Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase

Autor: Nigel C. Brissett, Maria J. Martin, Edward J. Bartlett, Julie Bianchi, Luis Blanco, Aidan J. Doherty

Publikováno v: Cell Reports, Vol 5, Iss 4, Pp 1108-1120 (2013)

Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways. The mechanisms by which breaks are competently brought together and extended during NHEJ is poorly understood. As polymerases extend DNA in a 5′-3�

Externí odkaz: https://doaj.org/article/260dc3972c89470897b61680e0c7e30a

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

Autor: Alex Hunt, Bastien Touquet, Joanna C. Young, Bethan A Wallbank, Edward W. Tate, Moritz Treeck, Isabelle Tardieux, Luis Vigetti, Stephen Matthews, Malgorzata Broncel, Caia Dominicus, Edward J Bartlett, Stefania Federico, Stephanie D. Nofal

Publikováno v: eLife, Vol 9 (2020)
Broncel, M, Dominicus, C, Vigetti, L, Nofal, S D, Bartlett, E J, Touquet, B, Hunt, A, Wallbank, B A, Federico, S, Matthews, S, Young, J C, Tate, E W, Tardieux, I & Treeck, M 2020, ' Profiling of myristoylation in toxoplasma gondii reveals an n-myristoylated protein important for host cell penetration ', eLIFE, vol. 9, e57861, pp. 1-38 . https://doi.org/10.7554/eLife.57861

N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Myristoylation often primes for subsequent palmitoylation and stable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c56a9d45a68a820fc33afaa5fd3936e
https://doi.org/10.7554/elife.57861

Molecular basis for DNA strand displacement by NHEJ repair polymerases

Autor: Edward J, Bartlett, Nigel C, Brissett, Przemyslaw, Plocinski, Tom, Carlberg, Aidan J, Doherty

Publikováno v: Nucleic Acids Research

The non-homologous end-joining (NHEJ) pathway repairs DNA double-strand breaks (DSBs) in all domains of life. Archaea and bacteria utilize a conserved set of multifunctional proteins in a pathway termed Archaeo-Prokaryotic (AP) NHEJ that facilitates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a081534a2ec1c529ea59c31bfeb6410c
https://pubmed.ncbi.nlm.nih.gov/26405198

Nonhomologous End Joining in Bacteria

Autor: Edward J. Bartlett, Aidan J. Doherty

DNA can be so severely damaged that both strands of the duplex are broken to produce double-strand breaks (DSBs). Bacterial cells, like mammalian cells, can survive this potentially lethal form of damage by using specialized repair proteins to mend t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f22fff50a1fcd74ca2c8cab8c36d9dc
https://doi.org/10.1016/b978-0-12-378630-2.00407-2

"A Rare Phenomenon of Philological Vegetation": The Word "Contraband" and the Meanings of Emancipation in the United States.

Autor: Masur, Kate¹

Publikováno v: Journal of American History. Mar2007, Vol. 93 Issue 4, p1050-1084. 35p. 10 Black and White Photographs.