes mellitus, and cardiovascular disease. In persons with spinal cord injury (SCI), mitochondrial health has been linked t
Externí odkaz:
https://doaj.org/article/bb42e75c71d547bbbe0dee0b3e3a4988
Autor:
Jiayuan Murphy, Tran Ngoc Van Le, Julia Fedorova, Yi Yang, Meredith Krause-Hauch, Kayla Davitt, Linda Ines Zoungrana, Mohammad Kasim Fatmi, Edward J. Lesnefsky, Ji Li, Di Ren
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
A progressive defect in the energy generation pathway is implicated in multiple aging-related diseases, including cardiovascular conditions and Alzheimer's Disease (AD). However, evidence of the pathogenesis of cardiac dysfunction in AD and the assoc
Externí odkaz:
https://doaj.org/article/5bee6d4f27df471fb67a056e176634c8
Autor:
Raymond E. Lai, Matthew E. Holman, Qun Chen, Jeannie Rivers, Edward J. Lesnefsky, Ashraf S. Gorgey
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Purpose Muscle biopsies are the gold standard to assess mitochondrial respiration; however, biopsies are not always a feasible approach in persons with spinal cord injury (SCI). Peripheral blood mononuclear cells (PBMCs) and near-infrared spectroscop
Externí odkaz:
https://doaj.org/article/90e9ab9dd95a45958c92030c6d67c29e
Autor:
Zachary M. Gertz, MD, Chad Cain, BS, Donatas Kraskauskas, DVM, Teja Devarakonda, BS, Adolfo G. Mauro, PhD, Jeremy Thompson, BS, Arun Samidurai, PhD, Qun Chen, PhD, Sarah W. Gordon, DO, Edward J. Lesnefsky, MD, Anindita Das, PhD, Fadi N. Salloum, PhD
Publikováno v:
JACC. CardioOncology, Vol 1, Iss 2, Pp 221-234 (2019)
Objectives: Because of its multifaceted cardioprotective effects, remote ischemic pre-conditioning (RIPC) was examined as a strategy to attenuate doxorubicin (DOX) cardiotoxicity. Background: The use of DOX is limited by dose-dependent cardiotoxicity
Externí odkaz:
https://doaj.org/article/90f55a04437444ab8fe1fa6edad66e41
Autor:
Xianfei Ji, Jennifer L. Bradley, Guanghui Zheng, Weiwei Ge, Jing Xu, Juntao Hu, Fenglian He, Rabiya Shabnam, Mary Ann Peberdy, Joseph P. Ornato, Qun Chen, Edward J. Lesnefsky, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111743- (2021)
Brain mitochondria are more sensitive to global ischemia compared to heart mitochondria. Complex I in the electron transport chain (ETC) is sensitive to ischemic injury and is a major control point of the rate of ADP stimulated oxygen consumption. Th
Externí odkaz:
https://doaj.org/article/82cb046d56e94fe9a93c5f74b08e924a
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early childhood) mitochondrial disorder with both phenotypic and genetic heterogeneity. The heterogeneous nature of this disorder, based in part on the complexity of mi
Externí odkaz:
https://doaj.org/article/17f6fa0783864f2da69a8b8b4eb89f8e