Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Edward E. Morrisey"'
Autor:
Kazushige Shiraishi, Michael P. Morley, Dakota L. Jones, Gan Zhao, Aaron I. Weiner, Maria C. Basil, Edward Cantu, Laura T. Ferguson, Michele Oyster, Apoorva Babu, Yun Ying, Su Zhou, Shanru Li, Andrew E. Vaughan, Edward E. Morrisey
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Maintenance of the cellular boundary between airway and alveolar compartments during homeostasis and after injury is essential to prohibit pathological plasticity which can reduce respiratory function. Lung injury and disease can induce eith
Externí odkaz:
https://doaj.org/article/4486089a25224937b86b481d6f45d135
Autor:
Minzhe Guo, Michael P. Morley, Cheng Jiang, Yixin Wu, Guangyuan Li, Yina Du, Shuyang Zhao, Andrew Wagner, Adnan Cihan Cakar, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Geremy Clair, Joshua N. Adkins, Gloria S. Pryhuber, Ravi S. Misra, Bruce J. Aronow, Timothy L. Tickle, Nathan Salomonis, Xin Sun, Edward E. Morrisey, Jeffrey A. Whitsett, NHLBI LungMAP Consortium, Yan Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Accurate cell type identification is a key and rate-limiting step in single-cell data analysis. Single-cell references with comprehensive cell types, reproducible and functionally validated cell identities, and common nomenclatures are much
Externí odkaz:
https://doaj.org/article/3956b6ba8fe5414badfff8310d969b64
Autor:
Siqi Gao, Alan T. Tang, Min Wang, David W. Buchholz, Brian Imbiakha, Jisheng Yang, Xiaowen Chen, Peter Hewins, Patricia Mericko-Ishizuka, N. Adrian Leu, Stephanie Sterling, Avery August, Kellie A. Jurado, Edward E. Morrisey, Hector Aguilar-Carreno, Mark L. Kahn
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages endothelial cells a
Externí odkaz:
https://doaj.org/article/e5d15a44eed14d9d8481a9fdb43d3196
Autor:
Amruta Naik, Kaitlyn M. Forrest, Oindrila Paul, Yasmine Issah, Utham K. Valekunja, Soon Y. Tang, Akhilesh B. Reddy, Elizabeth J. Hennessy, Thomas G. Brooks, Fatima Chaudhry, Apoorva Babu, Michael Morley, Jarod A. Zepp, Gregory R. Grant, Garret A. FitzGerald, Amita Sehgal, G. Scott Worthen, David B. Frank, Edward E. Morrisey, Shaon Sengupta
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Optimal lung repair and regeneration are essential for recovery from viral infections, including influenza A virus (IAV). We have previously demonstrated that acute inflammation and mortality induced by IAV is under circadian control. However, it is
Externí odkaz:
https://doaj.org/article/ac4e98bc89a84f5b8ce9124207a92a10
Autor:
Fabian L. Cardenas-Diaz, Derek C. Liberti, John P. Leach, Apoorva Babu, Jonathan Barasch, Tian Shen, Maria A. Diaz-Miranda, Su Zhou, Yun Ying, Danielle A. Callaway, Michael P. Morley, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112451- (2023)
Summary: Alveolar epithelial type 2 (AT2) cells harbor the facultative progenitor capacity in the lung alveolus to drive regeneration after lung injury. Using single-cell transcriptomics, software-guided segmentation of tissue damage, and in vivo mou
Externí odkaz:
https://doaj.org/article/4e618927980d43068b36d605302b2cf2
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/137c4580968e4d02b47b51e0f226fc3b
Autor:
Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC) homeostasis; however, the understanding of how different cell populations contribute to this process is limited. Here, we utilized single-cell RNA sequencing to
Externí odkaz:
https://doaj.org/article/44b0a9ebfeff415b9c53d340fe872d68
Autor:
Sushila A. Toulmin, Chaitali Bhadiadra, Andrew J. Paris, Jeffrey H. Lin, Jeremy Katzen, Maria C. Basil, Edward E. Morrisey, G. Scott Worthen, Laurence C. Eisenlohr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host r
Externí odkaz:
https://doaj.org/article/e19c792b6eed4c79a384d45bab80f5de
Autor:
Kseniya Obraztsova, Maria C. Basil, Ryan Rue, Aravind Sivakumar, Susan M. Lin, Alexander R. Mukhitov, Andrei I. Gritsiuta, Jilly F. Evans, Meghan Kopp, Jeremy Katzen, Annette Robichaud, Elena N. Atochina-Vasserman, Shanru Li, Justine Carl, Apoorva Babu, Michael P. Morley, Edward Cantu, Michael F. Beers, David B. Frank, Edward E. Morrisey, Vera P. Krymskaya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-oper
Externí odkaz:
https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e
Autor:
Laertis Ikonomou, Michael J. Herriges, Sara L. Lewandowski, Robert Marsland, Carlos Villacorta-Martin, Ignacio S. Caballero, David B. Frank, Reeti M. Sanghrajka, Keri Dame, Maciej M. Kańduła, Julia Hicks-Berthet, Matthew L. Lawton, Constantina Christodoulou, Attila J. Fabian, Eric Kolaczyk, Xaralabos Varelas, Edward E. Morrisey, John M. Shannon, Pankaj Mehta, Darrell N. Kotton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The identity of the earliest murine in vivo lung epithelial progenitors (marked by NKX2-1 expression) is unclear. Here, the authors use single-cell RNA sequencing to define the genetic program of these lung primordial progenitors, which will improve
Externí odkaz:
https://doaj.org/article/3fb65185b9414530bfbace794788404c