Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Edward E. Graves"'
Autor:
Iris Eke, Molykutty J. Aryankalayil, Michelle A. Bylicky, Adeola Y. Makinde, Lance Liotta, Valerie Calvert, Emanuel F. Petricoin, Edward E. Graves, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The efficacy of molecular targeted therapy depends on expression and enzymatic activity of the target molecules. As radiotherapy modulates gene expression and protein phosphorylation dependent on dose and fractionation, we analyzed the long-
Externí odkaz:
https://doaj.org/article/20a423698d62445f83dc56265757f442
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Iris Eke, Michelle A. Bylicky, Veit Sandfort, Sunita Chopra, Shannon Martello, Edward E. Graves, C. Norman Coleman, Molykutty J. Aryankalayil
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 175-187 (2021)
Long non-coding RNAs (lncRNAs) have been shown to impact important biological functions such as proliferation, survival, and genomic stability. To analyze radiation-induced lncRNA expression in human tumors, we irradiated prostate cancer cells with a
Externí odkaz:
https://doaj.org/article/26b93631086d4fc78d670b89c64837ea
Autor:
Karen Levy, Suchitra Natarajan, Jinghui Wang, Stephanie Chow, Joshua T. Eggold, Phoebe E. Loo, Rakesh Manjappa, Stavros Melemenidis, Frederick M. Lartey, Emil Schüler, Lawrie Skinner, Marjan Rafat, Ryan Ko, Anna Kim, Duaa H. Al-Rawi, Rie von Eyben, Oliver Dorigo, Kerriann M. Casey, Edward E. Graves, Karl Bush, Amy S. Yu, Albert C. Koong, Peter G. Maxim, Billy W. Loo, Erinn B. Rankin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. In particular, the
Externí odkaz:
https://doaj.org/article/e19427aedbeb4ad9ab2df08481282096
Autor:
Nicolas D. Prionas, MD, PhD, Rie von Eyben, MSc, Esther Yi, BA, Sonya Aggarwal, BA, Jenny Shaffer, MD, Jose Bazan, MD, David Eastham, MD, Peter G. Maxim, PhD, Edward E. Graves, PhD, Maximilian Diehn, MD, PhD, Michael F. Gensheimer, MD, Billy W. Loo, Jr., MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 4, Iss 2, Pp 429-437 (2019)
Purpose: Quantitative changes in positron emission tomography with computed tomography imaging metrics over serial scans may be predictive biomarkers. We evaluated the relationship of pretreatment metabolic tumor growth rate (MTGR) and standardized u
Externí odkaz:
https://doaj.org/article/3b31ca1351d94d3eb46ce46824271823
Autor:
Martin Benej, Jinghai Wu, McKenzie Kreamer, Martin Kery, Sergio Corrales-Guerrero, Ioanna Papandreou, Terence M. Williams, Zihai Li, Edward E. Graves, Laura E. Selmic, Nicholas C. Denko
Publikováno v:
Cancers, Vol 13, Iss 7, p 1696 (2021)
Background: Hypoxia is found in many solid tumors and is associated with increased disease aggressiveness and resistance to therapy. Reducing oxygen demand by targeting mitochondrial oxidative metabolism is an emerging concept in translational cancer
Externí odkaz:
https://doaj.org/article/3c90478531874f859ea6b88b73ed42e0
Autor:
Todd A. Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S. Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G. Ellies, Albert C. Koong, Maximilian Diehn, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhance
Externí odkaz:
https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c
Autor:
Susan M. Hiniker, Quaovi Sodji, Andrew Quon, Paulina M. Gutkin, Natasha Arksey, Edward E. Graves, Frederick T. Chin, Peter G. Maxim, Maximilian Diehn, Billy W. Loo
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Differentiating local recurrence from post-treatment changes on PET scans following stereotactic ablative radiotherapy (SABR) or hyperfractionation for lung tumors is challenging. We performed a prospective pilot study of 3-deoxy-3-[18F]-fluorothymid
Externí odkaz:
https://doaj.org/article/e65d77a62fdd4a1eadd37a60ef8f9062
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 402-409 (2014)
Radiotherapy (RT) is a localized therapy that is highly effective in killing primary tumor cells located within the field of the radiation beam. We present evidence that irradiation of breast tumors can attract migrating breast cancer cells. Granuloc
Externí odkaz:
https://doaj.org/article/99fea5b9457f4e8aab8a89f7fec99110
Publikováno v:
Cancers, Vol 11, Iss 2, p 170 (2019)
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and
Externí odkaz:
https://doaj.org/article/abeff30624494ca097b51e25a2f5ffda