Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Edward D. Lewandowski"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 272:C2037-C2048
Measurements of oxidative metabolism in the heart from dynamic 13C nuclear magnetic resonance (NMR) spectroscopy rely on 13C turnover in the NMR-detectable glutamate pool. A kinetic model was developed for the analysis of isotope turnover to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc752cd4c43ade92dd4c0df986e2de0b
https://doi.org/10.1152/ajpcell.1997.272.6.c2037
https://doi.org/10.1152/ajpcell.1997.272.6.c2037
Publikováno v:
Current gene therapy. 12(6)
This study examines the feasibility of using the adenoviral delivery of DNA for a non-native microRNA to suppress expression of a target protein (cytosolic NADP(+)-dependent malic-enzyme 1, ME1) in whole heart in vivo, via an isolated-heart coronary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc6f9be8f0698ddbb4c1c81d35ad80
https://pubmed.ncbi.nlm.nih.gov/22974418
https://pubmed.ncbi.nlm.nih.gov/22974418
Autor:
Edward D. Lewandowski
Publikováno v:
Circulation Research. 86:487-489
Laboratory investigations into preserving viability of the ischemic myocardium or to promote recovery during reperfusion have often focused on the intermediary pathways of energy metabolism. However, in the clinical treatment of angina, the applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0cac4bb28d53a515f51647c7971e01
https://doi.org/10.1161/01.res.86.5.487
https://doi.org/10.1161/01.res.86.5.487
Publikováno v:
Circulation Research. 68:714-725
The hypothesis that substrate availability can alter contractile function in reperfused myocardium after global ischemia was investigated in this study. Isolated rabbit hearts were placed in a dual tuned (31P/13C) NMR probe with a 9.4-T magnet and pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956081c5aac3c42f7d23804dd2b8b57a
https://doi.org/10.1161/01.res.68.3.714
https://doi.org/10.1161/01.res.68.3.714
Autor:
Edward D. Lewandowski
Publikováno v:
Circulation research. 70(3)
Pre-steady-state 13C nuclear magnetic resonance (NMR) spectra can provide a nondestructive probe of metabolic events associated with the physiology of intact organs. Therefore, the relation between phosphorylation state and intermediary metabolism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81de56b6418c8ce881212e8313a6a420
https://pubmed.ncbi.nlm.nih.gov/1537093
https://pubmed.ncbi.nlm.nih.gov/1537093
Publikováno v:
The American journal of physiology. 261(2 Pt 2)
The effects of beta-oxidation on the contractile recovery and metabolic activity of postischemic (10 min) rabbit hearts were examined during reperfusion with the short-chain fatty acid butyrate. Hearts received either 13C-enriched butyrate or acetate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29818642306b301a8863db2f8010624
https://pubmed.ncbi.nlm.nih.gov/1877663
https://pubmed.ncbi.nlm.nih.gov/1877663
Publikováno v:
Circulation research. 68(2)
The effects of inosine (INO) on substrate metabolism and rigor formation in ischemic myocardium were examined in isolated rabbit hearts. Metabolite content was assessed in tissue extracts by chemical analysis and in the whole heart by 13C and 31P nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df99dc0484c892aebce2900ddec8b22e
https://pubmed.ncbi.nlm.nih.gov/1991356
https://pubmed.ncbi.nlm.nih.gov/1991356
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 253:H1215-H1223
An isolated, working, rabbit heart has been developed for use with nuclear magnetic resonance (NMR) spectroscopy. This model is functionally stable over a 4-h period and displays classic hemodynamic responses to work-load changes. Control 31P spectra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7397c3cb412377e27dcb1207d033e5b6
https://doi.org/10.1152/ajpheart.1987.253.5.h1215
https://doi.org/10.1152/ajpheart.1987.253.5.h1215
Autor:
M. D. Devous, Edward D. Lewandowski
Publikováno v:
The American journal of physiology. 253(5 Pt 2)
The effects of exogenous inosine (IN) on high-energy phosphate metabolism and function in isolated, working rabbit hearts were monitored with 31P-nuclear magnetic resonance spectroscopy. Dynamic measurements of ATP and phosphocreatine (PCr) were made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e989e2cdde6110368f2f78885214d7c5
https://pubmed.ncbi.nlm.nih.gov/3688262
https://pubmed.ncbi.nlm.nih.gov/3688262