Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Edward J. Brignole"'
Autor:
Sheena Vasquez, Melissa D. Marquez, Edward J. Brignole, Amanda Vo, Sunnie Kong, Christopher Park, Deborah L. Perlstein, Catherine L. Drennan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery to cytosolic and nuclear client proteins via the cytosolic iron-sulfur cluster assembly (CIA
Externí odkaz:
https://doaj.org/article/02d17a462c754d74bb13a10be64ddd48
Autor:
Talya S. Levitz, Miriam Weckener, Ivan Fong, James H. Naismith, Catherine L. Drennan, Edward J. Brignole, Daniel K. Clare, Michele C. Darrow
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The specimen preparation process is a key determinant in the success of any cryo electron microscopy (cryoEM) structural study and until recently had remained largely unchanged from the initial designs of Jacques Dubochet and others in the 1980s. The
Externí odkaz:
https://doaj.org/article/b2580e688193450db37856df424dbc9b
Publikováno v:
Microscopy and Microanalysis. 28:1238-1242
Autor:
Max L. Valenstein, Kacper B. Rogala, Pranav V. Lalgudi, Edward J. Brignole, Xin Gu, Robert A. Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast, David M. Sabatini
Publikováno v:
Nature
The mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating anabolic and catabolic processes in response to environmental cues, including nutrients(1,2). Amino acids signal to mTORC1 through the Rag GTPases, which are regulat
Autor:
Edward J Brignole, Kuang-Lei Tsai, Johnathan Chittuluru, Haoran Li, Yimon Aye, Pawel A Penczek, JoAnne Stubbe, Catherine L Drennan, Francisco Asturias
Publikováno v:
eLife, Vol 7 (2018)
Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses
Externí odkaz:
https://doaj.org/article/5584fcf5814d4af1aea70c4e3427daba
Autor:
Sheena Vasquez, Edward J. Brignole, Melissa D. Marquez, Deborah L. Perlstein, Catherine L. Drennan
Publikováno v:
The FASEB Journal. 36
Autor:
Chenyue Sun, Jin-Hu Dou, Jenna L. Mancuso, Edward J. Brignole, Yi Luo, Phat Vinh Dip, Jeffrey T. Miller, Jian Li, Weizhe Zhang, Nicole J. Libretto, Junliang Sun, Luming Yang, Lucas R. Parent, Tianyang Chen, Maxx Q. Arguilla, Min Chieh Yang, Grigorii Skorupskii, Mircea Dincă, Lei Sun, Jing Kong, Christopher H. Hendon
Publikováno v:
Nature Materials. 20:222-228
Electrically conducting 2D metal–organic frameworks (MOFs) have attracted considerable interest, as their hexagonal 2D lattices mimic graphite and other 2D van der Waals stacked materials. However, understanding their intrinsic properties remains a
Autor:
Andrew D. Gnann, Yuan Xia, Jess Soule, Clara Barthélemy, Jayata S. Mawani, Sarah Nzikoba Musoke, Brian M. Castellano, Edward J. Brignole, Dominique P. Frueh, Daniel P. Dowling
Publikováno v:
The Journal of biological chemistry. 298(10)
Nonribosomal peptide synthetase heterocyclization (Cy) domains generate biologically important oxazoline/thiazoline groups found in natural products, including pharmaceuticals and virulence factors such as some siderophores. Cy domains catalyze conse
Publikováno v:
Journal of structural biology. 214(1)
Ribonucleotide reductase (RNR) is an essential enzyme that converts ribonucleotides to deoxyribonucleotides and is a promising antibiotic target, but few RNRs have been structurally characterized. We present the use of the chameleon, a commercially-a
Autor:
Patricia R. Feliciano, Pablo Mesa, Jeremy G. Koob, Guillermo Montoya, Max J. Kellner, Omar O. Abudayyeh, Edward J. Brignole, Stefano Stella, Ian Slaymaker, Soumya Kannan, Jonathan Strecker, Feng Zhang, Jonathan S. Gootenberg
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108865-(2021)
Slaymaker, I M, Mesa, P, Kellner, M J, Kannan, S, Brignole, E, Koob, J, Feliciano, P R, Stella, S, Abudayyeh, O O, Gootenberg, J S, Strecker, J, Montoya, G & Zhang, F 2019, ' High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage ', Cell Reports, vol. 26, no. 13, pp. 3741-3751.e5 . https://doi.org/10.1016/j.celrep.2019.02.094
Cell Reports, Vol 26, Iss 13, Pp 3741-3751.e5 (2019)
Slaymaker, I M, Mesa, P, Kellner, M J, Kannan, S, Brignole, E, Koob, J, Feliciano, P R, Stella, S, Abudayyeh, O O, Gootenberg, J S, Strecker, J, Montoya, G & Zhang, F 2019, ' High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage ', Cell Reports, vol. 26, no. 13, pp. 3741-3751.e5 . https://doi.org/10.1016/j.celrep.2019.02.094
Cell Reports, Vol 26, Iss 13, Pp 3741-3751.e5 (2019)
Summary: Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI C