Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Autor: Sonia Chothani, Leroy S. Pakkiri, Robert George Edward Holgate, Stuart A. Cook, Anissa A. Widjaja, Leanne E. Felkin, Joyce Sze Yuin Goh, Jin Zhou, Jessie Tan, Shamini Guna Shekeran, Brijesh K. Singh, James W. Dear, Chester L. Drum, Paul M. Yen, Mao Wang, Arron Hearn, Sivakumar Viswanathan, Eleonora Adami, Jinrui Dong, Benjamin K Ng, Sze Yun Lim, Sebastian Schafer, W. Lim

Publikováno v: Widjaja, A A, Dong, J, Adami, E, Viswanathan, S, Ng, B K, Pakkiri, L S, Chothani, S P, Singh, B K, Lim, W W, Zhou, J, Shekeran, S G, Tan, J, Lim, S Y, Goh, J, Wang, M, Holgate, R, Hearn, A, Felkin, L E, Yen, P M, Dear, J W, Drum, C L, Schafer, S & Cook, S A 2021, ' Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury ', Science Translational Medicine . https://doi.org/10.1126/scitranslmed.aba8146

Acetaminophen (N-acetyl-p-aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9637aaa604b680452bf1c8c6b7f9c92
https://hdl.handle.net/20.500.11820/df15ad75-899e-473e-b005-40028e26382b

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses

Autor: S Purohit, K Lasseter, Amit Gandhi, Derry C. Roopenian, Robert George Edward Holgate, Jonathan J. Hubbard, J E Humphries, L E Stolz, Jan Terje Andersen, Michal Pyzik, Atiya Mahmood, D de Graaf, Susan D. Jones, Arron Hearn, Alan J. Bitonti, J S Graydon, Richard S. Blumberg, K Kacena, Laurence J. Blumberg, Gregory J. Christianson, B Del Tito, L B Pearce, J. Cheung

Publikováno v: Science Advances

Therapeutic blockade of FcRn in humans decreases IgG and IgG immune complex levels with the attendant immunologic implications.
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7956be3e71940724cce8ce3634ea7a40
http://hdl.handle.net/10852/76135

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4+ T cell epitopes and its use as an immunotoxin warhead

Autor: Tim Jones, Matthew P. Baker, Francis J. Carr, Mark H. Fogg, Robert George Edward Holgate, Arron Hearn, Javier Lacadena, Kurt R. Gehlsen, Dorota Kozub

Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Protein Engineering, Design and Selection
E-Prints Complutense. Archivo Institucional de la UCM
instname

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209fe0a1eed852bfde9eaf83aad40f8f

Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy and Reduced Immunogenicity

Autor: Robert George Edward Holgate, Tim Jones, Richard Weldon, Matthew P. Baker

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138123 (2015)
PLoS ONE

Anti-CD52 therapy has been shown to be effective in the treatment of a number of B cell malignancies, hematopoietic disorders and autoimmune diseases (including rheumatoid arthritis and multiple sclerosis); however the current standard of treatment,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68379a4943f1759f9b60dfe8dc0a6ab3
http://europepmc.org/articles/PMC4570798?pdf=render