Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Edward Hitti"'
Autor:
Qamraa H. Al‐Qahtani, Walid N. Moghrabi, Suhad Al‐Yahya, Latifa Al‐Haj, Maher Al‐Saif, Linah Mahmoud, Falah Al‐Mohanna, Norah Al‐Souhibani, Ayodele Alaiya, Edward Hitti, Khalid S. A. Khabar
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)
Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE).
Externí odkaz:
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Overall list the over-expressed ARE-mRNAs in breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ccd07a744646eb0ff8c95a819165fc
https://doi.org/10.1158/0008-5472.22412201
https://doi.org/10.1158/0008-5472.22412201
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Defects in AU-rich elements (ARE)-mediated posttranscriptional control can lead to several abnormal processes that underlie carcinogenesis. Here, we performed a systematic analysis of ARE-mRNA expression across multiple cancer types. First, the ARE d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3758d6f1d8fd764eec01a63f69178e40
https://doi.org/10.1158/0008-5472.c.6508388.v1
https://doi.org/10.1158/0008-5472.c.6508388.v1
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Supplemental methods on statistical correlation modeling, RNA-IP, and Taqman assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588b9c1555826e077b1fc51ec4f6861f
https://doi.org/10.1158/0008-5472.22412210
https://doi.org/10.1158/0008-5472.22412210
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Correlation data of the mRNA levels for TTP, HuR, TTP/HuR ratio with ARE- and non-ARE mRNA expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283688b3c9ecc580eca972d6f1b4cafb
https://doi.org/10.1158/0008-5472.22412198.v1
https://doi.org/10.1158/0008-5472.22412198.v1
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Reporter sequences containing the putative AREs and their AU context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a342211ab840e2cf9c133e3dd78e5110
https://doi.org/10.1158/0008-5472.22412195
https://doi.org/10.1158/0008-5472.22412195
Autor:
Ayodele Alaiya, Norah Al-Souhibani, Latifa Al-Haj, Qamraa H. Al‐Qahtani, Falah Al-Mohanna, Edward Hitti, Suhad Al-Yahya, Walid Moghrabi, Maher Al-Saif, Khalid S.A. Khabar, Linah Mahmoud
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)
Molecular Oncology
Molecular Oncology
Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db036870787f3266b37aae25edb28f2
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
Publikováno v:
RNA Biology
AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3ʹUTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c8110d5ac98f56435c9c734cb59fe
https://doi.org/10.1080/15476286.2019.1572437
https://doi.org/10.1080/15476286.2019.1572437
Autor:
Sulaiman Altwijri, Linah Mahmoud, Shaima Kutbi, Alaa S. Abdulkarim, Khalid S.A. Khabar, Walid Moghrabi, Edward Hitti
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Frontiers in Immunology
Cyclic-di-AMP (c-di-AMP) is a bacterial second messenger that is produced by intracellular bacterial pathogens in mammalian host macrophages. Previous reports have shown that c-di-AMP is recognized by intracellular pattern recognition receptors of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49831e8c2879ee874c3a02fddfbfe790
https://doi.org/10.3389/fimmu.2019.03050
https://doi.org/10.3389/fimmu.2019.03050
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:167-177
Adenylate-uridylate (AU)-rich elements (AREs) are sequence instability elements that are known to be located in the 3' untranslated regions (UTR) in thousands of human transcripts. AREs regulate the expression of many genes at the post-transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f3821905a5600b31a52a583ff0e793
https://doi.org/10.1016/j.bbagrm.2017.12.006
https://doi.org/10.1016/j.bbagrm.2017.12.006