Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Edward J. Kulbokas"'
Autor:
Evan T. Keller, Izabella Baranowska, Nick Patterson, Jill P. Mesirov, Gerli Pielberg, Michael C. Zody, Claire M. Wade, Nicolette Salmon Hillbertz, Nathan Anderson, Edward J. Kulbokas, Åke Hedhammar, Tara M Biagi, Kenine E. Comstock, Elinor K. Karlsson, Olle Kämpe, Leif Andersson, Kerstin Lindblad-Toh, Göran Andersson, Henrik von Euler, Eric S. Lander
Publikováno v:
Nature Genetics. 39:1321-1328
With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with approximately 27,000 SNPs and show that genome-wide association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0467247ac6b8d950f7ba88e33ef6f350
https://doi.org/10.1038/ng.2007.10
https://doi.org/10.1038/ng.2007.10
Autor:
Kerstin Lindblad-Toh, Edward J. Kulbokas, Manolis Kellis, Todd R. Golub, Xiaohui Xie, Eric S. Lander, Vamsi K. Mootha, Jun Lu
Publikováno v:
Nature. 434:338-345
Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2844325d17c2295b868933cd0440f92d
https://doi.org/10.1038/nature03441
https://doi.org/10.1038/nature03441
Autor:
Edward J. Kulbokas, Stuart L. Schreiber, Michael Kamal, Scott McMahon, Dana J. Huebert, Eric S. Lander, Stefan Bekiranov, Dione K. Bailey, Thomas R. Gingeras, Elinor K. Karlsson, Kerstin Lindblad-Toh, Bradley E. Bernstein
Publikováno v:
Cell. 120:169-181
We mapped histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4 dimethylation for several orthologous human and mouse loci. Both chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701693b5638f0c005adb991834d3c772
https://doi.org/10.1016/j.cell.2005.01.001
https://doi.org/10.1016/j.cell.2005.01.001
Autor:
Mark J. Daly, Michael C. Zody, Edward J. Kulbokas, Andrew Kirby, Claire M. Wade, James C. Mullikin, Eric S. Lander, Kerstin Lindblad-Toh
Publikováno v:
Nature. 420:574-578
Most inbred laboratory mouse strains are known to have originated from a mixed but limited founder population in a few laboratories. However, the effect of this breeding history on patterns of genetic variation among these strains and the implication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::108e94561b4802716f25048278c2301c
https://doi.org/10.1038/nature01252
https://doi.org/10.1038/nature01252
Autor:
Edward J. Kulbokas, David S. Sinasac, Annie E. Baskin-Hill, Andrew Kirby, Mark J. Daly, Karl W. Broman, Joseph H. Nadeau, Eric S. Lander, Jonathan Singer, Colleen M. Croniger, Lindsay C. Burrage
Publikováno v:
PMC
Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome substitution strains (CSSs) is a un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74fb13339c0fb00da508fd5996bc267
http://hdl.handle.net/1721.1/84628
http://hdl.handle.net/1721.1/84628
Autor:
Annie E. Hill, Mark J. Daly, Andrew Kirby, Karl W. Broman, Karl J. Jepsen, Lindsay C. Burrage, Edward J. Kulbokas, William E. O'Brien, Joseph H. Nadeau, Hayden William Courtland, Haifeng Shao, Eric S. Lander, Sheila Ernest, David S. Sinasac
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(50)
The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude of their effects, or the extent to which they int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623eb67f7566efb389490113574ac17e
https://pubmed.ncbi.nlm.nih.gov/19066216
https://pubmed.ncbi.nlm.nih.gov/19066216
Autor:
Tsering Wangchuk, Mayank Kumar, Sharon Stavropoulos, James Cuff, Mostafa Benamara, David DeCaprio, Birhane Hagos, Nathaniel Novod, Tashi Lokyitsang, Nyima Norbu, Jennifer Baldwin, Sabrina M. Stone, Catherine Stone, Geneva Young, Osebhajajeme Egbiremolen, Dawa Thoulutsang, Tanya Mihova, Lisa Kim, Julie Sahalie, Jan Macdonald, Amr Abouelleil, Toby Bloom, Yama Cheshatsang, Carolyne Bardeleben, Qing Yu, Berta Blitshteyn, Tuyen T. Nguyen, Tarjei S. Mikkelsen, Edward Grandbois, Claire M. Wade, John E. Major, Filip Rege, Cindy Nguyen, Andrew Barry, Tracey Honan, Pablo Alvarez, Andy Vo, Manuel Garber, Cristyn Kells, Rachel Mittelman, Lucien Oyono, Norbu Dhargay, Sean M. Sykes, Diallo Ferguson, Tyler Aldredge, Tenchoe Nyima, Todd Sparrow, Daniel S. Hagopian, Christophe Hitte, Andreas Heger, Jane E. Wilkinson, Verneda Ray, Peter Rogov, Ewen F. Kirkness, Jill Falk, Robert Nicol, Christopher Patti, Danielle Perrin, Ted Sharpe, Douglas Smith, Peter Olandt, Matthew Breen, Ali Aslam, Cherylyn Smith, Tara Biagi, Diane Gage, Jean L. Chang, Karen Hughes Miller, Valentine Mlenga, Andrea Horn, Jessie Sloan, Claire M. Healy, Adam Wilson, Ngawang Sherpa, Riza M. Daza, David B. Jaffe, Leonid Boguslavskiy, Jody Camarata, Peter Kisner, William H. Lee, Kunsang Dorjee, M. Husby, Sante Gnerre, Kunsang Gyaltsen, Asha Kamat, Jonathan Butler, Terrance Shea, Alicia Franke, Patrick Cooke, Rayale Rameau, Andrew Zimmer, Gary Gearin, Nabil Hafez, Kerri Topham, Kebede Maru, Chris P. Ponting, Jerome Naylor, Yama Thoulutsang, Keith O'Neill, Jinlei Liu, Manolis Kellis, Claude Bonnet, Claudel Antoine, Passang Dorje, Adal Abebe, Tsamla Tsamla, Michael Kleber, Michael Weiand, Audra Goyette, Rachael Thomas, Lisa Zembek, Atanas Mihalev, Daniel Bessette, Helen Vassiliev, Pasang Bachantsang, Adam Navidi, Kathleen Dooley, Caleb Webber, Pierre Tchuinga, Tashi Bayul, Michael Kamal, Heidi G. Parker, Ben Kanga, Kimberly Dooley, Nadia Calixte, Mostafa Ait-zahra, Niall J. Lennon, Ira Topping, Eric S. Lander, Pieter J. deJong, Nicole R. Allen, Peter An, Boris Boukhgalter, Richard Elong, Thomas E. Landers, Anthony Rachupka, Michael Fitzgerald, Lisa Leuper, William Brockman, Marcia Lara, Susan Faro, Elaine A. Ostrander, Joanne Zainoun, Leigh Anne Hunnicutt, Mark J. Daly, Leanne Hughes, April Cook, Patrick Cahill, Sujaa Raghuraman, Manfred Grabherr, Robert K. Wayne, Adam Brown, Xiaohong Liu, Charles Matthews, Scott Anderson, Margaret Priest, Shailendra Yadav, Evan Mauceli, Kerstin Lindblad-Toh, Patricia Ferreira, Yeshi Lokyitsang, Harindra Arachchi, Alexandre Melnikov, Christina Raymond, James Meldrim, Dmitry Khazanovich, Mieke Citroen, Aaron M. Berlin, Alix Chinh Kieu, John Stalker, Francis Galibert, Noah Duffey, Krista Lance, Louis Meneus, Jennifer Ruth Sadler Hall, Choe Norbu, Pema Tenzing, Richard Marabella, Chee-Wye Chin, Karen Foley, Xiaoping Yang, Nga Nguyen, Tenzin Dawoe, Ryan Hegarty, Julie Rogers, Joseph Graham, Chelsea D. Foley, Leonidas Mulrain, Tsering Wangdi, Karin Decktor, Sarah LeVine, Shuli Yang, Dennis C. Friedrich, Tina Goode, Cecil Rise, Teena Mehta, Laura Ayotte, Michele Clamp, Nicole Stange-Thomann, Annie Lui, Edward J. Kulbokas, Pema Phunkhang, Alan Dupes, Elinor K. Karlsson, Lynne Aftuck, Sahal Osman, Abderrahim Farina, Barry O'Neill, Diana M. Shih, Xiaohui Xie, Lester Dorris, Vijay Venkataraman, Benjamin Jester, Sampath Settipalli, Thu Nguyen, Alville Collymore, Klaus-Peter Koepfli, Senait Tesfaye, Nathan Houde, Susan McDonough, Leo Goodstadt, Glen Munson, Georgia Giannoukos, Jeffrey Chu, Nathan B. Sutter, Sheila A. Fisher, Charlien Jones, Michael C. Zody, Jianying Shi, John P. Pollinger, Mechele Sheehan, Stephen M. J. Searle, Fritz Pierre, Jason Blye, Jean-Pierre Leger, Stuart DeGray
Publikováno v:
Nature. 438(7069)
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3df6edd21cfb2fb7cd4be70aee2841
https://pubmed.ncbi.nlm.nih.gov/16340996
https://pubmed.ncbi.nlm.nih.gov/16340996
Autor:
Laura Elnitski, David B. Jaffe, Jia Li, Marina Alexandersson, Michael J. Morgan, Shiaw Pyng Yang, Robert Baertsch, Claire M. Wade, John Tromp, Michael C. Zody, Terrence S. Furey, Emma Overton-Larty, Stephen D. Brown, Scott Schwartz, Diane M. Dunn, J. P. Leger, Kris A. Wetterstrand, David Torrents, Ratna Shownkeen, Brian Schultz, Kim C. Worley, Richard D. Emes, John Mayer, Tom Landers, Beverley Meredith, Carol Scott, R. J. Weber, Sean R. Eddy, David Kulp, Jun Kawai, J Bailey, Fan Hsu, Diana L. Kolbe, Kirsten McLay, Marc Botcherby, Richard Mott, Tracie L. Miner, Jill P. Mesirov, Cristyn Kells, Michael A. Quail, Melanie M. Wall, Alistair G. Rust, Josep F. Abril, Ian F Korf, Peter An, Roderic Guigó, Abel Ureta-Vidal, Evan Mauceli, L. Steven Johnson, Arian F.A. Smit, Arkadiusz Kasprzyk, Michael C. Wendl, Deanna M. Church, Francis S. Collins, Wayne N. Frankel, Pallavi Eswara, Bin Ma, Robert H. Waterston, Stylianos E. Antonarakis, Edward M. Rubin, John Douglas Mcpherson, Andrew Sheridan, Megan McCarthy, Ming Li, Colin N. Dewey, Justin Deri, Rosie Levine, Matthew Jones, Sheila Dodge, Richard R. Copley, Leo Goodstadt, Shan Yang, Donna Maglott, Jamey Wierzbowski, Nick Goldman, Evgeny M. Zdobnov, Simon G. Gregory, C M Clee, Steven Leonard, Elaine R. Mardis, Simon C. Potter, Sarah Sims, Richard A. Gibbs, Mark S. Guyer, Francesca Chiaromonte, Susan Lucas, Mark Diekhans, Steve Searle, Rachel Ainscough, Jane Peterson, Emmanouil T. Dermitzakis, Robert Nicol, Lucy Matthews, Guy Slater, Adam Felsenfeld, Karen Foley, Lucinda Fulton, Tim Hubbard, Richard K. Wilson, Deana W. LaHillier, W. Richard McCombie, Johanna Thompson, Robert David, John Attwood, Anthony P. West, Jane Rogers, Evan Keibler, Lisa Cook, Raju Kucherlapati, Steven Seaman, William E. Nash, Ian J. Jackson, Jonathan Singer, Axin Hua, Tina Graves, Ted Sharpe, Dudley Wyman, Bruce W. Birren, Stuart McLaren, David Willey, A Joy, Douglas Smith, Alexandre Reymond, Paul Flicek, Simon Cawley, Richa Agarwala, Diane Gage, Evanne Trevaskis, Ginger A. Fewell, Michael R. Brent, Tracy C. Ponce, W. James Kent, Timothy Holzer, Eduardo Eyras, Michael J. O’Connor, Webb Miller, Donna M. Muzny, Andrew von Niederhausern, Inna Dubchak, Eitan E. Winter, Catherine Ucla, Arne Stabenau, Michael N. Nhan, Piero Carninci, Michele Clamp, Pavel A. Pevzner, James Meldrim, Tim Cutts, R. D. Campbell, Joy Davies, Wratko Hlavina, Elinor K. Karlsson, David Haussler, John Burton, Peer Bork, Nicole Stange-Thomann, Mikita Suyama, Mark J. Daly, Ewan Birney, Edward J. Kulbokas, Craig Pohl, James C. Mullikin, Chad Nusbaum, Genís Parra, Jade P. Vinson, Yoshihide Hayashizaki, Sante Gnerre, Eric Berry, Daniel G. Brown, Asif T. Chinwalla, Emmanuel Mongin, Robert B. Weiss, Raymond Wheeler, Andrew Kirby, Yasushi Okazaki, Lior Pachter, Ross C. Hardison, Brian Spencer, Carol J. Bult, Joanne O. Nelson, Pankaj K. Agarwal, Darren Grafham, Gustavo Glusman, Thomas A. Jones, Glenn Tesler, Simon Whelan, James Cuff, Robert S. Fulton, K F Barlow, Jörg Schultz, Matthias S. Schwartz, Alex Poliakov, Jonathan Butler, Bruce A. Roe, Angela S. Hinrichs, Alan Coulson, Kate Montgomery, Eric D. Green, Stephan Beck, Val Curwen, Krishna M. Roskin, Robert W. Plumb, Chris P. Ponting, Ralph Santos, Victor Sapojnikov, Nicolas Bray, Kymberlie H. Pepin, Charles W. Sugnet, Olivier Couronne, Ivica Letunic, Sophie Williams, Kimberly D. Delehaunty, Kerstin Lindblad-Toh, Zemin Ning, Karen Oliver, Toby Bloom, Michael Kamal, Nicholas J. Dickens, Eric S. Lander, Christine Lloyd, Donna Karolchik, Adrienne Hunt
Publikováno v:
Nature, Vol. 420, No 6915 (2002) pp. 520-562
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a37312d8c972e24a67353dfd5e2ad6f
http://ora.ox.ac.uk/objects/uuid:dab3ab6b-6c46-4eb2-822d-01887cdfba9f
http://ora.ox.ac.uk/objects/uuid:dab3ab6b-6c46-4eb2-822d-01887cdfba9f
Autor:
Katie Miller, Thomas J. Hudson, Todd Green, Robin S. McLeod, Sinéad B. O'Leary, Terrye Delmonte, Diane Langelier, Albert Cohen, Sheila Guschwan, Ken Dewar, Alain Bitton, Edward J. Kulbokas, Ellen Winchester, Christine S. Chow, Eric S. Lander, Gordon R. Greenberg, Janet Faith, Mark S. Silverberg, John D. Rioux, Mark J. Daly, Kerstin Lindblad, Katherine A. Siminovitch, Zane Cohen, Nancy Branco, Valerie Stone, Anne M. Griffiths, Gilles Lapointe, Shelley B. Bull, Daniel Gaudet, Kerry Kocher, Hillary Steinhart
Publikováno v:
Nature genetics. 29(2)
Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease. We sought to design a systematic approach for LD mapping and apply it to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b1e92cbc98088ea1cae538aee44888
https://pubmed.ncbi.nlm.nih.gov/12479655
https://pubmed.ncbi.nlm.nih.gov/12479655