Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Edward J. D. Greenwood"'
Autor:
Jarrod Shilts, Thomas W. M. Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J. D. Greenwood, Samuel James Watson, Brian M. Ortmann, Christian M. Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A. Nathan, Stefan Pöhlmann, Nicholas J. Matheson, Paul J. Lehner, Gavin J. Wright
Publikováno v:
PLoS Biology, Vol 21, Iss 2 (2023)
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to Coronavirus Disease 2019 (COVID-19). The spike protein is the largest structural compon
Externí odkaz:
https://doaj.org/article/90f98ee96aff4b489c474fa416cf8b43
Autor:
Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood, Jun Ru Zhan, Gregory Strachan, Rhoda E. Kuc, Duuamene Nyimanu, Janet J. Maguire, Paul J. Lehner, Sanjay Sinha, Anthony P. Davenport
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Williams et al. confirm that human embryonic stem cell-derived cardiomyocytes express the protein machinery critical for SARS-CoV-2 infection and are susceptible to SARS-CoV-2 spike protein pseudotyped virus infection. They further use this platform
Externí odkaz:
https://doaj.org/article/38772e0bff5a4477befd0ea1c3205005
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early stud
Externí odkaz:
https://doaj.org/article/985b50f6b24543619791a2c52c0f7f97
Autor:
Stefan Pöhlmann, Samuel James Watson, Markus Hoffmann, Edward J. D. Greenwood, Thomas W M Crozier, Paul J. Lehner, Gavin J. Wright, Tekle Pauzaite, Christian M. Gawden-Bone, James A. Nathan, Brian Ortmann, Jarrod Shilts, Ildar Gabaev, Ana Teixeira-Silva
SummaryThe interactions between severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead to COVID-19. The spike protein is the largest structural component of the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c745d2a09185fb2899e2caf0a429112f
https://doi.org/10.1101/2021.09.25.461776
https://doi.org/10.1101/2021.09.25.461776
Autor:
Edward J. D. Greenwood, Brian Ortmann, Paul J. Lehner, James A. Nathan, Frank McCaughan, Daniel Kottmann, Ravindra Mahadeva, Wenrui Guo, Linsey Porter, Thomas W M Crozier
Cigarette smoking has multiple serious negative health consequences. However, the epidemiological relationship between cigarette smoking and SARS-CoV-2 infection is controversial; and the interaction between cigarette smoking, airway expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f816399bcd216e9969ce18445f8342
https://doi.org/10.1101/2021.09.08.459428
https://doi.org/10.1101/2021.09.08.459428
Autor:
Robyn Macrae, Paul J. Lehner, Sanjay Sinha, Stuart Bloor, Thomas L Williams, Jun Ru Zhan, Janet J. Maguire, Edward J. D. Greenwood, Duuamene Nyimanu, Maria Colzani, Emma L Robinson, Rhoda E. Kuc, Gregory Strachan, Anthony P. Davenport
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902f4cf437b83bb5a306aec8cc48bf5c
https://www.repository.cam.ac.uk/handle/1810/324054
https://www.repository.cam.ac.uk/handle/1810/324054
Autor:
Fabio T. M. Costa, Paul J. Lehner, Sam J. Wilson, Suzannah J. Rihn, David Robertson, Srikeerthana Kuchi, Quan Gu, Thomas W M Crozier, Alfredo Castello-Palomares, Rute Maria Pinto, Elena Sugrue, Matthew L. Turnbull, Isaric C-Investigators, Colin Loney, Monique Freire Santana, Jay Allan, Luiz Carlos de Lima Ferreira, Spyros Lytras, Antonia Ho, Natalia Cameron-Ruiz, Richard J. Stanton, Ruth F. Jarrett, Vanessa Herder, Arthur Wickenhagen, Innes Jarmson, Bo Wang, Sara Clohisey, Edward Chung Yern Wang, Matthias Marti, Massimo Palmarini, Kenneth Baillie, Marko Noerenberg, Joao Luiz Da Silva Filho, Douglas G. Stewart, Margus Varjak, Edward J. D. Greenwood, Simon Swingler
Cell autonomous antiviral defenses can inhibit the replication of viruses and reduce transmission and disease severity. To better understand the antiviral response to SARS-CoV-2, we used interferon-stimulated gene (ISG) expression screening to reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd517e51ccb503d025f6bea1c5a2cbb
https://doi.org/10.1101/2021.05.05.21256681
https://doi.org/10.1101/2021.05.05.21256681
Autor:
Paul J. Lehner, Akhilesh Jha, James A. Nathan, Thomas Wm Crozier, Guo W, Frank McCaughan, Edward J. D. Greenwood, Coates M, Linsey Porter, McKie M
BackgroundThere are limited effective prophylactic treatments for SARS-CoV-2 infection, and limited early treatment options. Viral cell entry requires spike protein binding to the ACE2 receptor and spike cleavage by TMPRSS2, a cell surface serine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb75a075fc84d42b6342b8417c70a6e
https://doi.org/10.1101/2021.04.23.440619
https://doi.org/10.1101/2021.04.23.440619
Autor:
Adi Naamati, Thomas Wm Crozier, Pehuen Pereyra Gerber, Emily C Horner, Rainer Döffinger, Anne E. Willis, Edward J. D. Greenwood, Anna V. Protasio, Jun R Zhan, Ildar Gabaev, Sara Marelli, Lidia M. Duncan, Nicholas J Matheson, James Ed Thaventhiran, Thomas E. Mulroney, Ana Teixeira-Silva
Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody neutralisation. Plaque assays remain the gold standard, but are imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402db4a87e969e6f6906f7b0e985e3c8
https://doi.org/10.1101/2021.03.22.435957
https://doi.org/10.1101/2021.03.22.435957
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6a0b2837f326dd8f886a2d928229aa