Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease

Autor: Edward F Griffin, Kim A Caldwell, Guy A Caldwell

Publikováno v: Neural Regeneration Research, Vol 14, Iss 7, Pp 1210-1212 (2019)

Externí odkaz: https://doaj.org/article/99ac54e42ae74695b02d0575f6c1561a

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation

Autor: David Chitayat, Carolina Sepulveda, Tineke Veenendaal, Grace Yoon, Cedric S. Asensio, Henny H. Lemmink, Nalan Liv, Susan Zwakenberg, Andres M. Lozano, Guy A. Caldwell, Edward F Griffin, Fried J. T. Zwartkruis, Rolph Pfundt, Reini E.N. van der Welle, Judith Klumperman, Corlinda ten Brink, Christian H. Burns, Lan Chen, Rebekah Jobling, Paolo Sanza, Susan Blaser, Teresa Santiago-Sim, Alfonso Fasano, Kim A. Caldwell, Jan van der Beek, Conny M. A. van Ravenswaaij-Arts

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
EMBO Molecular Medicine, 13
EMBO Molecular Medicine, 13, 5
EMBO Molecular Medicine, 13(5):13243, 1-24. Wiley
EMBO Molecular Medicine

Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent of HOPS, for regulated secretion. Here, we report three patients with compound heterozygou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a105fc53635f251797810bb00f87610
https://doi.org/10.15252/emmm.202013258

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Autor: Samuel E. Scopel, Edward F Griffin, Cayman Stephen, Kim A. Caldwell, Adam C. Holzhauer, Laura A. Berkowitz, Ryan A. Tuckey, Madeline A Vaji, Guy A. Caldwell

Publikováno v: Disease Models & Mechanisms, Vol 12, Iss 2 (2019)
Disease Models & Mechanisms

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform APOEε2 is associated with reduced risk, while APOEε3 is neutral and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76f41691bd22dad292c7e1997bf335a
http://dmm.biologists.org/content/12/2/dmm037218

Minor Pilins of the Type IV Pilus System Participate in the Negative Regulation of Swarming Motility

Autor: Edward F. Griffin, Sherry L. Kuchma, George A. O'Toole

Publikováno v: Journal of Bacteriology. 194:5388-5403

Pseudomonas aeruginosa exhibits distinct surface-associated behaviors, including biofilm formation, flagellum-mediated swarming motility, and type IV pilus-driven twitching. Here, we report a role for the minor pilins, PilW and PilX, components of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51938227e19f68ed57a2e6d9d4dacd88
https://doi.org/10.1128/jb.00899-12

In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells

Autor: Qianru Yu, Sophie Moreau-Marquis, Joseph D. Schwartzman, Bruce A. Stanton, George A. O'Toole, Edward F. Griffin

Publikováno v: Journal of Antimicrobial Chemotherapy. 67:2673-2681

OBJECTIVES Aztreonam for inhalation solution (AZLI) was recently approved by the FDA for treating cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Here we investigated the effect of aztreonam alone or in combination with tobramycin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7d2d59f8079ae57b0b7445c2156814
https://doi.org/10.1093/jac/dks296