Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Edward G. McIver"'
Autor:
Alice C Newman, Caroline L Scholefield, Alain J Kemp, Michelle Newman, Edward G McIver, Ahmad Kamal, Simon Wilkinson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50672 (2012)
K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, cons
Externí odkaz:
https://doaj.org/article/98c61e704c564ad7bd714b425a344b0d
Autor:
Dario R. Alessi, Kristian Birchall, Ela Smiljanic-Hurley, Alison Levy, Edward G. McIver, Denise J. Tsagris, Joanne Osborne, Stephen John Lewis, Debra L. Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(4)
Parkinson's disease is a relatively common neurological disorder with incidence increasing with age. Present treatments merely alleviate the symptoms and do not alter the course of the disease, thus identification of disease modifying therapies repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ceb9c04ce3ece4e8597335904def25
https://pubmed.ncbi.nlm.nih.gov/30554956
https://pubmed.ncbi.nlm.nih.gov/30554956
Autor:
Daniel G. Shore, Andrew D. Medhurst, Zachary Kevin Sweeney, Xingrong Liu, Andrew W. Gill, Edward G. McIver, John Moffat, Jason Drummond, Alan Beresford, Bryan K. Chan, Tracy Kleinheinz, Haitao Zhu, Huifen Chen, Anthony A. Estrada
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(4)
The discovery of disease-modifying therapies for Parkinson’s Disease (PD) represents a critical need in neurodegenerative medicine. Genetic mutations in LRRK2 are risk factors for the development of PD, and some of these mutations have been linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037486ba107ae90cb34b8b5dd9f63986
https://pubmed.ncbi.nlm.nih.gov/30522953
https://pubmed.ncbi.nlm.nih.gov/30522953
Autor:
Edward G. McIver, Jeff Jerman, Nicholas Harries, Amanda E. Mackenzie, Graeme Milligan, Craig Southern, Debra L. Taylor, Zaynab Neetoo-Isseljee
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:568-578
Drugs targeting the orphan receptor GPR35 have potential therapeutic application in a number of disease areas, including inflammation, metabolic disorders, nociception, and cardiovascular disease. Currently available surrogate GPR35 agonists identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64acac71a63a98d498f42a5553dc04ad
https://doi.org/10.1124/jpet.112.201798
https://doi.org/10.1124/jpet.112.201798
Autor:
Graeme Milligan, Debra L. Taylor, Edward G. McIver, Craig Southern, Zaynab Neetoo-Isseljee, Laura Jenkins, Amanda E. Mackenzie, Jennifer E. Lappin, Nicholas Harries, Stuart A. Nicklin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:683-695
Variation in pharmacology and function of ligands at species orthologs can be a confounding feature in understanding the biology and role of poorly characterized receptors. Substantial selectivity in potency of a number of GPR35 agonists has previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af97675b7d8fd2646949bb015256f656
https://doi.org/10.1124/jpet.112.198945
https://doi.org/10.1124/jpet.112.198945
Autor:
Edward G. McIver, Peter C. F. Cheung, Christiane Ruedl, Liang Dai, Cheah-Chen Seh, Robert Gourlay, Philip Cohen, Julien Lescar, Simon Morton, Aye-Thu Chan, Insaf A. Qureshi, Eddy T. H. Goh, Joanne Hough, Xin-Yu Liu, Hilary Smith, Jiajia Xi
Publikováno v:
Biochemical Journal. 434:537-548
Mammalian Pellino isoforms are phosphorylated by IRAK (interleukin receptor associated kinase) 1/IRAK4 in vitro, converting them into active E3 ubiquitin ligases. In the present paper we report a striking enhancement in both transcription of the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41060ccc84c99bb056e49d39347f944
https://doi.org/10.1042/bj20101421
https://doi.org/10.1042/bj20101421
Publikováno v:
Tetrahedron. 59:10453-10463
A novel series of modular chiral polyether podands derived from enantiomerically pure hydrobenzoin and binaphthol has been prepared using a NaH/15-crown-5 mediated Williamson ether synthesis. These new homochiral ligands form catalytically active com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ede9ec6301815df185807c6343b715
https://doi.org/10.1016/j.tet.2003.06.008
https://doi.org/10.1016/j.tet.2003.06.008
Autor:
Philip Magnus, Edward G. McIver
Publikováno v:
Tetrahedron Letters. 41:831-834
Chlorination of the bis-oxazole-indole 16 using N -chlorosuccinimide gave the dichloride 13 (86%) and the trichloride 12 (5%) thus completing the synthesis of the CDEF rings of diazonamide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5b491d46e0902ee1f0e976d6742105
https://doi.org/10.1016/s0040-4039(99)02203-0
https://doi.org/10.1016/s0040-4039(99)02203-0
Publikováno v:
Tetrahedron Letters. 41:835-838
The synthesis of 6 comprising the CDG rings of the diazonamides was achieved in an overall yield of 75% from commercially available 3 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c23040261d9f15f874a6fb9527f6df
https://doi.org/10.1016/s0040-4039(99)02204-2
https://doi.org/10.1016/s0040-4039(99)02204-2
Publikováno v:
Tetrahedron Letters. 39:9283-9286
Addition of one equivalent of benzoic acid greatly enhances the efficiency of our ytterbium triflate catalyzed allylation of aldehydes with allyltributyltin in acetonitrile. Crucial modifications to reaction conditions result in a dramatically increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08352cfb4f49abbd943555fadbf9132f
https://doi.org/10.1016/s0040-4039(98)02086-3
https://doi.org/10.1016/s0040-4039(98)02086-3