Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Edward D. Högestätt"'
Autor:
Peter M Zygmunt, Anna Ermund, Pouya Movahed, David A Andersson, Charlotte Simonsen, Bo A G Jönsson, Anders Blomgren, Bryndis Birnir, Stuart Bevan, Alain Eschalier, Christophe Mallet, Ana Gomis, Edward D Högestätt
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81618 (2013)
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that
Externí odkaz:
https://doaj.org/article/8dc9fcd4de7e4961b0b78813742bb4f0
Autor:
David A Barrière, Christophe Mallet, Anders Blomgren, Charlotte Simonsen, Laurence Daulhac, Frédéric Libert, Eric Chapuy, Monique Etienne, Edward D Högestätt, Peter M Zygmunt, Alain Eschalier
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70690 (2013)
The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 i
Externí odkaz:
https://doaj.org/article/810f4c07d97e42ef97cc02ab50bec1e6
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 123:589-593
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95d59791de90ceac4fc4eeda62169f2
https://doi.org/10.1111/bcpt.13058
https://doi.org/10.1111/bcpt.13058
Autor:
Christophe Mallet, David A Barrière, Anna Ermund, Bo A G Jönsson, Alain Eschalier, Peter M Zygmunt, Edward D Högestätt
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12748 (2010)
Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular over-the-counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate
Externí odkaz:
https://doaj.org/article/0d3a139e7083454482747a8944cb98df
Autor:
Edward D. Högestätt, Johan L. Å. Nilsson, Anders Blomgren, Anders Blomqvist, David Engblom, Peter M. Zygmunt, Elahe Mirrasekhian, Kiseko Shionoya
The mode of action of paracetamol (acetaminophen), which is widely used for treating pain and fever, has remained obscure, but may involve several distinct mechanisms, including cyclooxygenase inhibition and transient receptor potential ankyrin 1 (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2a3d614be1dd407646ba03517cfac2
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148562
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148562
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 114:210-216
The transient receptor potential vanilloid 4 (TRPV4) is a calcium permeable ion channel expressed in airway epithelial cells. Based on studies of cell lines and animals, TRPV4 has been suggested to play a role in the regulation of ciliary beat freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7848408b8bdd222e749b79feae654b
https://doi.org/10.1111/bcpt.12135
https://doi.org/10.1111/bcpt.12135
Autor:
Urban Johanson, Mirjam Eberhardt, Milos R. Filipovic, Tatjana I. Kichko, Per Kjellbom, Peter M. Zygmunt, Lavanya Moparthi, Peter W. Reeh, Andreas Leffler, Edward D. Högestätt
Publikováno v:
Scientific Reports
Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond to either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems to be a species-dependent divergence in temperature sensation as non-mammalian TRPA1 is hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc8048835a0ccd100d5a94a098770f0
https://doi.org/10.1038/srep28763
https://doi.org/10.1038/srep28763
Autor:
Lavanya Moparthi, Peter M. Zygmunt, Urban Johanson, Edward D. Högestätt, Sabeen Survery, Per Kjellbom
Publikováno v:
The Journal of biological chemistry. 291(52)
Temperature sensors are crucial for animals to optimize living conditions. The temperature response of the ion channel transient receptor potential A1 (TRPA1) is intriguing; some orthologs have been reported to be activated by cold and others by heat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d99568edb12303a80e8c61036fc299
https://pubmed.ncbi.nlm.nih.gov/27875296
https://pubmed.ncbi.nlm.nih.gov/27875296
Autor:
Edward D. Högestätt, Peter M. Zygmunt, Morgan Andersson, Olov Sterner, Lennart Greiff, Lisa Alenmyr
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 110:264-268
Transient receptor potential vanilloid-1 (TRPV1) has been implicated as a mediator of itch in allergic rhinitis. To address this possibility, we synthesized a TRPV1 blocker (SB-705498) for nasal administration in patients with seasonal allergic rhini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f603464575c80438f1b450eb6c12ba1
https://doi.org/10.1111/j.1742-7843.2011.00803.x
https://doi.org/10.1111/j.1742-7843.2011.00803.x
Publikováno v:
Clinical Physiology and Functional Imaging. 31:435-444
Aim: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway. The primary aim of this study was to examine topical effects of various TRP ion channel agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18917dc9de898c9fd317fec7538f88fc
https://doi.org/10.1111/j.1475-097x.2011.01039.x
https://doi.org/10.1111/j.1475-097x.2011.01039.x