Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Edward E.S. Nieuwenhuis"'
Autor:
Suze A. Jansen, Alessandro Cutilli, Coco de Koning, Marliek van Hoesel, Cynthia L. Frederiks, Leire Saiz Sierra, Stefan Nierkens, Michal Mokry, Edward E.S. Nieuwenhuis, Alan M. Hanash, Enric Mocholi, Paul J. Coffer, Caroline A. Lindemans
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110072- (2024)
Summary: The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy
Externí odkaz:
https://doaj.org/article/b237740e0ce446bdbb6f4231e7e5bc68
Autor:
Gautam Kok, MD, PhD, Eveline F. Ilcken, MSc, Roderick H.J. Houwen, MD, PhD, Caroline A. Lindemans, MD, PhD, Edward E.S. Nieuwenhuis, MD, PhD, Eric Spierings, PhD, Sabine A. Fuchs, MD, PhD
Publikováno v:
Annals of Surgery Open, Vol 4, Iss 3, p e334 (2023)
Objective:. We aim to investigate the effects of genetically based HLA matching on patient and graft survival, and acute and chronic rejection after liver transplantation Background:. Liver transplantation is a common treatment for patients with end-
Externí odkaz:
https://doaj.org/article/b77e2674970448f99891cba5a9969236
Autor:
Jorik M. van Rijn, Marliek van Hoesel, Cecilia de Heus, Anke H.M. van Vugt, Judith Klumperman, Edward E.S. Nieuwenhuis, Roderick H.J. Houwen, Sabine Middendorp
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100126- (2021)
Externí odkaz:
https://doaj.org/article/02e91a3f73974accaf6d9c57598a718c
Autor:
Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk
Publikováno v:
Haematologica, Vol 106, Iss 10 (2020)
The diagnostic evaluation and clinical characterization of rare hereditary anemia (RHA) is to date still challenging. In particular, there is little knowledge of the broad metabolic impact of many of the molecular defects underlying RHA. In this stud
Externí odkaz:
https://doaj.org/article/6c3929b55bcc47a69b4d4c7bb71d10d1
Autor:
Caroline R.M. Wiggers, Mirna L. Baak, Edwin Sonneveld, Edward E.S. Nieuwenhuis, Marije Bartels, Menno P. Creyghton
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2866-2877.e5 (2019)
Summary: Relapse in acute myeloid leukemia (AML) may result from variable genetic origins or convergence on common biological processes. Exploiting the specificity and sensitivity of regulatory DNA, we analyze patient samples of multiple clinical out
Externí odkaz:
https://doaj.org/article/4ddac489f2b645c6b704215a8032921b
Autor:
Anita M.A.P. Govers, Caroline R.M. Wiggers, Ruben van Boxtel, Michal Mokry, Edward E.S. Nieuwenhuis, Menno P. Creyghton, Marije Bartels, Paul J. Coffer
Publikováno v:
HemaSphere, Vol 3, Iss 4 (2019)
Abstract. The clinical use of histone deacetylase inhibitors (HDACi) for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last decades. Nonetheless, their effects on normal myelopoiesis remain po
Externí odkaz:
https://doaj.org/article/36797ea773fd43cdb616f8e9d2716fc3
Autor:
Janneke G.C. Peeters, Stephin J. Vervoort, Gerdien Mijnheer, Sytze de Roock, Sebastiaan J. Vastert, Edward E.S. Nieuwenhuis, Femke van Wijk, Berent J. Prakken, Michal Mokry, Jorg van Loosdregt
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 14-17 (2016)
For many autoimmune diseases, the underlying mechanism is still unknown. In order to get more insight into the etiology of autoimmune diseases, we recently published a study were we performed epigenetic profiling and RNA sequencing on CD4+CD45RO+ T c
Externí odkaz:
https://doaj.org/article/6dbc2f4586c74de19591eab33d154407
Autor:
Janneke G.C. Peeters, Stephin J. Vervoort, Sander C. Tan, Gerdien Mijnheer, Sytze de Roock, Sebastiaan J. Vastert, Edward E.S. Nieuwenhuis, Femke van Wijk, Berent J. Prakken, Menno P. Creyghton, Paul J. Coffer, Michal Mokry, Jorg van Loosdregt
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1986-1996 (2015)
The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying autoimmune diseases due to its early onset and the possibility to analyze c
Externí odkaz:
https://doaj.org/article/c1cd1e2fa1d44680972416383a34d42e
Publikováno v:
Mucosal Immunology. 15:605-619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fe47bcf3fa9278542cf5fe71d8ed76
https://doi.org/10.1038/s41385-022-00527-6
https://doi.org/10.1038/s41385-022-00527-6
Autor:
Irena J.J. Muffels, Imre F. Schene, Holger Rehmann, Maarten P.G. Massink, Maria M. van der Wal, Corinna Bauder, Martha Labeur, Natalia G. Armando, Maarten H. Lequin, Michiel L. Houben, Jaques C. Giltay, Saskia Haitjema, Albert Huisman, Fleur Vansenne, Judith Bluvstein, John Pappas, Lala V. Shailee, Yuri A. Zarate, Michal Mokry, Gijs W. van Haaften, Edward E.S. Nieuwenhuis, Damian Refojo, Femke van Wijk, Sabine A. Fuchs, Peter M. van Hasselt
Publikováno v:
Am. J. Hum. Genet. 110, 146-160 (2023)
Am J Hum Genet
Am J Hum Genet
Neddylation has been implicated in various cellular pathways and in the pathophysiology of numerous diseases. We identified four individuals with bi-allelic variants in NAE1, which encodes the neddylation E1 enzyme. Pathogenicity was supported by dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c527b80bc5f1809a16c16e4c32929181
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67154
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67154
