Výsledky vyhledávání - "Edward Hincliffe"

CCRG-02. THE DIFFUSE MIDLINE GLIOMA MUTATIONS, H3.3 K27M AND G34R/V, INHIBIT MITOTIC PHOSPHORYLATION OF SERINE 31, LEADING TO TUMOR FORMATION THROUGH INCREASED CHROMOSOMAL INSTABILITY

Autor: Charles Day, Florina Grigore, Alyssa Langfald, Faruck Hakkim, David Daniels, Kevin Vaughan, James Robinson, Edward Hincliffe

Publikováno v: Neuro-Oncology. 24:vii37-vii38

Diffuse midline gliomas (DMG) are high-grade pediatric gliomas that frequently harbor heterozygous histone H3.3 K27M, G34R, or G34V mutations. These mutations alter histone methylations, although the precise mechanism(s) of gliomagenesis remains unce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05d821ade51e299fd7e235b86b86b9a6
https://doi.org/10.1093/neuonc/noac209.147

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CSIG-15. DEFINING THE ROLE OF HISTONE H3 K27 METHYLATION AND H3.3 S31 PHOSPHORYLATION IN H3.3K27M MUTANT DIFFUSE MIDLINE GLIOMAS

Autor: Faruck Hakkim, Charles Day, Florina Grigore, Alyssa Langfald, Igor Entin, Edward Hincliffe, James Robinson

Publikováno v: Neuro-Oncology. 24:vii42-vii42

Diffuse midline gliomas (DMG) are aggressive high-grade gliomas that characteristically occurs in children. Heterozygous K27M mutation occurs in histone H3.3 as early events in DMG and are sufficient to drive a global reduction of H3K27 methylation (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dab49fca4082a4408dbdcf998d240359
https://doi.org/10.1093/neuonc/noac209.164

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