Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Edward G. Lynn"'
Autor:
Jack Chen, Edward G. Lynn, Tamana R. Yousof, Hitesh Sharma, Melissa E. MacDonald, Jae Hyun Byun, Bobby Shayegan, Richard C. Austin
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1098 (2022)
The 78 kDa glucose-regulated protein (GRP78) is considered an endoplasmic reticulum (ER)-resident molecular chaperone that plays a crucial role in protein folding homeostasis by regulating the unfolded protein response (UPR) and inducing numerous pro
Externí odkaz:
https://doaj.org/article/10bb82b33def45fd8efc7e31c4aef2c9
Autor:
Susanna Hummel, Edward G. Lynn, Andreas Osanger, Satoshi Hirayama, Johannes Nimpf, Wolfgang J. Schneider
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 9, Pp 1633-1642 (2003)
Low levels of expression and sluggish sterol-mediated regulation have been likely reasons for the failure to molecularly characterize a bona fide LDL receptor (LDLR) in egg-laying species to date. The overall structure of the chicken LDLR, delineated
Externí odkaz:
https://doaj.org/article/91ff4f2174b64c4e9f7b0f4a026c5458
Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity
Autor:
Jae Hyun Byun, Paul F. Lebeau, Khrystyna Platko, Rachel E. Carlisle, Mahi Faiyaz, Jack Chen, Melissa E. MacDonald, Yumna Makda, Tamana Yousof, Edward G. Lynn, Jeffrey G. Dickhout, Joan C. Krepinsky, Fiona Weaver, Suleiman A. Igdoura, Nabil G. Seidah, Richard C. Austin
Publikováno v:
Kidney360. 3:1394-1410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3132222269c9da13425d366d322b0000
https://doi.org/10.34067/kid.0007022021
https://doi.org/10.34067/kid.0007022021
Autor:
Richard C. Austin, Khrystyna Platko, Edward R. O'Brien, Šárka Lhoták, Paul F. Lebeau, Jack Chen, Edward G. Lynn, Jae Hyun Byun, Chunhua Shi
Publikováno v:
The FASEB Journal. 33:8406-8422
Endoplasmic reticulum stress plays an important role in cardiovascular disease (CVD) and atherosclerosis. We aimed to assess the ability of 4-phenylbutyrate (4-PBA), a small chemical chaperone administered via drinking water, to reduce atheroscleroti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b97e42565a4ba3dd390095d80708066
https://doi.org/10.1096/fj.201802293rr
https://doi.org/10.1096/fj.201802293rr
Autor:
Victor Tat, Philipp Kolb, Kjetil Ask, Šárka Lhoták, James Murphy, Edward G. Lynn, Mark D. Inman, Zahraa Mohammed-Ali, Ehab A. Ayaub, Chiko Shimbori, Darren Bridgewater, Pierre-Simon Bellaye, Felix J. Boivin, Martin Kolb, Rocky Lai, Richard C. Austin, Jeffrey G. Dickhout
Publikováno v:
The Journal of Pathology. 239:411-425
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been associated with fibrotic lung disease, although exactly how they modulate this process remains unclear. Here we investigated the role of GRP78, the main UPR regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17fbc8ac7b3bab1378821267b5b674b6
https://doi.org/10.1002/path.4738
https://doi.org/10.1002/path.4738
Autor:
Nathan J. Cherrington, Hui Li, Gregory R. Steinberg, Tamana Rubina Yousof, Edward G. Lynn, Kenneth N. Maclean, Sarka Lhotak, Hua Jiang, Mihnea Alb, Richard C. Austin, Celeste Bouchard, Joan C. Krepinsky
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85c3a451fcbfea761630cdd1f70dfb7
https://doi.org/10.1096/fasebj.2018.32.1_supplement.670.30
https://doi.org/10.1096/fasebj.2018.32.1_supplement.670.30
Autor:
Joan C. Krepinsky, Serena Marchiò, Khrystyna Platko, Ali Al-Hashimi, Jack Chen, Jae Hyun Byun, Magda Naeim, Wadih Arap, Richard C. Austin, Katey J. Rayner, Šárka Lhoták, Elizabeth D. Crane, Renata Pasqualini, Edward G. Lynn, Bobby Shayegan, Paul Lebeau, Kevin Doyoon Won
Publikováno v:
JCI insight. 3(24)
The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that cause ER stress can promote the relocalization of GRP78 to the cell surface (csGRP78), where i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2016c74739c36ed103fc9d02010a8a0
https://pubmed.ncbi.nlm.nih.gov/30568038
https://pubmed.ncbi.nlm.nih.gov/30568038
Autor:
Kenneth N. Maclean, Morgan D. Fullerton, Gregory R. Steinberg, Edward G. Lynn, Hua Jiang, Sana Basseri, Rebecca J. Ford, Rengasamy Palanivel, Richard C. Austin, Šárka Lhoták
Publikováno v:
Diabetes
Regulation of energy metabolism is critical for the prevention of obesity, diabetes, and hepatic steatosis. Here, we report an important role for the pleckstrin homology–related domain family member, T-cell death–associated gene 51 (TDAG51), in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb48e56040ab42d78aaa9eac9778b2
https://doi.org/10.2337/db12-0256
https://doi.org/10.2337/db12-0256
Autor:
Edward G. Lynn, Ji Zhou, Šárka Lhoták, Brooke A. Hilditch, Sudesh K. Sood, Alistair J. Ingram, Jeffrey G. Dickhout, Richard C. Austin, Stephen M. Colgan, Rachel E. Carlisle, Sana Basseri
Publikováno v:
The FASEB Journal. 25:576-589
Endoplasmic reticulum (ER) stress causes macrophage cell death within advanced atherosclerotic lesions, thereby contributing to necrotic core formation and increasing the risk of atherothrombotic disease. However, unlike in advanced lesions, the appe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c9c64ff17b7e2c84dd9fdc89910e29
https://doi.org/10.1096/fj.10-159319
https://doi.org/10.1096/fj.10-159319
Autor:
Jeremy Jacobson, Elizabeth Murphy, Mark V. Stevens, Michael N. Sack, Edward G. Lynn, Darin Carabenciov, Renee P. Wong
Publikováno v:
Journal of Molecular and Cellular Cardiology. 49:693-698
Prolonged cardiac overexpression of the mitochondrial biogenesis regulatory transcriptional coactivator PGC-1alpha disrupts cardiac contractile function and its genetic ablation limits cardiac capacity to enhance workload. In contrast, transient indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfed6255edf0ac6e98d534d3e77442b
https://doi.org/10.1016/j.yjmcc.2010.06.008
https://doi.org/10.1016/j.yjmcc.2010.06.008