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pro vyhledávání: '"Edward Echevarria"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 44:797-804
The effect of chronic administration of 2(2-dimethylaminoethylthio)-3-phenylquinoline (ICI-169,369) and 2(2-dimethylamino-2-methylpropylthio)- 3-phenylquinoline (ICI-170,809), two selective 5-HT 2 antagonists, on sleep was studied in rats. As previou
Publikováno v:
Life Sciences. 46:PL1-PL7
The pharmacological profile of PD117302 was studied in three rat models of experimental seizures. It was determined that PD117302 is a potent and efficacious anticonvulsant against NMDA (ED50 = 0.27 mg/kg, i.v.) and MES (ED50 = 16.3 mg/kg, s.c.), but
Publikováno v:
Brain research. 485(2)
The effects of the novel, highly selective serotonin-2 (5-HT2) antagonists, ICI 169,369 and ICI 170,809, on 24 h EEG sleep-wake activity were studied in the rat. Both compounds caused a dose-related increase in the latency to rapid eye movement sleep