Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Edward E Large"'
Autor:
Yuehui Zhao, Lijiang Long, Wen Xu, Richard F Campbell, Edward E Large, Joshua S Greene, Patrick T McGrath
Publikováno v:
eLife, Vol 7 (2018)
The standard reference Caenorhabditis elegans strain, N2, has evolved marked behavioral changes in social feeding behavior since its isolation from the wild. We show that the causal, laboratory-derived mutations in two genes, npr-1 and glb-5, confer
Externí odkaz:
https://doaj.org/article/e2419bf95fcc4a1abd409c499fa1aab3
Autor:
Edward E Large, Raghavendra Padmanabhan, Kathie L Watkins, Richard F Campbell, Wen Xu, Patrick T McGrath
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006769 (2017)
Most biological traits and common diseases have a strong but complex genetic basis, controlled by large numbers of genetic variants with small contributions to a trait or disease risk. The effect-size of most genetic variants is not absolute and is i
Externí odkaz:
https://doaj.org/article/d6b5c8bc8d9a4939a1c1a1b1fd5b9ae6
Autor:
Edward E Large, Wen Xu, Yuehui Zhao, Shannon C Brady, Lijiang Long, Rebecca A Butcher, Erik C Andersen, Patrick T McGrath
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006219 (2016)
Evolutionary life history theory seeks to explain how reproductive and survival traits are shaped by selection through allocations of an individual's resources to competing life functions. Although life-history traits evolve rapidly, little is known
Externí odkaz:
https://doaj.org/article/306f379612264d4a9d149f6e31d46b97
Autor:
Edward E. Large, Michael S. Chapman
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared. Many are neutralizing, and the predominant mechanisms have been
Externí odkaz:
https://doaj.org/article/598c3186f5d143258cddb7c1dcd0f34d
Publikováno v:
Viruses, Vol 13, Iss 7, p 1336 (2021)
Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of
Externí odkaz:
https://doaj.org/article/e4229ef27cf1491e9bbb9e131f793b53
Publikováno v:
Journal of Virology. 96
Adeno-associated virus (AAV) is a small ssDNA satellite virus of high interest (in recombinant form) as a safe and effective gene therapy vector. AAV's human cell entry receptor (AAVR) contains polycystic kidney disease (PKD) domains bound by AAV. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6c3914f1ee182fee6e289b56210f1c
https://doi.org/10.1128/jvi.01484-22
https://doi.org/10.1128/jvi.01484-22
Autor:
Dong Xu, Jason D. Gillman, Henry T. Nguyen, Thang C. La, Grover Shannon, Edward E. Large, Qijian Song, Earl Taliercio, Andrew Scaboo
Publikováno v:
Crop Science. 59:233-251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2991b81160e781e4fa733d4236197b1
https://doi.org/10.2135/cropsci2017.08.0514
https://doi.org/10.2135/cropsci2017.08.0514
Autor:
Qing Xie, Michael Chapman, Omar Davulcu, Grant M. Zane, Edward E. Large, Mark A. Silveria, Nancy L. Meyer
Publikováno v:
Bio Protoc
Adeno-associated virus (AAV) is a promising gene therapy vector and the biophysical characterization of its interactions with host proteins is a critical foundation for engineering tissue targeting and immune escape. Presented here are protocols for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c669599e322b111399e47061e1d3c9f1
https://doi.org/10.21769/bioprotoc.3513
https://doi.org/10.21769/bioprotoc.3513
Autor:
Patrick T. McGrath, Joshua S Greene, Yuehui Zhao, Lijiang Long, Edward E. Large, Wen Xu, Richard F. Campbell
Publikováno v:
eLife, Vol 7 (2018)
The standard reference Caenorhabditis elegans strain, N2, has evolved marked behavioral changes in social feeding behavior since its isolation from the wild. We show that the causal, laboratory-derived mutations in two genes, npr-1 and glb-5, confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d14e9d15c7af6043840ae44865ef7f
https://doi.org/10.7554/elife.38675
https://doi.org/10.7554/elife.38675
