A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

Autor: Elizabeth R. Gillies, Edward E. Dy, Megan E. Fox, Jean M. J. Fréchet, Francis C. Szoka, Cameron C. Lee, Steven J. Guillaudeu

Publikováno v: Proceedings of the National Academy of Sciences. 103:16649-16654

The antitumor effect of doxorubicin (DOX) conjugated to a biodegradable dendrimer was evaluated in mice bearing C-26 colon carcinomas. An asymmetric biodegradable polyester dendrimer containing 8–10 wt % DOX was prepared. The design of the dendrime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a6d3be3a5429b7c24b0ef8c07f4c3
https://doi.org/10.1073/pnas.0607705103

PEGylated dendrimers with core functionality for biological applications

Autor: Yarah M. Haidar, Francis C. Szoka, Edward E. Dy, Megan E. Fox, Jean M. J. Frechet, Steven J. Guillaudeu

Publikováno v: Bioconjugate chemistry. 19(2)

The synthesis of a variety of core functionalized PEGylated polyester dendrimers and their in vitro and in vivo properties are described in this report. These water-soluble dendrimers have been designed to carry eight functional groups on their dendr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a3ca093221632672666377e8011e5a
https://pubmed.ncbi.nlm.nih.gov/18173227

Biological evaluation of polyester dendrimer: poly(ethylene oxide) 'bow-tie' hybrids with tunable molecular weight and architecture

Autor: Edward E. Dy, Francis C. Szoka, Jean M. J. Frechet, Elizabeth R. Gillies

Publikováno v: Molecular pharmaceutics. 2(2)

High molecular weight (MW) polymers have shown promise in terms of improving the properties and the efficacy of low MW therapeutics. However, new systems that are highly biocompatible, are biodegradable, have well-defined MW, and have multiple functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5edbab6768d41379d2fe82348856777
https://pubmed.ncbi.nlm.nih.gov/15804187

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.

Autor: Labonté ED; Ardelyx, Inc., Fremont, California., Carreras CW; Ardelyx, Inc., Fremont, California., Leadbetter MR; Ardelyx, Inc., Fremont, California., Kozuka K; Ardelyx, Inc., Fremont, California., Kohler J; Ardelyx, Inc., Fremont, California., Koo-McCoy S; Ardelyx, Inc., Fremont, California., He L; Ardelyx, Inc., Fremont, California., Dy E; Ardelyx, Inc., Fremont, California., Black D; Ardelyx, Inc., Fremont, California., Zhong Z; Ardelyx, Inc., Fremont, California., Langsetmo I; Ardelyx, Inc., Fremont, California., Spencer AG; Ardelyx, Inc., Fremont, California., Bell N; Ardelyx, Inc., Fremont, California., Deshpande D; Ardelyx, Inc., Fremont, California., Navre M; Ardelyx, Inc., Fremont, California., Lewis JG; Ardelyx, Inc., Fremont, California., Jacobs JW; Ardelyx, Inc., Fremont, California., Charmot D; Ardelyx, Inc., Fremont, California dcharmot@ardelyx.com.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2015 May; Vol. 26 (5), pp. 1138-49. Date of Electronic Publication: 2014 Nov 17.

Induction of protective immunity against malaria by priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8+-T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii.

Autor: González-Aseguinolaza G; Department of Medical & Molecular Parasitology, NYU School of Medicine. Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA., Nakaya Y, Molano A, Dy E, Esteban M, Rodríguez D, Rodríguez JR, Palese P, García-Sastre A, Nussenzweig RS

Publikováno v: Journal of virology [J Virol] 2003 Nov; Vol. 77 (21), pp. 11859-66.