Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Edward Hammond"'
Autor:
Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Pixatimod is a unique activator of the Toll-like Receptor 9 pathway. This phase I trial evaluated safety, efficacy and pharmacodynamics of pixatimod and PD-1 inhibitor nivolumab in immunologically cold cancers.Methods 3+3 dose escalation w
Externí odkaz:
https://doaj.org/article/9084358ebd5841eb853afac834f15155
Autor:
Zachariah P. Schuurs, Edward Hammond, Stefano Elli, Timothy R. Rudd, Courtney J. Mycroft-West, Marcelo A. Lima, Mark A. Skidmore, Richard Karlsson, Yen-Hsi Chen, Ieva Bagdonaite, Zhang Yang, Yassir A. Ahmed, Derek J. Richard, Jeremy Turnbull, Vito Ferro, Deirdre R. Coombe, Neha S. Gandhi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2806-2818 (2021)
SARS-CoV-2 has rapidly spread throughout the world’s population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiotensin-converting enzyme-2
Externí odkaz:
https://doaj.org/article/a6e1525cac0a4242ade18498d4c8849d
Autor:
Jean-Philippe Lacour, Anthony Bewley, Edward Hammond, Jes B. Hansen, Laura Horne, Carle Paul, Kristian Reich, Julien Seneschal, Clara De Simone, Anne Sohrt, Matthias Augustin, Giovanni Pellacani
Publikováno v:
Dermatology and Therapy, Vol 10, Iss 5, Pp 1099-1109 (2020)
Abstract Introduction Clinical trials have shown that psoriasis patients who achieve complete skin clearance are more likely to report no impairment in health-related quality of life (HRQoL) and no psoriasis symptoms versus patients who achieve almos
Externí odkaz:
https://doaj.org/article/b80a78872dd94a85b046ef5c90307086
Autor:
Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Michael Brown, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Amanda Stanley, Lucie Leveque-ElMouttie, Grace Chojnowski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/707ab3742ab34661a168c0e1852c01c0
Autor:
Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Michael Brown, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Nigel Waterhouse, Amanda Stanley, Lucie Leveque-ElMouttie, Grace Chojnowski, Andrew Clouson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/28156c09a15e41f3a51704b1a003571b
Autor:
Edward Hammond, Nicole M. Haynes, Carleen Cullinane, Todd V. Brennan, Darryn Bampton, Paul Handley, Tomislav Karoli, Fleur Lanksheer, Liwen Lin, Yiping Yang, Keith Dredge
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Pixatimod (PG545) is a novel clinical-stage immunomodulatory agent capable of inhibiting the infiltration of tumor-associated macrophages (TAMs) yet also stimulate dendritic cells (DCs), leading to activation of natural killer (NK
Externí odkaz:
https://doaj.org/article/106a8f435d52440dbe798c490d689297
Autor:
Iyad Khamaysi, Preeti Singh, Susan Nasser, Hoda Awad, Yehuda Chowers, Edmond Sabo, Edward Hammond, Ian Gralnek, Irena Minkov, Alessandro Noseda, Neta Ilan, Israel Vlodavsky, Zaid Abassi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Acute pancreatitis (AP) is one of the most common diseases in gastroenterology. However, neither the etiology nor the pathophysiology of the disease is fully understood and no specific or effective treatment has been developed. Heparanase is
Externí odkaz:
https://doaj.org/article/eca65dac708643488e8a2f4fe63bd617
Autor:
Preeti Singh, Alexandra Blatt, Sari Feld, Yaniv Zohar, Esraa Saadi, Liza Barki-Harrington, Edward Hammond, Neta Ilan, Israel Vlodavsky, Yehuda Chowers, Elizabeth Half
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 3, Pp 175-184 (2017)
Heparanase activity is highly implicated in cellular invasion and tumor metastasis, a consequence of cleavage of heparan sulfate and remodeling of the extracellular matrix underlying epithelial and endothelial cells. Heparanase expression is rare in
Externí odkaz:
https://doaj.org/article/01c9c72348264fe29058cd8e753769d2
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52175 (2012)
PG545 is a clinically relevant heparan sulfate (HS) mimetic which, in addition to possessing anti-angiogenic properties, also acts as a heparanase inhibitor which may differentiate its mechanism(s) of action from approved angiogenesis inhibitors. The
Externí odkaz:
https://doaj.org/article/6fd74387a1e742fa9a8c0e067f85b4c5
Autor:
Karin Forsberg-Nilsson, Israel Vlodavsky, Uri Barash, Edward Hammond, Keith Dredge, Tommie Olofsson, Di Yu, Lulu Haseeb, Soumi Kundu, Argyris Spyrou
PG545 does not pass the blood-brain barrier (BBB), reduces flank tumor weight in mice, and causes no weight loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813016726d40ac61fb9a87d063fe3b24
https://doi.org/10.1158/1535-7163.22507740.v1
https://doi.org/10.1158/1535-7163.22507740.v1