Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Edward J Vigmond"'
Autor:
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J Vigmond, Pablo Lamata, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010196 (2022)
[This corrects the article DOI: 10.1371/journal.pcbi.1008851.].
Externí odkaz:
https://doaj.org/article/6409a5cec0d8491d81c8d39895020613
Autor:
Yingjing Feng, Caroline H Roney, Jason D Bayer, Steven A Niederer, Mélèze Hocini, Edward J Vigmond
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009893 (2022)
Focal sources (FS) are believed to be important triggers and a perpetuation mechanism for paroxysmal atrial fibrillation (AF). Detecting FS and determining AF sustainability in atrial tissue can help guide ablation targeting. We hypothesized that sus
Externí odkaz:
https://doaj.org/article/407cb79ab3844105882dd510dda696b8
Autor:
Namit Gaur, Xiao-Yan Qi, David Benoist, Olivier Bernus, Ruben Coronel, Stanley Nattel, Edward J Vigmond
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009137 (2021)
The pig is commonly used as an experimental model of human heart disease, including for the study of mechanisms of arrhythmia. However, there exist differences between human and porcine cellular electrophysiology: The pig action potential (AP) has a
Externí odkaz:
https://doaj.org/article/9831a5a1990a4379bc682430a8199d1d
Autor:
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J Vigmond, Pablo Lamata, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008851 (2021)
Cardiac anatomy plays a crucial role in determining cardiac function. However, there is a poor understanding of how specific and localised anatomical changes affect different cardiac functional outputs. In this work, we test the hypothesis that in a
Externí odkaz:
https://doaj.org/article/2d7ba169e8be4c0eb71d0d60f5b652c3
Autor:
Marina Strocchi, Christoph M Augustin, Matthias A F Gsell, Elias Karabelas, Aurel Neic, Karli Gillette, Orod Razeghi, Anton J Prassl, Edward J Vigmond, Jonathan M Behar, Justin Gould, Baldeep Sidhu, Christopher A Rinaldi, Martin J Bishop, Gernot Plank, Steven A Niederer
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235145 (2020)
Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in si
Externí odkaz:
https://doaj.org/article/a532251ad151443eaa2782b891eefba8
Autor:
Caroline H Roney, Jason D Bayer, Hubert Cochet, Marianna Meo, Rémi Dubois, Pierre Jaïs, Edward J Vigmond
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 5, p e1006166 (2018)
Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to
Externí odkaz:
https://doaj.org/article/a728a66082394b07a9d162d1385f814c
Autor:
Jie Liu, Jason D Bayer, Roozbeh Aschar-Sobbi, Marianne Wauchop, Danna Spears, Michael Gollob, Edward J Vigmond, Robert Tsushima, Peter H Backx, Vijay S Chauhan
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197273 (2018)
BACKGROUND:The SCN5A mutation, P1332L, is linked to a malignant form of congenital long QT syndrome, type 3 (LQT3), and affected patients are highly responsive to the Na+ channel blocking drug, mexiletine. In contrast, A647D is an atypical SCN5A muta
Externí odkaz:
https://doaj.org/article/7a2d35b559e2465bbf94205a78d6d567
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107984 (2014)
Fitting parameter sets of non-linear equations in cardiac single cell ionic models to reproduce experimental behavior is a time consuming process. The standard procedure is to adjust maximum channel conductances in ionic models to reproduce action po
Externí odkaz:
https://doaj.org/article/410f05fd9dcb494b82655b13d40ae601
Autor:
Patrick M Boyle, Carolyn J Park, Hermenegild J Arevalo, Edward J Vigmond, Natalia A Trayanova
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86947 (2014)
Organ-scale arrhythmogenic consequences of source-sink mismatch caused by impaired excitability remain unknown, hindering the understanding of pathophysiology in disease states like Brugada syndrome and ischemia.We sought to determine whether sodium
Externí odkaz:
https://doaj.org/article/cd668bb0634041ec807bf22b8bdf0dea
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88000 (2014)
The Purkinje system is the fast conduction network of the heart which couples to the myocardium at discrete sites called Purkinje-Myocyte Junctions (PMJs). However, the distribution and number of PMJs remains elusive, as does whether a particular PMJ
Externí odkaz:
https://doaj.org/article/cbe307b662fa41be8bdbcf99e8bc9fc8