Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Edward G. Hyde"'
Autor:
Robert F. Deiches, Edward G. Hyde, Virginia M.-Y. Lee, John Q. Trojanowski, Carlo Ballatore, Donna M. Huryn, Amos B. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3642-3646
A series of paclitaxel C-10 carbamates were synthesized and evaluated in a bi-directional permeability assay in comparison with paclitaxel and the blood-brain barrier-permeable C-10 ester derivative, TX-67. A number of the carbamates were found not t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e7998b15ef3a9a543e76ba737a6e63
https://doi.org/10.1016/j.bmcl.2007.04.058
https://doi.org/10.1016/j.bmcl.2007.04.058
Publikováno v:
Biochemical and Biophysical Research Communications. 358:1-6
A library of approximately 51,000 compounds was interrogated by high throughput screening (HTS) using a heparin-induced tau fibrillization assay. HTS was conducted with bacterially expressed recombinant tau fragment K18 and the reaction was monitored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2233604d3fb4120f3306bcd6b6e59c00
https://doi.org/10.1016/j.bbrc.2007.03.056
https://doi.org/10.1016/j.bbrc.2007.03.056
Autor:
Moana Simpson, Ronald J. Quinn, Edward G. Hyde, Malcolm Stewart Buchanan, Annette Edser, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 67:1291-1294
Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd18e8a0f2a81d30448d7ada9bef717d
https://doi.org/10.1021/np049968p
https://doi.org/10.1021/np049968p
Autor:
Naseem Khan, Mohammad S Choudhary, Edward G. Hyde, Richard B. Westkaemper, Edward I Gelbar, Bryan L. Roth, Richard A. Glennon
Publikováno v:
European Journal of Medicinal Chemistry. 34:441-447
Anew binding model for ketanserin was constructed; this model and preliminary mutagenesis data suggested that a highly conserved phenylalanine (F340) introduces a potential region of bulk-intolerance into the binding pocket. We tested this hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4d3c972daadbe55c379425482b4fc5
https://doi.org/10.1016/s0223-5234(99)80094-4
https://doi.org/10.1016/s0223-5234(99)80094-4
Autor:
Leanne Towerzey, Ronald J. Quinn, Mark S. Butler, Edward G. Hyde, Gordon P. Guymer, Ngoc B. Pham, Sao Khemar Wadi
Publikováno v:
Phytochemistry. 98
Extracts from dried leaf and stems of Elaeodendron australe var. integrifolium (Celastraceae) collected in South East Queensland, Australia, were active in an assay that measured Ca 2+ driven expression of IL-2/luciferase designed to identify inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7eb0876f405c82d842a1f79322cb16
https://pubmed.ncbi.nlm.nih.gov/24361289
https://pubmed.ncbi.nlm.nih.gov/24361289
Publikováno v:
Journal of Medicinal Chemistry. 38:4704-4709
The lophotoxins are naturally occurring antagonists of nicotinic acetylcholine receptors. These toxins are small diterpenes that irreversibly inhibit nicotinic receptors by specific covalent modification of Tyr 190 in the α-subunits of the receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1659f3e21fd1e38dd3bb43559a1fe4
https://doi.org/10.1021/jm00023a010
https://doi.org/10.1021/jm00023a010
Autor:
Alex Crowe, Edward G. Hyde, Michael J. James, Virginia M.-Y. Lee, Carlo Ballatore, John Q. Trojanowski, Yuemang Yao, Kurt R. Brunden, Amos B. Smith, Francesco Piscitelli
Agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a544c2a46d6ccaf5729b59d27a33d02a
https://europepmc.org/articles/PMC2872922/
https://europepmc.org/articles/PMC2872922/
Publikováno v:
Biochemistry. 46(44)
Parkinson's disease (PD) is characterized by the accumulation of fibrillar alpha-synuclein (alpha-Syn) inclusions known as Lewy bodies (LBs) and Lewy neurites. Mutations in the alpha-Syn gene or extra copies thereof cause familial PD or dementia with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b920527d9d0a2a8e0fe962c503f31c7
https://pubmed.ncbi.nlm.nih.gov/17927212
https://pubmed.ncbi.nlm.nih.gov/17927212
Autor:
Edward G. Hyde
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 18:917-917
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39085066d650b60cd91aa1c202c70cea
https://doi.org/10.2174/138620731810151103111745
https://doi.org/10.2174/138620731810151103111745
Autor:
Paul I. Forster, Gordon P. Guymer, Edward G. Hyde, Ronald J. Quinn, Anthony R. Carroll, Jill Smith
Publikováno v:
ChemInform. 36
Bioassay-guided fractionation of the aqueous extract of the leaves of Alstonia actinophylla with use of a coupled enzyme assay, CPU/hippuricase, to detect carboxypeptidase U inhibitors led to the isolation of a novel indole alkaloid, actinophyllic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda9f4c5f749dab153cb8871e0a9755f
https://doi.org/10.1002/chin.200526137
https://doi.org/10.1002/chin.200526137