Zobrazeno 1 - 1
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pro vyhledávání: '"Edward J. Holson"'
Autor:
Christopher L. Lynch, Janet Lineberger, Julie A. DeMartino, Ping Chen, Scott C. Berk, Margaret A. Cascieri, Gwen Carver, Michael W. Miller, Edward J. Holson, Liya Chen, Martin S. Springer, Sandra L. Gould, Kevin T. Chapman, Jeffrey J. Hale, Karen Holmes, Renee Danzeisen, William A. Schleif, Malcolm MacCoss, Joseph Kessler, Richard J. Budhu, Anthony Carella, Charles G. Caldwell, Christopher A. Willoughby, Lorraine Malkowitz, Daria J. Hazuda, Sander G. Mills, Salvatore J. Siciliano, Emilio A. Emini, Amy Gentry, Keith G. Rosauer
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
The 4-(3-phenylprop-1-yl)piperidine moiety of the 1,3,4-trisubstituted pyrrolidine CCR5 antagonist 1 was modified with electron deficient aromatics as well as replacement of the benzylic methylene with sulfones, gem-difluoromethylenes and alcohols in