Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Edward F. Elslager"'
Publikováno v:
Journal of medicinal chemistry. 10(3)
Publikováno v:
Journal of Heterocyclic Chemistry. 21:1521-1525
Publikováno v:
Journal of Medicinal Chemistry. 17:75-100
Autor:
Judith L. Johnson, Edward F. Elslager, Leslie M. Werbel, Stephen J. Kesten, Donald F. Worth, Daniel F. Ortwine, Dennis Joseph Mcnamara, Hung Jocelyn H, P. Dan Cook
Publikováno v:
Journal of Medicinal Chemistry. 29:924-939
A series of 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides was prepared from the substituted 1-phenyl-2-propanones proceeding through the 5-nitro[1,1'-biphenyl]-2-ols, the corresponding amino, and ace
Publikováno v:
Journal of Medicinal Chemistry. 24:140-145
N6-(Arylmethyl)-N6-methyl-2,4,6-pteridinetriamines (1-15) and related N6-substituted 2,4,6-pteridinetriamines (16-20) were obtained by the condensation of 6-chloro-2,4-pteridinediamine with N-methylarylmethanamine and other selected secondary amines.
Publikováno v:
Journal of Medicinal Chemistry. 20:1569-1572
5-(2,4,5-Trichlorophenyl)hydantoin and several analogues effected an 80-90% reduction of live schistosomes in infected mice at doses ranging from 265 to 329 mg/kg per day when administered orally in the diet for 14 days. The sodium salt of 5-(2,4,5-t
Publikováno v:
Journal of Heterocyclic Chemistry. 17:129-136
The reaction of 5-chloro-2-nitrobenzonitrile with a variety of mercaptoheterocycles provided the corresponding 2-nitro-5-[(heterocyclic)thio]benzonitriles. Reduction to the amine followed by cyclization with chloroformamidine hydrochloride afforded a
Publikováno v:
Journal of Medicinal Chemistry. 21:331-337
Autor:
Patricia Jacob, Donald F. Worth, Judith L. Johnson, Leslie M. Werbel, Edward F. Elslager, Leo Rane
Publikováno v:
Journal of Medicinal Chemistry. 21:1059-1070
An array of nonclassical thioquinazoline analogues (VIII) of methotrexate was prepared by cyclization of the requisite 2-amino-5-(arylthio)benzonitrile with chloroformamidine hydrochloride (28--79%). The aminonitrile precursors were obtained by SnCl2
Autor:
Edward F. Elslager, Leslie M. Werbel, Leo Rane, Judith L. Johnson, Barbara Temporelli, Donald F. Worth, Marland P. Hutt, Patricia Jacob
Publikováno v:
Journal of Medicinal Chemistry. 22:1247-1257
Oxidation of an array of 2,4-diamino-6-(arylthio)quinazolines provided the corresponding arylsulfinyl and arylsulfonyl analogues. A variety of these nonclassical analogues of methotrexate exhibited suppressive antimalarial activity superior to that o