Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Edward J. A. Douglas"'
Publikováno v:
Microbial Biotechnology, Vol 16, Iss 7, Pp 1456-1474 (2023)
Abstract Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and currently represents one of the most significant threats to global health. Staphylococcus aureus remains a formidable human pathogen with high mortalit
Externí odkaz:
https://doaj.org/article/bd367d079a2a4da5aa3dd2ad3c002d4a
Autor:
Edward J. A. Douglas, Abdulaziz H. Alkhzem, Toska Wonfor, Shuxian Li, Timothy J. Woodman, Ian S. Blagbrough, Maisem Laabei
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
New therapeutic options are urgently required for the treatment of Staphylococcus aureus infections. Accordingly, we sought to exploit the vulnerability of S. aureus to naturally occurring polyamines. We have developed and tested the anti-staphylococ
Externí odkaz:
https://doaj.org/article/7c30206c98824363bb8158df33d48de4
Publikováno v:
Microbiology
Understanding the role specific bacterial factors play in the development of severe disease in humans is critical if new approaches to tackle such infections are to be developed. In this study we focus on genes we have found to be associated with pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5307cc1e83d66832b12231fc5379eda
https://pubmed.ncbi.nlm.nih.gov/34618666
https://pubmed.ncbi.nlm.nih.gov/34618666
Publikováno v:
Microbiology. 167
Understanding the role specific bacterial factors play in the development of severe disease in humans is critical if new approaches to tackle such infections are to be developed. In this study we focus on genes we have found to be associated with pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d807e3f681ceb3b2cb393c1d8aca0d
https://doi.org/10.1099/mic.0.001096
https://doi.org/10.1099/mic.0.001096
Autor:
Mario Recker, Eóin C O'Brien, Ruth C. Massey, Rachel M. McLoughlin, Tarcisio Brignoli, Edward J. A. Douglas
Introductory ParagraphFor opportunistic pathogens, the switch from a commensal to an invasive lifestyle is often considered an accidental event. But with plentiful opportunity, what leads one accidental event to result in an invasive infection, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c031cb98e8d7547a3817f26daeaca3
https://doi.org/10.1101/2021.07.19.452914
https://doi.org/10.1101/2021.07.19.452914
Publikováno v:
Antimicrob Agents Chemother
Serine β-lactamases are dominant causes of β-lactam resistance in Klebsiella pneumoniae isolates. Recently, this has driven clinical deployment of the β-lactam–β-lactamase inhibitor pairs ceftazidime/avibactam and meropenem/vaborbactam. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4d6cbd91be7e9ce2f16c7085b08c22
https://doi.org/10.1128/aac.00409-20
https://doi.org/10.1128/aac.00409-20
Serine cephalosporinases and carbapenemases are dominant causes of critically important β-lactam resistance in Klebsiella pneumoniae. This has led to the recent clinical deployment of new serine β-lactamase inhibitors used in combination with β-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe91d0f4de95b46d90b7b80274103cab
Autor:
Punyawee, Dulyayangkul, Wan Ahmad Kamil, Wan Nur Ismah, Edward J A, Douglas, Matthew B, Avison
Publikováno v:
Antimicrob Agents Chemother
Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::755f419e6a719d4d83f08cfef8a5ebd8
https://pubmed.ncbi.nlm.nih.gov/32312773
https://pubmed.ncbi.nlm.nih.gov/32312773