Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Edward Dere"'
Autor:
Karl T. Kelsey, Matthew Rytel, Edward Dere, Rondi Butler, Melissa Eliot, Susan M. Huse, E. Andres Houseman, Devin C. Koestler, Kim Boekelheide
Publikováno v:
Environmental Health, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Exposure to the herbicide Agent Orange during the Vietnam War was widespread and is associated with numerous adverse health outcomes. A continuing concern of veterans is the possibility that exposure to the dioxin-containing herbi
Externí odkaz:
https://doaj.org/article/9710d39898574969ac92632bcf2b5eed
Autor:
Enrica Bianchi, Kim Boekelheide, Mark Sigman, Joseph M Braun, Melissa Eliot, Susan J Hall, Edward Dere, Kathleen Hwang
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216584 (2019)
Semen analysis is one of the standard diagnostic tools currently used to assess male infertility and reproductive toxicity. However, semen analysis has a limited ability to separate fertile from infertile populations. Additional methods to detect imp
Externí odkaz:
https://doaj.org/article/f5744a9d6d4846a4a89e5d3a61df56ec
Autor:
Breanna S. Vollmar, Mingjian Fei, Wei-Ching Liang, Daniel D. Bravo, Joy Wang, Lanlan Yu, Nick Corr, Gu Zhang, Erin McNamara, Shabkhaiz Masih, Elin Chee, Gawon Shin, Rachana Ohri, Douglas D. Leipold, Cong Wu, Edward Dere, Jianyong Wang, Haochu Huang, Yan Wu, Minhong Yan
Publikováno v:
Bioconjugate chemistry. 33(10)
Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such as antibodies. We cho
Autor:
Sudin Bhattacharya, Timothy R. Zacharewski, Norbert E. Kaminski, Edward Dere, Melvin E. Andersen, Navya Shilpa Josyula
Publikováno v:
Archives of Toxicology. 94:113-126
Four decades after its discovery, the aryl hydrocarbon receptor (AHR), a ligand-inducible transcription factor (TF) activated by the persistent environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), remains an enigmatic molecule with a
Autor:
Edward Dere, Melissa Eliot, E. Andres Houseman, Susan M. Huse, Matthew Rae Rytel, Devin C. Koestler, Kim Boekelheide, Karl T. Kelsey, Rondi A. Butler
Publikováno v:
Environmental Health, Vol 18, Iss 1, Pp 1-11 (2019)
Environmental Health
Environmental Health
Background Exposure to the herbicide Agent Orange during the Vietnam War was widespread and is associated with numerous adverse health outcomes. A continuing concern of veterans is the possibility that exposure to the dioxin-containing herbicide migh
Autor:
Christoph Schorl, Daniel J. Spade, Kim Boekelheide, Edward Dere, Richard N. Freiman, Susan J. Hall
Publikováno v:
Toxicological Sciences. 167:546-558
Exposure to excess retinoic acid (RA) disrupts the development of the mammalian testicular seminiferous cord. However, the molecular events surrounding RA-driven loss of cord structure have not previously been examined. To investigate the mechanisms
Autor:
Helen Booler, Chris Schuetz, Mauricio Maia, Susan Crowell, Vladimir Bantseev, Edward Dere, Phillip Lai
Publikováno v:
Toxicologic pathology. 49(3)
FHTR2163 is an antigen-binding fragment of a humanized immunoglobulin G1 monoclonal antibody directed against high-temperature requirement A serine peptidase 1 (HTRA1) that is being developed as a potential intravitreal (ITV) treatment for patients w
Autor:
Kim Boekelheide, Michelle Vanlandingham, Sherry M. Lewis, Edward Dere, Susan J. Hall, Samantha J. Madnick, Daniel J. Spade, Linnea M. Anderson, Luísa Camacho, Susan M. Huse, Elizabeth V. McDonnell-Clark
Publikováno v:
Toxicology and Applied Pharmacology. 347:1-9
Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as an endocrine disrupting compound (EDC). There is growing concern that early life exposures to EDCs, such as BPA, can adversely affect the male reproductive tract and fu
Publikováno v:
Biology of Reproduction. 99:266-268
We examined the precise localization of dimethylated histone three lysine four (H3K4me2) in mature rat sperm. Within nonintergenic-enriched regions, half of the DNA peaks associated with H3K4me2 retention fell in gene bodies and the other half in pro
Publikováno v:
Toxicological Sciences. 153:327-340
Traditional testis histopathology endpoints remain the gold standard for evaluating testicular insult and injury in a non-clinical setting, but are invasive and unfeasible for monitoring these effects clinically in humans. Assessing testicular injury