Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Edward H. Liao"'
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1774-1786.e4 (2019)
Summary: Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2 in DA neurons. Transgenic knockd
Externí odkaz:
https://doaj.org/article/151996a4837f4ca9b1958407794bafa2
Autor:
Jay Penney, Kazuya Tsurudome, Edward H. Liao, Grant Kauwe, Lindsay Gray, Akiko Yanagiya, Mario R. Calderon, Nahum Sonenberg, A. Pejmun Haghighi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic c
Externí odkaz:
https://doaj.org/article/28b871da68c441029f3092bf68c4f2c8
Neuronal response to nutrient availability plays an important role in the maintenance of cellular homeostasis and behavioral response to the environment in higher eukaryotes. However, we know little about how neuronal function is influenced by acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5e20f19bd8d67bbcee04ed9c4ad702
https://doi.org/10.1101/2022.11.03.515133
https://doi.org/10.1101/2022.11.03.515133
Publikováno v:
Cell reports
Cell Reports, Vol 26, Iss 7, Pp 1774-1786.e4 (2019)
Cell Reports, Vol 26, Iss 7, Pp 1774-1786.e4 (2019)
SUMMARY Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2 in DA neurons. Transgenic knockdo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acaabd22937290f1ad1fedea514f93f
http://europepmc.org/articles/PMC6474846
http://europepmc.org/articles/PMC6474846
Autor:
Christian Stigloher, Mei Zhen, Hang Li, Jean-Louis Bessereau, Christine Hwang, Shangbang Gao, Edward H. Liao, Jyothsna Chitturi, Ying Wang, Wesley Hung
Publikováno v:
The EMBO Journal. 32:1745-1760
A neuronal F-box protein FSN-1 regulates Caenorhabditis elegans neuromuscular junction development by negatively regulating DLK-mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a571851f209ac52d8614f8d5f49a33
https://doi.org/10.1038/emboj.2013.91
https://doi.org/10.1038/emboj.2013.91
Autor:
Mark Livingstone, Miranda Gonzalez, Edward H. Liao, Nahum Sonenberg, A. Pejmun Haghighi, Jay Penney, Kazuya Tsurudome, Fatima Elazzouzi
Publikováno v:
Neuron. 74(1):166-178
SummaryHomeostatic mechanisms operate to stabilize synaptic function; however, we know little about how they are regulated. Exploiting Drosophila genetics, we have uncovered a critical role for the target of rapamycin (TOR) in the regulation of synap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75998924ce705d90f66c3aba6efd4986
Autor:
Wassim El-Mounzer, Mario R. Calderon, Sarah Farzin, Grant Kauwe, Fatima Elazzouzi, Edward H. Liao, Christopher Baim, Lindsay Gray, Kazuya Tsurudome, A. Pejmun Haghighi
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 1, p e1007184 (2018)
PLoS Genetics, Vol 14, Iss 1, p e1007184 (2018)
Retrograde signaling is essential for neuronal growth, function and survival; however, we know little about how signaling endosomes might be directed from synaptic terminals onto retrograde axonal pathways. We have identified Khc-73, a plus-end direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd59d7d5e570fd038f671efed1032a6
https://doi.org/10.1371/journal.pgen.1007184
https://doi.org/10.1371/journal.pgen.1007184
ITSN-1 Controls Vesicle Recycling at the Neuromuscular Junction and Functions in Parallel with DAB-1
Autor:
Wei Wang, Keli Xu, Xiaofeng Xin, Ameet S. Sengar, Edward H. Liao, John C. Roder, Magali Bouhours, Mei Zhen, Sean E. Egan, Elena O. Gracheva, Janet E. Richmond, Charles Boone
Publikováno v:
Traffic. 9:742-754
Intersectins (Itsn) are conserved EH and SH3 domain containing adaptor proteins. In Drosophila melanogaster, ITSN is required to regulate synaptic morphology, to facilitate efficient synaptic vesicle recycling and for viability. Here, we report our g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5376ac5afbf32ba020bdcf31ba309f30
https://doi.org/10.1111/j.1600-0854.2008.00712.x
https://doi.org/10.1111/j.1600-0854.2008.00712.x
Autor:
Akiko Yanagiya, Mario R. Calderon, Edward H. Liao, Nahum Sonenberg, Lindsay Gray, Grant Kauwe, A. Pejmun Haghighi, Kazuya Tsurudome, Jay Penney
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Parkinson's disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little about its potential role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f4f9f879d809510587f9255a8c1bff
https://pubmed.ncbi.nlm.nih.gov/27432119
https://pubmed.ncbi.nlm.nih.gov/27432119
Publikováno v:
Nature. 430:345-350
During synapse formation, specialized subcellular structures develop at synaptic junctions in a tightly regulated fashion. Cross-signalling initiated by ephrins, Wnts and transforming growth factor-beta family members between presynaptic and postsyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02687c0bc374e5000d3ec3cbd4f637d4
https://doi.org/10.1038/nature02647
https://doi.org/10.1038/nature02647