Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Edward D. Bonnevie"'
Autor:
Edward D. Bonnevie, Eric Dobrzynski, Dylan Steiner, Deon Hildebrand, James Monslow, Mohan Singh, Vilma Decman, David L. Krull
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Over the past decade, automation of digital image analysis has become commonplace in both research and clinical settings. Spurred by recent advances in artificial intelligence and machine learning (AI/ML), tissue sub-compartments and cellula
Externí odkaz:
https://doaj.org/article/e4d5d37e8b8a44a48b999a78c3bb3162
Autor:
Ana P. Peredo, Tonia K. Tsinman, Edward D. Bonnevie, Xi Jiang, Harvey E. Smith, Sarah E. Gullbrand, Nathaniel A. Dyment, Robert L. Mauck
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Introduction Therapeutic interventions for intervertebral disc herniation remain scarce due to the inability of endogenous annulus fibrosus (AF) cells to respond to injury and drive tissue regeneration. Unlike other orthopedic tissues, such
Externí odkaz:
https://doaj.org/article/c7dcee710b2242e1b2f35b713803a2d6
Autor:
Edward D. Bonnevie, Beth G. Ashinsky, Bassil Dekky, Susan W. Volk, Harvey E. Smith, Robert L. Mauck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cells interpret cues from and interact with fibrous microenvironments through the body based on the mechanics and organization of these environments and the phenotypic state of the cell. This in turn regulates mechanoactive pathways, such as
Externí odkaz:
https://doaj.org/article/d831d02e33214c92a636a23dfbdcf246
Autor:
Sarah E. Gullbrand, Dong Hwa Kim, Beth G. Ashinsky, Edward D. Bonnevie, Harvey E. Smith, Robert L. Mauck
Publikováno v:
JOR Spine, Vol 3, Iss 2, Pp n/a-n/a (2020)
Abstract Tissue‐engineered whole disc replacements are an emerging treatment strategy for advanced intervertebral disc degeneration. A challenge facing the translation of tissue‐engineered disc replacement to clinical use are the opposing needs o
Externí odkaz:
https://doaj.org/article/3b369effd2274c65952fd071bb91c9b7
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216702 (2019)
Hyaluronic acid injections have been a mainstay of arthritis treatment for decades. However, much controversy remains about their clinical efficacy and their potential mechanism of action. This approach to arthritis therapy is often called viscosuppl
Externí odkaz:
https://doaj.org/article/ea365f19b0404331927bc0a76ab901cd
Autor:
Grey F. Hallström, Dakota L. Jones, Ryan C. Locke, Edward D. Bonnevie, Sung Yeon Kim, Lorielle Laforest, Diana Cruz Garcia, Robert L. Mauck
Publikováno v:
Molecular Biology of the Cell.
Chondrocyte phenotype is preserved when cells are round and the actin cytoskeleton is cortical. Conversely, these cells rapidly dedifferentiate in vitro with increased mechanoactive Rho signaling, which increases cell size and causes large actin stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2cd793c5da0a08c1b5a6ab97dd269ab
https://doi.org/10.1091/mbc.e22-12-0543
https://doi.org/10.1091/mbc.e22-12-0543
Publikováno v:
Journal of Orthopaedic Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a2a20aa589e1bb65831f533f61a6ea
https://doi.org/10.1002/jor.25545
https://doi.org/10.1002/jor.25545
Autor:
Ana P. Peredo, Sarah E. Gullbrand, Chet S. Friday, Briana S. Orozco, Edward D. Bonnevie, Rachel L. Hilliard, Hannah M. Zlotnick, George R. Dodge, Daeyeon Lee, Michael W. Hast, Thomas P. Schaer, Harvey E. Smith, Robert L. Mauck
Conventional treatment for intervertebral disc herniation alleviates pain but does not repair the annulus fibrosus (AF), resulting in a high incidence of recurrent herniation and persistent disfunction. The lack of repair and the acute inflammation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0e0a218e79d063680cedc1296fe3e1
https://doi.org/10.1101/2022.10.22.513360
https://doi.org/10.1101/2022.10.22.513360
Autor:
Ana P. Peredo, Tonia K. Tsinman, Edward D. Bonnevie, Xi Jiang, Harvey E. Smith, Sarah E. Gullbrand, Nathaniel A. Dyment, Robert L. Mauck
Therapeutic interventions for intervertebral disc herniation remain scarce due to the inability of endogenous annulus fibrosus (AF) cells to respond to injury and drive tissue regeneration. Unlike other orthopaedic tissues, such as cartilage, deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890a12764703fb11a412bc0588602aea
https://doi.org/10.1101/2022.05.06.490483
https://doi.org/10.1101/2022.05.06.490483
Autor:
Edward D. Bonnevie, Dong Hwa Kim, Harvey E. Smith, Chao Wang, Robert L. Mauck, Sarah E. Gullbrand, Beth G. Ashinsky, Lin Han
Publikováno v:
Acta Biomaterialia. 111:232-241
Tissue-engineered replacement discs are an area of intense investigation for the treatment of end-stage intervertebral disc (IVD) degeneration. These living implants can integrate into the IVD space and recapitulate native motion segment function. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76451aece8d031f1e91a4de0e826c0e
https://doi.org/10.1016/j.actbio.2020.05.019
https://doi.org/10.1016/j.actbio.2020.05.019