Synthesis and crystal structures of 3,6-dihydroxypicolinic acid and its labile intermediate dipotassium 3-hydroxy-6-(sulfonatooxy)pyridine-2-carboxylate monohydrate

Autor: Edward J. Behrman, Sean Parkin

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 6, Pp 623-628 (2021)

A simplified two-step synthesis of 3,6-dihydroxypicolinic acid (3-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid), C6H5NO4 (II), an intermediate in the metabolism of picolinic acid, is described. The crystal structure of II, along with that of a

Externí odkaz: https://doaj.org/article/1009eb6afcc5458d8685e3bfcaae71d6

Serendipitous Discovery of a Competitive Inhibitor of FraB, a Salmonella Deglycase and Drug Target

Autor: Pankajavalli Thirugnanasambantham, Sravya Kovvali, Austin Cool, Yuan Gao, Anice Sabag-Daigle, Erin F. Boulanger, Mark Mitton-Fry, Angela Di Capua, Edward J. Behrman, Vicki H. Wysocki, Steffen Lindert, Brian M. M. Ahmer, Venkat Gopalan

Publikováno v: Pathogens, Vol 11, Iss 10, p 1102 (2022)

Although salmonellosis, an infectious disease, is a significant global healthcare burden, there are no Salmonella-specific vaccines or therapeutics for humans. Motivated by our finding that FraB, a Salmonella deglycase responsible for fructose-aspara

Externí odkaz: https://doaj.org/article/c280ab1c7e0c4598b514097154172a76

Synthesis and crystal structures of 3,6-dihydroxypicolinic acid and its labile intermediate dipotassium 3-hydroxy-6-(sulfonatooxy)pyridine-2-carboxylate monohydrate

Autor: Sean Parkin, Edward J. Behrman

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 6, Pp 623-628 (2021)
Acta Crystallographica Section E: Crystallographic Communications

A two-step synthesis of 3,6-di­hydroxy­picolinic acid, its crystal structure and that of a labile inter­mediate, are described.
A simplified two-step synthesis of 3,6-di­hydroxy­picolinic acid (3-hy­droxy-6-oxo-1,6-di­hydro­pyridine-2-ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ef6653db0a9f37ade8f552d7f62fb2
http://scripts.iucr.org/cgi-bin/paper?S2056989021004904

Characterization of a Salmonella transcription factor-DNA complex and identification of the inducer by native mass spectrometry

Autor: Blake E. Szkoda, Angela Di Capua, Joy Shaffer, Edward J. Behrman, Vicki H. Wysocki, Venkat Gopalan

Publikováno v: J Mol Biol

FraR, a transcriptional repressor, was postulated to regulate the metabolism of the Amadori compound fructose-asparagine (F-Asn) in the foodborne pathogen Salmonella enterica. Here, the DNA- and inducer-binding affinities and stoichiometries of FraR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6804c93cc3d91b0ca3e1379b3d9a0a5d
https://europepmc.org/articles/PMC8977229/

Würzburg

Autor: David M. Behrman, Edward J. Behrman

Publikováno v: Emil Fischer’s ‘’From My Life’’ ISBN: 9783031051555

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9686789418f0099751ab20a70f81f435
https://doi.org/10.1007/978-3-031-05156-2_7