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pro vyhledávání: '"Edward D. Matayoshi"'
Autor:
Stephen W. Fesik, Sarah A. Dorwin, Diane Bartley, Karl A. Walter, Steven W. Elmore, Uri S. Ladror, Jun Chen, Jamey Mack, Sha Jin, Kunzer Aaron R, Russell A. Judge, Paul L. Richardson, Christopher L. Lynch, Philip J. Hajduk, Jean M. Severin, Chang Park, Stephen K. Tahir, Michael D. Wendt, Edward D. Matayoshi, Andrew M. Petros, Jeffrey R. Huth, Wang Xilu, Kerry M. Swift
Publikováno v:
Chemical biologydrug design. 70(1)
The molecular chaperone HSP90 has been shown to facilitate cancer cell survival by stabilizing key proteins responsible for a malignant phenotype. We report here the results of parallel fragment-based drug design approaches in the design of novel HSP