Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Edward J. Basom"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The importance of conformational dynamics to protein function is now well-appreciated. An outstanding question is whether they are involved in the effector role played by putidaredoxin (Pdx) in its reduction of the O2 complex of cytochrome P450cam (P
Externí odkaz:
https://doaj.org/article/0a6529b4f9b545629f389ce1dbcf3340
Publikováno v:
Biochemistry. 56:3248-3256
The broad and variable substrate specificity of cytochrome P450 enzymes makes them a model system for studying the determinants of protein molecular recognition. The archetypal cytochrome P450cam (P450cam) is a relatively specific P450, a feature onc
Publikováno v:
Analytical Chemistry. 88:6598-6606
Conformational changes are central to protein function but challenging to characterize with both high spatial and temporal precision. The inherently fast time scale and small chromophores of infrared (IR) spectroscopy are well-suited for characteriza
Publikováno v:
Proceedings of the 73rd International Symposium on Molecular Spectroscopy.
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 5 (2018)
Frontiers in Molecular Biosciences, Vol 5 (2018)
The importance of conformational dynamics to protein function is now well-appreciated. An outstanding question is whether they are involved in the effector role played by putidaredoxin (Pdx) in its reduction of the O2 complex of cytochrome P450cam (P
Publikováno v:
Analytical Methods. 7:7234-7241
Local heterogeneity of microenvironments in proteins is important in biological function, but difficult to characterize experimentally. One approach is the combination of infrared (IR) spectroscopy and site-selective incorporation of probe moieties w
Publikováno v:
Journal of the American Chemical Society. 138(4)
Conformational heterogeneity and dynamics are increasingly evoked in models of protein molecular recognition but are challenging to experimentally characterize. Here we combine the inherent temporal resolution of infrared (IR) spectroscopy with the s
Publikováno v:
The journal of physical chemistry. B. 119(22)
Conformational heterogeneity and dynamics likely contribute to the remarkable activity of enzymes but are challenging to characterize experimentally. These features are of particular interest within the cytochrome P450 class of monooxygenases, which
Publikováno v:
Proceedings of the 69th International Symposium on Molecular Spectroscopy.