Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Edward J, Wild"'
Autor:
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials. Sensiti
Externí odkaz:
https://doaj.org/article/89b2e043ae1a4ef094cfbb9512ed2741
Autor:
Annett Boeddrich, Christian Haenig, Nancy Neuendorf, Eric Blanc, Andranik Ivanov, Marieluise Kirchner, Philipp Schleumann, Irem Bayraktaroğlu, Matthias Richter, Christine Mirjam Molenda, Anje Sporbert, Martina Zenkner, Sigrid Schnoegl, Christin Suenkel, Luisa-Sophie Schneider, Agnieszka Rybak-Wolf, Bianca Kochnowsky, Lauren M. Byrne, Edward J. Wild, Jørgen E. Nielsen, Gunnar Dittmar, Oliver Peters, Dieter Beule, Erich E. Wanker
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-32 (2023)
Abstract Background Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely u
Externí odkaz:
https://doaj.org/article/84f66523eef540e7aa35e8b03a0fbf0e
Autor:
Yara Refaat Hassan, Filipe Brogueira Rodrigues, Paul Zeun, Lauren M. Byrne, Carlos Estevez-Fraga, Rosanna Tortelli, Rachael I. Scahill, Edward J. Wild, Sarah J. Tabrizi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Lumbar puncture (LP) has become increasingly common for people with Huntington’s disease (HD) both to administer intrathecal investigational medicinal products and to collect cerebrospinal fluid to develop biological markers to track disea
Externí odkaz:
https://doaj.org/article/ad4a5e730417443781456cf2e0327ad6
Autor:
Florian Lipsmeier, Cedric Simillion, Atieh Bamdadian, Rosanna Tortelli, Lauren M Byrne, Yan-Ping Zhang, Detlef Wolf, Anne V Smith, Christian Czech, Christian Gossens, Patrick Weydt, Scott A Schobel, Filipe B Rodrigues, Edward J Wild, Michael Lindemann
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 6, p e32997 (2022)
BackgroundRemote monitoring of Huntington disease (HD) signs and symptoms using digital technologies may enhance early clinical diagnosis and tracking of disease progression, guide treatment decisions, and monitor response to disease-modifying agents
Externí odkaz:
https://doaj.org/article/be7ef03add614a4cbbff46610a18dd00
Autor:
Zhen-Yi Andy Ou, Lauren M. Byrne, Filipe B. Rodrigues, Rosanna Tortelli, Eileanoir B. Johnson, Martha S. Foiani, Marzena Arridge, Enrico De Vita, Rachael I. Scahill, Amanda Heslegrave, Henrik Zetterberg, Edward J. Wild
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF function is reduced in Huntington’s disease (HD), possibly because mutant huntingtin impairs its cortico-striatal transport, contributing to s
Externí odkaz:
https://doaj.org/article/87c1ce7916eb411a90ed61e22ac22bba
Publikováno v:
Journal of Huntington's Disease. 11:351-367
In this edition of the Huntington’s Disease Clinical Trials Corner, we expand on the PIVOT HD (PTC518), and SIGNAL (pepinemab) trials, and list all currently registered and ongoing clinical trials in Huntington’s disease. We also introduce a ‘b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323ef2031bd47e005dc000ae5a26c213
https://doi.org/10.3233/jhd-229006
https://doi.org/10.3233/jhd-229006
Autor:
Alexander J Lowe, Simon Sjödin, Filipe B Rodrigues, Lauren M Byrne, Kaj Blennow, Rosanna Tortelli, Henrik Zetterberg, Edward J Wild
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0233820 (2020)
Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo. The endo-lysosomal/autophagy system is dysfunctional in HD, potentially contributing to disease
Externí odkaz:
https://doaj.org/article/abadd71913544f01ab9800c20c4666ba
Publikováno v:
Journal of Huntington's Disease. 11:105-118
In this edition of the Huntington’s Disease Clinical Trials Corner we expand on GENERATION HD1, PRECISION-HD1 and PRECISION-HD2, SELECT-HD, and VIBRANT-HD trials, and list all currently registered and ongoing clinical trials in Huntington’s disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b048fb5ec80961f3a969bf0094e475
https://doi.org/10.3233/jhd-229002
https://doi.org/10.3233/jhd-229002
Autor:
Tamara Maiuri, Carlos Barba Bazan, Rachel J. Harding, Nola Begeja, Tae-In Kam, Lauren M. Byrne, Filipe B. Rodrigues, Monica M. Warner, Kaitlyn Neuman, Muqtasid Mansoor, Mohsen Badiee, Morgan Dasovich, Anthony K. L. Leung, Sara N. Andres, Edward J. Wild, Ted M. Dawson, Valina L. Dawson, Cheryl H. Arrowsmith, Ray Truant
Huntington’s disease (HD) is an autosomal dominant genetic neurodegenerative disease caused by a CAG expansion in theHuntingtin (HTT)gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset is corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1310ffef06654ba9e95bead255cc3210
https://doi.org/10.1101/2022.11.23.517669
https://doi.org/10.1101/2022.11.23.517669
Autor:
Lauren M Byrne, Jordan L Schultz, Sophie Field, Kate Fayer, Yara Hassan, Filipe B Rodrigues, Ellen van der Plas, Douglas Langbehn, Sarah J Tabrizi, Peggy C Nopoulos, Edward J Wild
Publikováno v:
D: Wet biomarkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a623614cb6cf452e967cc6e00b8c454d
https://doi.org/10.1136/jnnp-2022-ehdn.62
https://doi.org/10.1136/jnnp-2022-ehdn.62